Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats

Samarghandian, Saeed; Azimi-Nezhad, Mohsen; Shabestari, Mahmoud M.; Azad, Farahzad Jabbari; Farkhondeh, Tahereh; Bafandeh, Fereshteh

doi:10.1515/intox-2015-0023

Abstract

Cadmium (Cd) is an environmental toxic metal implicated in lipid abnormalities. The present study was designed to elucidate the possible association between chronic exposure to Cd concentration and alterations in plasma lipid, lipoprotein, and oxidative stress indices in rats. Sixteen male rats were assigned to 2 groups of 8 rats each (test and control). The Cd-exposed group obtained drinking water containing cadmium chloride (CdCl₂) in the concentration of 2.0 mg Cd/L in drinking water for 3 months. At the end of the experimental period, blood samples were obtained to determine the changes of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), malondialdehyde (MDA) and also serum Cd contents. The results of the present study indicated that Cd administration significantly increased the serum levels of TG, TC, LDL-C, MDA and Cd with reduction in the HDL-C and GSH levels. In conclusion, evidence is presented that chronic exposure to low Cd concentration can adversely affect the lipid and lipoprotein profile via lipid peroxidation.

References

Almasiova V, Lukacinova A, Holovska K, Cigankova V, Nistiar F. (2012). Effect of life time low dose exposure to cadmium on lipid metabolism of Wistar rats. J microb Biotech Food sci2: 293–303.
Search in Google Scholar
Alvarez SM, Gomez NN, Scardapane L, Fornes MW, Gimenez MS. (2007). Effects of chronic exposure to cadmium on prostate lipids and morphology. Biometals20: 727–741.
Search in Google Scholar
Badisa VL, Latinwo LM, Odewumi CO, Ikediobi CO, Badisa RB, Ayuk-Takem LT, Nwoga J, West J. (2007). Mechanism of DNA damage by cadmium and interplay of antioxidant enzymes and agents. Environ Toxicol22: 141–144.
Search in Google Scholar
Boisset M, Girard F, Godin J, Boudene C. (1978). Cadmium content of lung, liver, and kidney in rats exposed to cadmium oxide fumes. Int Arch Occup Environ Health41: 41–53.
Search in Google Scholar
Casalion E, Sblano C, Landriscina C. (1997). Enzyme activity alteration by cadmium administration to rats: The possibility of iron involvement. Arch Biochem Biophy346: 171–179.
Search in Google Scholar
Chen YW, Yang CY, Huang CF, Hung DZ, Leung YM. (2009). Heavy metals, islet function and diabetes development. Islets1: 169–176.
Search in Google Scholar
Egan K, Hamridge T, Kayama F. (2005) Cadmium impact assessment of different maximum limits. Cadmium: WHO Food Additive Series., pp. 35–46, Geneva.
Search in Google Scholar
Kara H, Cevik A, Konar V, Dayangac A, Yilmaz M. (2007). Protective effects of antioxidants against cadmium-induced oxidative damage in rat testes. Biol Trace Elem Res120: 205–211.
Search in Google Scholar
Lehnert G, Klavis G, Schaller KH, Haas T. (1969). Cadmium determination in urine by atomic absorption spectrometry as a screening test in industrial medicine. Brit J industr Med, 26: 156–158.
Search in Google Scholar
Murugavel P, Pari L. (2007). Diallyl tetrasulfide protects cadmium-induced alterations in lipids and plasma lipoproteins in rats. Nutr Res27: 356–361.
Search in Google Scholar
Obianime AW, Roberts II. (2009). Antioxidants, cadmium-induced toxicity, serum biochemical and the histo-logical abnormalities of the kidney and testes of the male Wistar rats. Niger. J Physiol Sci Dec24: 177–185.
Search in Google Scholar
O’brien P, Salasinski HJ. (1998). Evidence that the reactions of cadmium in the presence of metallothionein can produce hydroxyl radicals. Arch Toxicol72: 690–700.
Search in Google Scholar
Ognjanovi CB Pavlovi CSZ, Maleti CSD, Iki CRV, Tajn A, Radoji CRM, Saici CZS, Petrovi CVM. (2003). Protective influence of vitamin E. on antioxidant defense system in the blood of rats treated with cadmium. Physiol Res52: 563–570.
