High IL-1α production was induced in the WBN/Kob-Leprfa type 2 diabetes mellitus rat model and inhibited by Syphacia muris infection

Okamoto, M.; Ito, R.; Taira, K.; Ikeda, T.

doi:10.1515/helm-2017-0050

Abstract

The novel WBN/Kob-Lepr^fa (fa/fa) congenic rat strain is considered a useful rat model of type 2 diabetes mellitus (T2DM). Accumulating findings suggest that low-grade inflammation is a causative factor in T2DM and that circulating levels of inflammatory cytokines are associated with insulin resistance. However, inflammatory cytokine profiles and their correlations with T2DM development/progression in fa/fa rats have not been studied. In this study, we found that the fa/fa rats had considerably high plasma levels of interleukin (IL)-1α. Abundant cecal IL-1α mRNA expression and cecal inflammation with infiltrating IL-1α-producing macrophages was observed in fa/fa rats. Bone marrow derived macrophages from fa/fa rats expressed high levels of IL-1α upon lipopolysaccharide stimulation. Furthermore, Syphacia muris infection, which delays the onset of T2DM, reduced both plasma and cecal IL-1α levels in fa/fa rats. These results suggest that macrophage infiltration and IL-1α secretion comprise an important part of T2DM development and that S. muris infection inhibits pro-inflammatory cytokine expression in fa/fa rats.

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High IL-1α production was induced in the WBN/Kob-Leprfa type 2 diabetes mellitus rat model and inhibited by Syphacia muris infection

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