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Anemia and Iron Deficiency in Heart Failure — Clinical Update Cover

Anemia and Iron Deficiency in Heart Failure — Clinical Update

Open Access
|Mar 2018

References

  1. 1. Beedkar A, Parikh R, Deshmukh P. Heart Failure and the Iron Deficiency. J Assoc Physicians India. 2017;65:79-80.
  2. 2. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011-1023.10.1056/NEJMra041809
  3. 3. Cairo G, Bernuzzi F, Recalcati S. A precious metal: Iron, an essential nutrient for all cells. Genes Nutr. 2006;1:25-39.10.1007/BF02829934
  4. 4. Moos T. Brain iron homeostasis. Dan Med Bull. 2002;49;279-301.10.1023/A:1015866809087
  5. 5. Klip IT, Comin-Colet J, Voors AA, et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J. 2013;165:575-582.e310.1016/j.ahj.2013.01.017
  6. 6. Comín-Colet J, Enjuanes C, González G, et al. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status. Eur J Heart Fail. 2013;15:1164-1172.10.1093/eurjhf/hft083
  7. 7. Ponikowski P, van Veldhuisen DJ, Comin-Colet J, et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J. 2015; 36:657-668.10.1093/eurheartj/ehu385
  8. 8. Silverberg DS, Wexler D, Blum M, et al. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol. 2000;35:1737-1744.10.1016/S0735-1097(00)00613-6
  9. 9. van Veldhuisen DJ, Anker SD, Ponikowski P, et al. Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nat Rev Cardiol. 2011;8:485-493.10.1038/nrcardio.2011.7721629210
  10. 10. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006;290:G199-G203.10.1152/ajpgi.00412.200516407589
  11. 11. Jankowska EA, von Haehling S, Anker SD, Macdougall IC, Ponikowski PP. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur Heart J. 2013;34:816-829.10.1093/eurheartj/ehs224359675923100285
  12. 12. Schaefer B, Effenberger M, Zoller H. Iron metabolism in transplantation. Transpl Int. 2014;27:1109-1117.10.1111/tri.1237424964028
  13. 13. Jankowska EA, Malyszko J, Ardehali H, et al. Iron status in patients with chronic heart failure. Eur Heart J. 2013;34:827-834.10.1093/eurheartj/ehs377369780323178646
  14. 14. von Haehling S, Anker MS, Jankowska EA, Ponikowski P, Anker SD. Anemia in chronic heart failure: can we treat? What to treat? Heart Fail Rev. 2012;17:203-210.10.1007/s10741-011-9283-x21979835
  15. 15. Jankowska EA, Rozentryt P, Witkowska A, et al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur Heart J. 2010;31:1872-1880.10.1093/eurheartj/ehq15820570952
  16. 16. Brunner-La Rocca HP, Crijns HJ. Iron i.v. in heart failure: ready for implementation? Eur Heart J. 2015;36:645-647.
  17. 17. Nanas JN, Matsouka C, Karageorgopoulos D, et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol. 2006;48:2485-2489.10.1016/j.jacc.2006.08.03417174186
  18. 18. Gstrein C, Meyer M, Anabitarte P. Iron substitution in the treatment of chronic heart failure. Swiss Med Wkly. 2017;100:w14453.10.4414/smw.2017.1445328695549
  19. 19. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;18:2129-2200.10.1093/eurheartj/ehw12827206819
  20. 20. van der Meer P, Groenveld HF, Januzzi JL Jr, van Veldhuisen DJ. Erythropoietin treatment in patients with chronic heart failure: a metaanalysis. Heart. 2009;95:1309-1314.10.1136/hrt.2008.16109119168472
  21. 21. Ponikowski P, Anker SD, Szachniewicz J, et al. Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol. 2007;49:753-762.10.1016/j.jacc.2006.11.02417306703
  22. 22. Bolger AP, Bartlett FR, Penston HS, et al. Intravenous iron alone for the treatment of anemia in patients with chronic heart failure. J Am Coll Cardiol. 2006;48:1225-1227.10.1016/j.jacc.2006.07.01516979010
