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Fig. 5.
Phagocytosis of HEMA particles by peritoneal mononuclear phagocytes_ Peritoneal cells isolated from non-infected mice and mice inoculated orally with M_ vogae larvae were incubated with HEMA particles and mononuclear phagocyte populations were assayed ex vivo for phagocytic activity (FA) by microscopy, which was expressed as percentage of phagocytic cells from total counted cells_ Index of phagocytic activity (IPA) was calculated as the average number of phagocytosed particles per phagocytosing cells from total particles counted_ Data are mean ±SD after counting 300 cells per sample and assayed in duplicates for each mouse (n=8)_ Significantly different values from naïve cells isolated from non-infected mice (N): *** P<0_001; ** P<0_01; * P<0_05
| Days p.i. | N | 3 | 7 | 10 | 14 | 21 | 28 | 35 |
|---|---|---|---|---|---|---|---|---|
| FA | 53.3 ± 3.2 | 82.1 ± 4.8 P<0.001; | 88.4 ± 5.9 P<0.001; | 69.3 ± 3.5 P<0.01; | 76.6 ± 2.9 P<0.001; | 65.0 ± 1.8 P<0.05 | 61.2 ± 3.1 P<0.05 | 62.7 ± 2.8 P<0.05 |
| IFA | 6.4 ± 0.9 | 10.6 ± 0.6 P<0.01; | 12.1 ± 1.1 P<0.001; | 6.8 ± 0.3 | 6.9 ± 0.4 | 7.1 ± 1.5 | 7.4 ± 0.9 P<0.05 | 6.2 ± 2.5 |