Search in Google Scholar
Olisekodiaka MJ, Igbeneghu CA, Onuegbu AJ, Oduru R, Lawal AO. (2012). Lipid, lipoproteins, total antioxidant status and organ changes in rats administered high doses of cadmium chloride. Med Princ Pract21: 156–159.
Search in Google Scholar
Ozturk IM, Buyukakilli B, Balli E, Cimen B, Gunes S, Erdogan S. (2009). Determination of acute and chronic effects of cadmium on the cardiovascular system of rats. In Toxicol Mech Methods19: 308–317.
Search in Google Scholar
Pari L, Murugavel P. (2007). Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. Toxicology234: 44–50.
Search in Google Scholar
Pari L, Murugavel P. (2007). Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. Toxicology234: 44–50.
Search in Google Scholar
Pathak N, Khandelwal S. (2007). Role of oxidative stress and apoptosis in cadmium induced thymic atrophy and splenomegaly in mice. Toxicol Lett169: 95–108.
Search in Google Scholar
Placer AZ, Linda LC, Johnson B. (1966). Estimation of product of lipid peroxidation (malonyldialdehyde) in biochemical systems. Anal Biochem16: 359–364.
Search in Google Scholar
Rikans LE, Yamano T. (2000). Mechanisms of cadmium mediated acute hepatotoxicity. J Biochem14: 103–110.
Search in Google Scholar
Samarghandian S, Azimi-Nezhad M, Samini F. (2014). Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. Biomed Res Int9: 208–257.
Search in Google Scholar
Samarghandian S, Azimi-Nezhad M, Afshari R, Farkhondeh T, Karimnezhad F. (2015). Effects of buprenorphine on balance of oxidant/antioxidant system in the different ages of male rat liver. J Biochem Mol Toxicol29: 249–253.
Search in Google Scholar
Samarghandian S, Azimi-Nezhad M, Samini F. (2015). Preventive effect of safranal against oxidative damage in aged male rat brain. Exp Anim64: 65–71.
Search in Google Scholar
Samarghandian S, Borji A, Afshari R, Delkhosh MB, Gholami, A. (2013). The effect of lead acetate on oxidative stress and antioxidant status in rat bronchoalveolar lavage fluid and lung tissue. Toxicol Mech Methods23: 432–436.
Search in Google Scholar
Samarghandian S, Borji A, Tabasi SH. (2013). Effects of Cichorium intybus linn on blood glucose, lipid constituents and selected oxidative stress parameters in streptozotocin-induced diabetic rats. Cardiovasc Hematol Disord Drug Targets13: 231–236.
Search in Google Scholar
Syers JK, Gochfeld M. (2000). Environmental cadmium in the food chain: sources, pathways, and risks. Proceedings of the SCOPE Workshop, pp. 13–16, Brussels, Belgium.
Search in Google Scholar
Talas ZS, Orun I, Ozdemir I, Erdogan K, Alkan A, Yilmaz I. (2008). Antioxidative role of seleni-um against the toxic effect of heavy metals (Cd+2, Cr+3) on liver of rainbow trout (Oncorhynchus mykiss Walbaum 1792). Fish Physiol Biochem34: 217–222.
Search in Google Scholar
Tandon SK, Singh S, Prasad S, Khandekar K, Dwivedi VK, Chatterjee M, Mathur N. (2003). Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat. Toxicol Lett145: 211–217.
Search in Google Scholar
Tietze F. (1969). Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal Biochem27: 502–522.
Search in Google Scholar
Toth DF, Wonger H. (2003).Clinical Chemistry Textbook, ed 3. pp. 423, Oxford University Press, Oxford.
Search in Google Scholar
Zhang W, Fievez L, Cheu E, Bureau F, Rong W. (2010). Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats. Eur J Pharmacol628: 171–178.
Search in Google Scholar
Zhou YJ, Zhang SP, Liu CW, Cai YQ. (2009). The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK (1) cells. Toxicol In Vitro23: 288–294.
Search in Google Scholar

Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats

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