  23. 23. Toblli JE, Lombrana A, Duarte P, Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol. 2007;50:1657-1665.10.1016/j.jacc.2007.07.02917950147
  24. 24. Anker SD, Comin-Colet J, Filippatos G, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361:2436-2448.10.1056/NEJMoa090835519920054
  25. 25. Ponikowski P, van Veldhuisen DJ, Comin-Colet J, et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J. 2015;36:657-668.10.1093/eurheartj/ehu385435935925176939
  26. 26. Qian C, Wei B, Ding J, Wu H, Wang Y. The Efficacy and Safety of Iron Supplementation in Patients With Heart Failure and Iron Deficiency: A Systematic Review and Meta-analysis. Can J Cardiol. 2016;32:151-159.10.1016/j.cjca.2015.06.00926454467
  27. 27. Jankowska EA, Tkaczyszyn M, Suchocki T, et al. Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials. Eur J Heart Fail. 2016;18:786-795.10.1002/ejhf.47326821594
  28. 28. Miller HJ, Hu J, Valentine JK, Gable PS. Efficacy and tolerability of intravenous ferric gluconate in the treatment of iron deficiency anemia in patients without kidney disease. Arch Intern Med. 2007;167:1327-1328.10.1001/archinte.167.12.132717592108
  29. 29. McDonagh T, Macdougall IC. Iron therapy for the treatment of iron deficiency in chronic heart failure: intravenous or oral? Eur J Heart Fail. 2015;17:248-262.
  30. 30. Lewis GD, Malhotra R, Hernandez AF, et al. Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency: the IRONOUT HF Randomized Clinical Trial. JAMA. 2017;317:1958-1966.10.1001/jama.2017.5427570304428510680
  31. 31. Beck-da-Silva L, Piardi D, Soder S, et al. IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia. Int J Cardiol. 2013;168:3439-3442.10.1016/j.ijcard.2013.04.18123680589
  32. 32. Effectiveness of Intravenous Iron Treatment vs Standard Care in Patients With Heart Failure and Iron Deficiency: a Randomised, Open-label Multicentre Trial (IRONMAN) Available at: https://clinicaltrials.gov/ct2/show/NCT02642562
  33. 33. Pereira DI, Mergler BI, Faria N, et al. Caco-2 cell acquisition of dietary iron(III) invokes a nanoparticulate endocytic pathway. PLoS One. 2013;8:e81250.10.1371/journal.pone.0081250383691324278403
  34. 34. Pisani A, Riccio E, Sabbatini M, et al. Effect of oral liposomal iron versus intravenous iron for treatment of iron deficiency anaemia in CKD patients: a randomized trial. Nephrol Dial Transplant. 2015;30:645-652.10.1093/ndt/gfu35725395392
  35. 35. Latunde-Dada GO, Pereira DI, Tempest B, et al. A nanoparticulate ferritincore mimetic is well taken up by HuTu 80 duodenal cells and its absorption in mice is regulated by body iron. J Nutr. 2014;144:1896-1902.10.3945/jn.114.201715423020725342699
  36. 36. Cleland JG, Zhang J, Pellicori P, et al. Prevalence and outcomes of anemia and haematinic deficiencies in patients with chronic heart failure. JAMA Cardiol. 2016;1:539-547.10.1001/jamacardio.2016.116127439011
  37. 37. Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.10.1172/JCI200420945
DOI: https://doi.org/10.1515/jim-2017-0092 | Journal eISSN: 2501-8132 | Journal ISSN: 2501-5974
Language: English
Page range: 308 - 311
Submitted on: Nov 2, 2017
Accepted on: Nov 28, 2017
Published on: Mar 20, 2018
Published by: Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2018 András Mester, Adriana Mitre, Erzsébet Lázár, István Benedek, Johanna Kéri, Annamária Pakucs, István Benedek, published by Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
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