Have a personal or library account? Click to login

Mechanisms of tumour escape from immune surveillance

Open Access
|Dec 2016

References

  1. 1. Azuma M.: Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity. Crit Rev Immunol 2010, 30, 547-557.10.1615/CritRevImmunol.v30.i6.4021175417
  2. 2. Baltz K.M., Krusch M., Bringmann A., Brossart P., Mayer F., Kloss M., Baessler T., Kumbier I., Peterfi A., Kupka S., Kroeber S., Menzel D, Radsak M.P., Rammensee H.G., Salih H.R.: Cancer immunoediting by GITR (glucocorticoid-induced TNFrelated protein) ligand in humans: NK cell/tumor cell interactions. FASEB J 2007, 21, 2442-2454.10.1096/fj.06-7724com17360848
  3. 3. Beatty G.L., Gladney W.L.: Immune escape mechanisms as a guide for cancer immunotherapy. Clin Cancer Res 2015, 21, doi: 10.1158/1078-0432.
  4. 4. Beyer M., Schultze J.L.: Regulatory T cells: major players in the tumor microenvironment. Curr Pharm Des 2009, 15, 1879-1892.10.2174/13816120978845321119519430
  5. 5. Biller B.J., Elmslie R.E., Burnett R.C., Avery A.C., Dow S.W.: Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Vet Immunol Immunopathol 2007, 116, 69-78.10.1016/j.vetimm.2006.12.00217224188
  6. 6. Biswas S.K., Lewis C.E.: NF-κB as a central regulator of macrophage function in tumors. J Leukoc Biol 2010, 88, 877-884.10.1189/jlb.031015320573802
  7. 7. Candolfi M., Curtin J.F., Yagiz K., Assi H., Wibowo M.K., Alzadeh G.E., Foulad D., Muhammad A.K.M.G., Salehi S., Keech N., Puntel M., Liu Ch., Sanderson N.R., Kroeger K.M., Dunn R., Martins G., Lowenstein P.R., Castro M.G.: B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma. Neoplasia 2011, 13, 947-960.10.1593/neo.11024320157122028620
  8. 8. Cohen A.D., Schaer D.A., Liu C., Li Y., Hirschhorn- Cymmerman D., Kim S.C.: Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation. PLoS ONE 2010, 5, e10436. doi:10.1371/journal.pone.0010436.
  9. 9. Colotta F., Allavena P., Sica A., Garlanda C., Mantovani A.: Cancer related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009, 30, 1073-1081.10.1093/carcin/bgp12719468060
  10. 10. Condamine T., Ramachandran I., Youn J., Gabrilovich D.I.: Regulation of tumor metastasis by myeloid-derived suppressor cells. Ann Rev Med 2015, 66, 97-110.10.1146/annurev-med-051013-052304432472725341012
  11. 11. Contardi E., Palmisano G.L., Tazzari P.L., Martelli A.M., Falà F., Fabbi M., Kato T., Lucarelli E., Donati D., Polito L., Bolognesi A., Ricci F., Salvi S., Gargaglione V., Mantero S., Alberghini M., Ferrara G.B., Pistillo M.P.: CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. Int J Cancer 2005, 117, 538-550.10.1002/ijc.2115515912538
  12. 12. Facciabene A., Motz G.T., Coukos G.: T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res 2012, 72, 2162-2171.10.1158/0008-5472.CAN-11-3687334284222549946
  13. 13. Galon J., Costes A., Sanchez-Cabo F., Kirilovsky A., Mlecnik B., Lagorce-Pagès C., Tosolini M., Camus M., Berger A., Wind P., Zinzindohoué F., Bruneval P., Cugnenc P.H., Trajanoski Z., Fridman W.H., Pagès F.: Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006, 313, 1960-1964.10.1126/science.112913917008531
  14. 14. Garden O.A., Pinheiro D., Cunninghamb F.: All creatures great and small: regulatory T cells in mice, humans, dogs and other domestic animal species. Int Immunopharmacol 2011, 11, 576-588.10.1016/j.intimp.2010.11.00321093606
  15. 15. Gastman B.R., Johnson D.E., Whiteside T.L., Rabinowich H.: Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events. Blood 2000, 95, 2015-2023.10.1182/blood.V95.6.2015
  16. 16. Goldberg M.V., Drake C.G.: LAG-3 in cancer immunotherapy. Curr Top Microbiol Immunol 2011, 344, 269-278.10.1007/82_2010_114469601921086108
  17. 17. Hayashi T., Horiuchi A., Sano K., Hiraoka N., Kasai M., Ichimura T., Sudo T., Tagawa Y., Nishimura R., Ishiko O., Kanai Y., Yaegashi N., Aburatani H., Shiozawa T., Konishi I.: Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy. Sci Rep 2011, 1, 180, doi: 10.1038/srep00180.
  18. 18. Huye L.E., Dotti G.: Designing T cells for cancer immunotherapy. Discov Med 2010, 47, 297-303.
