The Effect of the Antioxidant Drug “U-74389G” on Haemoglobin Levels Following a Hypoxemia/ Re-oxygenation Protocol in Rats

Constantinos Tsompos; Constantinos Panoulis; Konstantinos Toutouzas; George Zografos; Apostolos Papalois

doi:10.1515/jccm-2015-0017

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The Effect of the Antioxidant Drug “U-74389G” on Haemoglobin Levels Following a Hypoxemia/ Re-oxygenation Protocol in Rats

The Journal of Critical Care Medicine

Volume 1 (2015): Issue 3 (July 2015)

By: Constantinos Tsompos, Constantinos Panoulis, Konstantinos Toutouzas, George Zografos and Apostolos Papalois

Open Access

|Aug 2015

Abstract

Critically ill patients usually present with circulatory hypoxemia and this is associated with a poorer prognosis. The aim of this experimental study was to examine the effect of U-74389G with specific regard to a hypoxemia/re-oxygenation protocol, on mean blood haemoglobin (Hgb) levels in rats.

Materials and methods: Forty rats (mean weight 231.9 g) were used in the study. Hgb levels were measured at sixty minutes (groups A and C) and at 120 minutes (groups B and D) of re-oxygenation. U-74389G was administered only in groups C and D.

Results: U-74389G administration non-significantly increased the Hgb levels by 3.95+2.10% (p=0.0604). Re-oxygenation time non-significantly increased the Hgb levels by 3.39+2.12% (p=0.1285). U-74389G administration and reoxygenation time together, significantly increased the Hgb levels by 2.55%+1.25% (p=0.0423).

Conclusions: Results of this study indicate that U-74389G administration, re-oxygenation time, but mainly their interaction significantly increase the Hgb levels within the studied time limits.

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Articles in this issue

DOI: https://doi.org/10.1515/jccm-2015-0017 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809

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Language: English

Page range: 102 - 106

Submitted on: May 2, 2015

Accepted on: Jul 5, 2015

Published on: Aug 6, 2015

Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

hypoxia,

Related subjects:

Internal medicine, other,

Surgery,

Surgery, other,

Anaesthesiology,

Emergency medicine and intensive-care medicine

© 2015 Constantinos Tsompos, Constantinos Panoulis, Konstantinos Toutouzas, George Zografos, Apostolos Papalois, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 1 (2015): Issue 3 (July 2015)