Bioactive properties of selected cyanobacterial compounds
| Species | Compound | Activity | Target | References |
|---|---|---|---|---|
| Dichotrix baueriana | Bauerines A-C | antiviral | HSV-2 (Herpes Simplex Virus) | Larsen et al. (1994) |
| Microcystis ichtyoblabe | Ichtyopeptin A, B | antiviral | Influenza A virus | Zainuddin et al. (2007) |
| Nostoc ellipsosporum | Cyanovirin-N | antiviral | HIV-1 (Human Immunodeficiency Virus) | Boyd et al. (1997) Dey et al. (2000) |
| Scytonema varium | Scytovirin | antiviral | HIV-1 | Bokesh et al. (2003) |
| Spirulina platensis | Calcium spirulan | antiviral | HSV-1, HIV-1, Maesles virus, Mumps virus, Influenza virus, Polio virus, Coxsackie virus | Hayashi et al. (1996) |
| Anabaena minutissima | Minutissamide A,D | cytotoxic (anticancer) | HT-29 (Human colon cancer cell line) | Kang et al. (2011) |
| Calothrix sp. | Calothrixin A | cytotoxic (anticancer) | Human T-lymphocyte cell line (Jurkat) | Chen et al. (2003) |
| Lyngbya majuscula | Homodolastatin 16 | cytotoxic (anticancer) | Oesophageal and cervical cancer cell lines | Davies-Coleman et al. (2003) |
| Lyngbya sp. | Curacin A | cytotoxic (anticancer) | MCF-7 (Breast Cancer Cells) | Verdier-Pinard et al. (1998) |
| Microcystis aeruginosa | Aeruginoguanidine 98-A, 98C | cytotoxic (anticancer) | P388 leukemia cell line | Ishida et al. (2002) |
| Moorea producens | Apratoxin H, Apratoxin A sulfoxide | cytotoxic (anticancer) | NCI-H460 (Human lung cancer cells) | Thornburg et al. (2013) |
| Nostoc commune | Comnostin B | cytotoxic (anticancer) | KB ( cervical adenocarcinoma cells) and Caco-2 (heterogeneous human epithelial colorectal adenocarcinoma cells) | Jaki et al. (2000) |
| Nostoc sp | Cryptophycin 8 | cytotoxic (anticancer) | TSU-prostate, LNCaP-prostate, H116-colon, MX-1 breast, cell lines | Liang et al. (2005) |
| Symploca sp. | Symplostatin 3 | cytotoxic (anticancer) | Human Tumor Cell Lines | Luesch et al. (2002) |
Selected identified bioactive compounds produced by cyanobacteria and microalgae and their allelopathic influence on target organisms
| Group/species | Compound | Target organism | Mode of action | Effect | References |
|---|---|---|---|---|---|
| Cyanobacteria | |||||
| Nostoc insulare | 4,4’-dihydroxybiphenyl | cyanobacteria | unknown | growth inhibition | Volk (2005) Volk and Furket (2006) |
| Nostoc linckia | cyanobacterin LU-1 (phenolic compound) | phytoplankton | unknown | growth inhibition, photosynthesis inhibition, oxygen evolution | Gromov et al. 1991 |
| Nostoc spongiaeforme | nostocine A | phytoplankton | formation of ROS | growth inhibition | Hirata et al. (2003) |
| Nostoc spp . | LMW bacteriocin | phytoplankton | unknown | cell death | Flores and Wolk (1986) |
| nostocyclamid | phytoplankton | unknown | growth inhibition | Jüttner et al. (2001) | |
| Scytonema hofmanni | cyanobacterin | microalgae | unknown | photosynthesis inhibition at PSII, cell death | Mason et al. (1982) Gleason and Paulson (1984) Abarzua et al. (1999) |
| Microalgae | |||||
| Chlorella vulgaris | chlorellin | phytoplankton | unknown | growth retardant (autoinhibition) | Pratt and Fong (1940) cited in Legrand et al. (2003) |
| Coolia monotis | cooliatoxin | phytoplankton | membrane damage | photosynthesis inhibition, lysis | Donner et al. (2000) |
| Haslea ostrearia | marennin | microalgae | unknown | growth inhibition | Pouvreau et al. (2007) |
| Karenia mikimotoi | gymnodimine | phytoplankton | membrane damage | lysis, cell death | Yasumoto et al. (1990) Uchida et al. (1995) |
| Prorocentrum lima | okadaic acid | phytoplankton | modify physiological function | growth inhibition, protein phosphatase inhibition | Sugg and Dolah (1999) |
| Prymnesium parvum | prymnesin | phytoplankton | membrane damage | lysis, cell death | Igarashi et al. (1998) Fistarol et al. (2003) |