  19. 19. Ichim T.E., Zhong Z., Kaushal S., Zheng X., Ren X., Hao X., Joyce J.A., Hanley H.H., Riordan N.H., Koropatnick J., Bogin V., Minev B.R., Min W., Tullis R.H.: Exosomes as a tumor immune escape mechanism: possible therapeutic implications. J Transl Med 2008, 6, 37 http://www.translationalmedicine.com/content/6/1/37.10.1186/1479-5876-6-37250447418644158
  20. 20. Jagła M., Cichocka-Jarosz E.: Regulatory lymphocytes. Alerg Astma Immun 2007, 12, 22-29.
  21. 21. Ji H.B., Liao G., Faubion W.A., Abadia-Molina A.C., Cozzo C., Laroux F.S., Caton A., Terhorst C.: Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol 2004, 172, 5823-5827.10.4049/jimmunol.172.10.582315128759
  22. 22. Jiabei H., Ying H., Mingming H., Baolan L.: Development of PD-1/PD-L1 pathway in tumor immune microenvironment and treatment for non-small cell lung cancer. Sci Rep 2015, 5, doi:10.1038/srep13110.
  23. 23. Johnsen A.K., Templeton D.J., Sy M., Harding C.V.: Deficiency of transporter for antigen presentation (TAP) in tumor cells allows evasion of immune surveillance and increases tumorigenesis. J Immunol 1999, 163, 4224-4231.10.4049/jimmunol.163.8.4224
  24. 24. Kaufman H.L., Disis M.L.: Immune system versus tumor: shifting the balance in favor of DCs and effective immunity. J Clin Invest 2004, 113, 664-667.10.1172/JCI2114835132714991063
  25. 25. Kim P., Armstrong T., Song H., Wolpoe M., Weiss V., Manning E., Huang L., Murata S., Sgouros G., Emens L., Reilly R., Jaffe E.: Antibody association with HER-2/neu-targeted vaccine enhances CD8+ T cell responses in mice through Fc-mediated activation of DCs. J Clin Invest 2008, 188, 1700-1711.10.1172/JCI34333228979718398507
  26. 26. Kim R., Emi M., Tanabe K.: Cancer immunosuppression and autoimmune disease: beyond immunosuppressive networks for tumour immunity. Immunology 2006, 119, 254-264.10.1111/j.1365-2567.2006.02430.x178235517005005
  27. 27. Kumar V., Patel S., Tcyganov E., Gabrilovich D.I.: The nature of myeloid derived suppressor cells in the tumor microenvironment. Trends Immunol 2016, 37, 208-220.10.1016/j.it.2016.01.004477539826858199
  28. 28. Lewkowicz P., Lewkowicz N., Tchórzewski H.: CD4+CD25+ T regulatory cells in pathophysiology and therapy of immunological disorders. Postępy Hig Med Dośw 2005, 59, 371-376.
  29. 29. Lopez J., Tait S.W.G.: Mitochondrial apoptosis: killing cancer using the enemy within. Br J Cancer 2015, 112, 957-962.10.1038/bjc.2015.85436690625742467
  30. 30. Luczyński W., Krawczuk-Rybak M., Stasiak-Barmuta A.: Myeloid-derived suppressor cells - the new mechanism of immunosuppression in cancer. Postępy Hig Med Dośw 2008, 21, 18-22.
  31. 31. Luke J.L., Ott P.A.: PD-1 pathway inhibitors: The next generation of immunotherapy for advanced melanoma. Oncotarget 2015, 6, 3479-3492.10.18632/oncotarget.2980441413025682878
  32. 32. Maeda H., Shiraishi A.: TGF-beta contributes to the shift toward Th-2 type responses through direct and IL-10-mediated pathways in tumor-bearing mice. J Immunol 1996, 156, 73-78.10.4049/jimmunol.156.1.73
  33. 33. Mougiakakos D.: Regulatory T cells in colorectal cancer: from biology to prognostic relevance. Cancers 2011, 3, 1708-1731.10.3390/cancers3021708375738624212779
  34. 34. Nishikawa H., Sakaguchi S.: Regulatory T cells in tumor immunity. Int J Cancer 2010, 127, 759-767.10.1002/ijc.2542920518016
  35. 35. Oleinika K., Nibbs R.J., Graham G.J., Fraser A.R.: Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clin Exp Immunol 2013, 171, 36-45.10.1111/j.1365-2249.2012.04657.x353009323199321
  36. 36. Pinheiro D., Singh Y., Grant Ch.R., Appleton R.C., Sacchini F., Walker K.L.R., Chadbourne A.H., Palmer Ch.A., Armitage- Chan E., Thompson I., Williamson L., Cunningham F., Garden O.A.: Phenotypic and functional characterization of a CD4+CD25high FOXP3high regulatory T-cell population in the dog. Immunology 2010, 132, 111-122.10.1111/j.1365-2567.2010.03346.x301508120880379
  37. 37. Poggi A., Massaro A.M., Negrini S., Contini P., Zocchi M.R.: Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors. J Immunol 2005, 174, 2653-2660.10.4049/jimmunol.174.5.265315728472
