Changes in circulating adiponectin and tumour necrosis factor-α and their relationship with insulin resistance in periparturient dairy cows

Mecitoglu, Zafer; Senturk, Sezgin; Akgul, Gulsah; Udum, Duygu; Uzabacı, Ender; Kasap, Sevim; Catik, Serkan

doi:10.1515/jvetres-2016-0024

Abstract

Introduction: The aim of the study was to investigate changes in the serum levels of adiponectin and TNF-α, as well as insulin sensitivity, and to elucidate the possible relationship among the parameters and negative energy balance during the periparturient period of dairy cows.

Material and Methods: Thirty primiparous Holstein dairy cows were selected for the study. Blood samples were collected from each cow seven days before the expected calving date, on the calving day, and 7, 14, and 21 days after calving. Blood non-esterified fatty acids (NEFA), β-hydroxybutyric acid (BHBA), glucose, insulin, adiponectin, and TNF- α levels were measured. Revised Quantitative Insulin Sensitivity Check Index (rQUICKI) was calculated using data on NEFA, insulin, and glucose concentrations.

Results: When compared to prepartum levels, serum concentration of adiponectin significantly increased on day 21 postpartum. The rQUICKI increased and NEFA levels decreased on day 7 after parturition. Insulin and glucose levels decreased on days 7, 14, and 21 postpartum when compared with prepartum levels. BHBA levels decreased on day 21 and TNF- α concentration also decreased on days 7, 14, and 21 postpartum. Adiponectin levels positively correlated with NEFA during the preparturient period. Negative correlation was detected between adiponectin and rQUICKI on calving day and on 14^th day after parturition. TNF- α concentration positively correlated with glucose levels on day 7 prepartum and on 21^st day postpartum and with rQUICKI on 21^st day postpartum. Negative correlation was detected between adiponectin level and insulin sensitivity.

Conclusion: Based on the results of the study, we concluded that adiponectin could possibly increase insulin sensitivity when blood NEFA concentrations are elevated.

