Figure 1
Figure 2
Predictors of persistent disease in published series from 2000 onwards_ Only series with a multivariate analysis which used a microsurgical technique are included into the table_
| References | Number of patients | Remission percentage (%) | Predictors of persistent disease based on multivariable analysis |
|---|---|---|---|
| Minniti et al. | 92 | 55 | Cavernous sinus invasion Size |
| Attanasio et al. | 96 | 63,5 | None |
| Kreutzer et al. | 57 | 70,2 | Dural invasion |
| Bourdelot et al. | 83 | 59 | Size >15 mm |
| van Bunderen et al. | 30 | 30 | Cavernous sinus invasion |
| Present series | 81 | 72,8 | Cavernous sinus invasion |
Comparison of preoperative characteristics between patients cured after surgery and patients with persistent disease
| Biochemical control | Persistent disease | ||
|---|---|---|---|
| Females+ | 26/59 (44%) | 8/14 (57%) | P=0,39 Fisher Exact Test |
| Age mean±satandard deviation | 43,03±16,2 | 36,68±9,42 | P=0,24 Student T test |
| Cavernouse sinus invasión | 6/59 (10%) | 17/22(77%) | p<0,001 Fisher Exact Test |
| Microadenoma | 28/59 (47%) | 0/22 (0%) | p<0,001 Fisher Exact Test |
| Preoperative GH median±interqartile range | 18,35±16,2 | 8,5±6,8 | p<0,05 Mac Niemann |
| Preoperative IGF-1 median±interqartile range | 842±277 | 805±460 | P=0,37 Mac Niemann |