  38. 38. Poggi A., Zocchi M.R.: Mechanisms of tumor escape: role of tumor microenvironment in inducing apoptosis of cytolytic effector cells. Arch Immunol Ther Exp 2006, 54, 323-333.10.1007/s00005-006-0038-717031467
  39. 39. Ryba M., Myśliwska J.: CD4+CD25+Foxp3+ T lymphocytes: naturally occurring T regulatory lymphocytes. Pediatr Endocrinol Diabetes Metab 2010, 16, 289-294.
  40. 40. Sato E., Olson S.H., Ahn J., Bundy B., Nishikawa H., Qian F., Jungbluth A.A., Frosina D., Gnjatic S., Ambrosone C., Kepner J., Odunsi T., Ritter G., Lele S., Chen Y.T., Ohtani H., Old L.J., Odunsi K.: Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 2005, 102, 18538-18543.10.1073/pnas.0509182102131174116344461
  41. 41. Sayers T.J.: Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol Immunother 2011, 60, 1173-1180.10.1007/s00262-011-1008-421626033
  42. 42. Schreiber H., Wu T.H., Nachman J., Kast W.M.: Immunodominance and tumor escape. Semin Cancer Biol 2002, 12, 25-31.10.1006/scbi.2001.040111926408
  43. 43. Schreiber R.D., Old L.J., Smyth M.J.: Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 2011, 331, 1565-1570.10.1126/science.120348621436444
  44. 44. Shevach E.M., Stephens G.L.: The GITR-GITRL interaction: costimulation or contrasuppression of regulatory activity? Nature Rev Immunol 2006, 6, 613-618.10.1038/nri186716868552
  45. 45. Sica A., Schioppa T., Mantovani A., Allavena P.: Tumourassociated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 2006, 42, 717-727.10.1016/j.ejca.2006.01.00316520032
  46. 46. Staveley-O’Carroll K., Sotomayor E., Montgomery J., Borello I., Hwang L., Fein S., Pardoll D., Levitsky H.: Induction of antigenspecific T cell anergy: an early event in the course of tumour progression. Proc Natl Acad Sci USA 1998, 95, 1179-1183.10.1073/pnas.95.3.1178187129448305
  47. 47. Tiemessen M.M., Jagger A.L., Evans H.G., van Herwijnen M.J., John S., Taams L.S.:CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci USA 2007, 104, 19446-19451.10.1073/pnas.0706832104214830918042719
  48. 48. Upadhyay R., Hammerich L., Peng P., Brown B., Merad M., Brody J.D.: Lymphoma: immune evasion strategies. Cancers 2015, 7, 736-762.10.3390/cancers7020736449168225941795
  49. 49. Wesołowski R., Markovitz J., Carson W.E.: Myeloid derived suppressor cells-a new therapeutic target in the treatment of cancer. J Immunother Cancer 2013, 1, 10 http://www.immunotherapyofcancer.org/content/1/1/10.10.1186/2051-1426-1-10401989524829747
  50. 50. Wolchok J.D., Chan T.A.: Cancer: Antitumour immunity gets a boost. Nature 2014, 515, 496-498.10.1038/515496a659227625428495
  51. 51. Woo S.R., Turnis M.E., Goldberg M.V., Bankoti J., Selby M., Nirschl C.L., Bettini M.L., Gravano D.M., Vogel P., Liu C.L., Tangsombatvisit S., Grosso J.F., Netto G., Smeltzer M.P., Chaux A., Utz P.J., Workman C.J., Pardoll D. M., Korman A.J., Drake C. G., Vignali D.A.A.: Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 2012, 72, 917.10.1158/0008-5472.CAN-11-1620328815422186141
  52. 52. Xiao-Feng Qin F.: Dynamic behavior and function of Foxp3 regulatory T cells in tumor bearing host. Cell Mol Immunol 2009, 6, 3-13.10.1038/cmi.2009.2400254519254475
  53. 53. Yang Y.: Cancer immunotherapy: harnessing the immune system to battle cancer. J Clin Invest 2015, 125, 3335-3337.10.1172/JCI83871458831226325031
  54. 54. Yang Z.Z., Ansell S.M.: The role of Treg cells in the cancer immunological response. Am J Immunol 2009, 5, 17-28.10.3844/ajisp.2009.17.28
  55. 55. Yuan A., Hsiao Y.J., Chen H.J., Chen H.W., Ho Ch. Ch., Chen Y.Y., Liu Y.Ch., Hong T.H., Yu S.L., Chen J.J.W., Yang P.Ch.: Opposite effects of M1 and M2 macrophage subtypes on lung cancer progression. Sci Rep 2015, 5, 1-12. 10.1038/srep14273458584326399191
Language: English
Page range: 453 - 460
Submitted on: Apr 13, 2016
Accepted on: Nov 7, 2016
Published on: Dec 17, 2016
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year

© 2016 Urszula Lisiecka, Krzysztof Kostro, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.