References

1. Bernstein E.L., Koutkia P., Ljungquist K., Breu J., Canavan B., Grinspoon S.: Acute regulation of adiponectin by free fatty acids. Metabolism 2004, 53, 790–793.10.1016/j.metabol.2003.12.023
Search in Google Scholar
2. Bruun J.M., Lihn A.S., Verdich C., Pedersen S.B., Toubro S., Astrup A., Richelsen B.: Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 2003, 285, 527–533.10.1152/ajpendo.00110.2003
Search in Google Scholar
3. Eicher R., Liesegang A., Bouchard E., Tremblay A.: Influence of concentrate feeding frequency and intrinsic factors on diurnal variations of blood metabolites in dairy cows. Proc Am Assoc Bov Pract, Rome, 1998, 198–202.10.21423/aabppro19985730
Search in Google Scholar
4. Ferguson J.D., Galligan D.T., Thomsen N.: Principal descriptors of body condition score in Holstein cows. J Dairy Sci 1994, 77, 2695–2703.10.3168/jds.S0022-0302(94)77212-X
Search in Google Scholar
5. Fruebis J., Tsao T.S., Javorschi S., Ebbets-Reed D., Erickson M.R., Yen F.T, Bihain B.E., Lodish H.F.: Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001, 98, 2005–2010.10.1073/pnas.98.4.2005
Search in Google Scholar
6. Hayirli A.: The role of exogenous insulin in the complex of hepatic lipidosis and ketosis associated with insulin resistance phenomenon in postpartum dairy cattle. Vet Res Commun 2006, 30, 749–774.10.1007/s11259-006-3320-6
Search in Google Scholar
7. Holtenius P., Holtenius K.: A model to estimate insulin sensitivity in dairy cows. Acta Vet Scand 2007, 49, 29–31.10.1186/1751-0147-49-29
Search in Google Scholar
8. Hotamisligil G.S., Shargill N.S., Spiegelman B.M.: Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993, 259, 87–91.10.1126/science.7678183
Search in Google Scholar
9. Kahn C.R.: Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism 1978, 27, 1893–1902.10.1016/S0026-0495(78)80007-9
Search in Google Scholar
10. Komatsu T., Itoh F., Sakumoto R., Hodate K., Obara Y., Kushibiki S.: Changes in the gene expression of adiponectin and glucose transporter 12 (GLUT12) in lactating and non-lactating cows. Anim Sci J 2007, 78, 98–102.10.1111/j.1740-0929.2006.00411.x
Search in Google Scholar
11. Kushibiki S., Hodate K., Shingu H., Ueda Y., Mori Y., Itoh T., Yokomizo Y.: Effects of long-term administration of recombinant bovine tumor necrosis factor-α on glucose metabolism and growth hormone secretion in steers. Am J Vet Res 2001, 62, 794–798.10.2460/ajvr.2001.62.79411341406
Search in Google Scholar
12. Kushibiki S.: Tumor necrosis factor-α-induced inflammatory responses in cattle. Anim Sci J 2011, 82, 504–511.10.1111/j.1740-0929.2011.00931.x21794006
Search in Google Scholar
13. Lavoie F., Frisch F., Brassard P., Normand-Lauzière F., Cyr D., Gagnon R., Drouin R., Baillargeon J.P., Carpentier A.C.: Relationship between total and high molecular weight and adiponectin levels and plasma nonesterified fatty acid tolerance during enhanced intravascular triacylglycerol lipolysis in men. J Clin Endocr Metab 2009, 94, 998–1004.10.1210/jc.2008-102119066306
Search in Google Scholar
14. Lemor A., Hosseini A., Sauerwein H., Mielenz M.: Transition period-related changes in the abundance of the mRNAs of adiponectin and its receptors, of visfatin, and of fatty acid binding receptors in adipose tissue of high-yielding dairy cows. Domest Anim Endocrinol 2009, 37, 37–44.10.1016/j.domaniend.2009.01.00419345551
Search in Google Scholar
15. Maeda N., Shimomura I., Kishida K., Nishizawa H., Matsuda M., Nagaretani H., Furuyama N., Kondo H., Takahashi M., Arita Y., Komuro R., Ouchi N., Kihara S., Tochino Y., Okutomi K., Horie M., Takeda S., Aoyama T., Funahashi T., Matsuzawa Y.: Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nature Med 2002, 8, 731–737.10.1038/nm72412068289
Search in Google Scholar
16. Mc Dowell G.H., Gooden J.M., Leenanuruksa D., Jois M., English A.W.: Effects of exogenous growth hormone on milk production and nutrient uptake by muscle and mammary tissues of dairy cows in mid-lactation. Aus J Biol Sci 1987, 40, 295–306.10.1071/BI9870295
Search in Google Scholar
17. McNamara J.P.: Lipid metabolism in adipose tissue during lactation: a model of a metabolic restricted-fed system. J Nutr 1994, 124, 1383–1391.10.1093/jn/124.suppl_8.1383S8064388
Search in Google Scholar
18. Ohtani Y., Takahashi T., Sato K., Ardiyanti A., Song S.H., Sato R., Onda K., Wada Y., Obara Y., Suzuki K., Hagino A., Roh S.G., Katoh K.: Changes in circulating adiponectin and metabolic hormone concentrations during periparturient and lactation periods in Holstein dairy cows. Anim Sci J 2012, 83, 788–795.10.1111/j.1740-0929.2012.01029.x23216544
Search in Google Scholar
19. Ohtsuka H., Koiwa M., Hitsugaya A., Kudo K., Hoshi F., Itoh N., Yokota H., Okada H., Kawamura S.: Relationship between serum TNF activity and insulin resistance in dairy cows affected with naturally occurring fatty liver. J Vet Med Sci 2001, 63, 1021–1025.10.1292/jvms.63.102111642272
Search in Google Scholar
20. Perseghin G., Caumo A., Caloni M., Testolin G., Luzi L.: Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals. J Clin Endocrinol Metab 2001, 86, 4776–4781.10.1210/jcem.86.10.790211600540
Search in Google Scholar
21. Pravettoni D., Doll K., Hummel M., Cavallone E., Re M., Belloli A.G.: Insulin resistance and abomasal motility disorders in cows detected by use of abomaso-duodenal electromyography after surgical correction of left displaced abomasum. Am J Vet Res 2004, 65, 1319–1324.10.2460/ajvr.2004.65.131915524316
Search in Google Scholar
22. Radaelli T., Uvena-Celebrezze J., Minium J., Huston-Presley L., Catalano P., Hauguel-De Mouzon S.: Maternal interleukin-6: marker of fetal growth and adiposity. J Soc Gynecol Investig 2006, 13, 53–57.10.1016/j.jsgi.2005.10.003
Search in Google Scholar
23. Sakai T., Hayakawa T., Hamakawa M., Ogura K., Kubo S.: Therapeutic effects of simultaneous use of glucose and insulin in ketotic dairy cows. J Dairy Sci 1993, 76, 109–114.10.3168/jds.S0022-0302(93)77329-4
Search in Google Scholar
24. Sano H., Nakai M., Kondo T., Terashima Y.: Insulin responsiveness to glucose and tissue responsiveness to insulin in lactating, pregnant, and nonpregnant, nonlactating beef cows. J Anim Sci 1991, 69, 1122–1127.10.2527/1991.6931122x2061244
Search in Google Scholar
25. Singh S.P., Häussler S., Heinz J.F., Akter S.H., Saremi B., Muller U., Rehage J., Dänicke S., Mielenz M., Sauerwein H.: Lactation driven dynamics of adiponectin supply from different fat depots to circulation in cows. Domest Anim Endocrinol 2014, 47, 35–46.10.1016/j.domaniend.2013.12.00124462180
Search in Google Scholar
26. Singh S.P., Häussler S., Heinz J.F., Saremi B., Mielenz B., Rehage J., Dänicke S., Mielenz M., Sauerwein H.: Supplementation with conjugated linoleic acids extends the adiponectin deficit during early lactation in dairy cows. Gen Comp Endocrinol 2014, 198, 13–21.10.1016/j.ygcen.2013.12.00824384531
Search in Google Scholar
27. Staiger H., Tschritter O., Kausch C., Lammers R., Stumvoll M., Haring H.U.: Human serum adiponectin levels are not under short-term negative control by free fatty acids in vivo. Horm Metab Res 2002, 34, 601–603.10.1055/s-2002-3542312439790
Search in Google Scholar
28. Weiss R., Dufour S., Groszmann A., Petersen K., Dziura J., Taksali S.E., Shulman G., Caprio S.: Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab 2003, 88, 2014–2018.10.1210/jc.2002-02171112727947
Search in Google Scholar
29. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., Ezaki O., Akanuma Y., Gavrilova O., Vinson C., Reitman M.L., Kagechika H., Shudo K., Yoda M., Nakano Y., Tobe K., Nagai R., Kimura S., Tomita M., Froguel P., Kadowaki T.: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Med 2001, 7, 941–946.10.1038/9098411479627
Search in Google Scholar
30. Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B.B., Kadowaki T.: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Med 2002, 8, 1288–1295.10.1038/nm78812368907
Search in Google Scholar

Changes in circulating adiponectin and tumour necrosis factor-α and their relationship with insulin resistance in periparturient dairy cows

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