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Screening of 17α-ethynylestradiol and non-steroidal anti-inflammatory pharmaceuticals accumulation in Mytilus edulis trossulus (Gould, 1890) collected from the Gulf of Gdańsk Cover

Screening of 17α-ethynylestradiol and non-steroidal anti-inflammatory pharmaceuticals accumulation in Mytilus edulis trossulus (Gould, 1890) collected from the Gulf of Gdańsk

Open Access
|Dec 2016

Figures & Tables

Numbers and masses of sampled individuals of Mytilus edulis trossulus

Mussel size categories (cm)Number of individualsTotal wet mass in size categories (g)Total dry mass in size categories (g)% of water
1.1 - 2 .0638.7651.35084.6
2.1 - 3.015160.4675.60090.7
3.1 - 4.0141103.5518.20092.1
4.1 - 5107.8101.02086.9
Total365

Guidelines for bioaccumulation categorization (review in Arnot et al_ 2006)

Regulatory programCriteriaCategorizationReference
Canadian Environmental Program Act (1999)BAF or BCF = 5000 l kg−1 or log Kow > 5.0BioaccumulativeGovernment of Canada 1999
United Nations Environmental Programme Stockholm Convention (2001)BioaccumulativeUNEP 2001
Washington State Department of Ecology (2004)BioaccumulativeWashington State Department of Ecology 2004
Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) is a European Union (2007)BCF > 2000 l kg-1BioaccumulativeREACH 2007
BCF > 5000 vVery bioaccumulative
US EPA (1996)BAF > 2000 l kg−1, or log Kow > 4BioaccumulativeUnited States Environmental Protection Agency 1996

Concentrations of pharmaceuticals found in Mytilus edulis trossulus (ng per wet and dry mass of sample) and obtained BAFs

Mussel size categoriesFound pharmaceuticalsConcentrationsBAF (using wet weight)BAF (using dry weight)
ng g−1 of dry weightng g−1 of wet weightl kg−1
4.1-5 cmPAR8010.53732850
FLUR21027.5171816154
EE231040.4--

Chemical structures and basic characteristics of target pharmaceuticals

CompoundChemical structureCompoundChemical structure
Ibuprofen (IBU)M = 206.28 g mol−1pKa = 4.91log Kow = 3.97Paracetamol (PAR)M = 151.16 g mol−1pKa = 9.38log Kow = 0.46
Flurbiprofen (FLUR)M = 244.26 g mol−1pKa = 4.22log Kow = 4.11Naproxen (NAP)M = 230.26 g mol−1pKa = 4.15log Kow = 3.18
Diclofenac (DIC)M = 296.13 g mol−1pKa = 4.15log Kow = 4.51Ketoprofen (KET)M = 254.28 g mol−1pKa = 4.45log Kow = 3.12
17α-Ethynylestradiol (EE2)M = 269.4 g mol−1pKa = 10.4log Kow = 3.67
DOI: https://doi.org/10.1515/ohs-2016-0050 | Journal eISSN: 1897-3191 | Journal ISSN: 1730-413X
Language: English
Page range: 605 - 614
Submitted on: Apr 11, 2016
Accepted on: Jun 9, 2016
Published on: Dec 12, 2016
Published by: University of Gdańsk
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2016 Magda Caban, Anna Szaniawska, Piotr Stepnowski, published by University of Gdańsk
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.