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Micro RNAs: an arguable appraisal in medicine Cover

Micro RNAs: an arguable appraisal in medicine

Endocrine Regulations
Volume 50 (2016): Issue 2 (April 2016)
By: ,   and    
Open Access
|May 2016
References

References

  1. Abdalla MA, Haj-Ahmad Y. Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients. J Cancer 3, 19-31, 2012. http://dx.doi.org/10.7150/jca.3.19
    Open DOISearch in Google Scholar
  2. Adachi T, Nakanishi M, Otsuka Y, Nishimura K, Hirokawa G, Goto Y, Nonogi H, Iwai N. Plasma microRNA 499 as a biomarker of acute myocardial infarction. Clin Chem 56, 1183-1185, 2010. http://dx.doi.org/10.1373/clinchem.2010.144121
    Open DOISearch in Google Scholar
  3. Adams BD, Furneaux H, White BA. Th e micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor- alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 21, 1132-1147, 2007. http://dx.doi.org/10.1210/me.2007-0022
    Open DOISearch in Google Scholar
  4. Aguado-Fraile E, Ramos E, Conde E, Rodriguez M, Martin-Gomez L, Lietor A, Candela A, Ponte B, Lia-o F, Garcia- Bermejo ML. A Pilot Study Identifying a Set of microRNAs As Precise Diagnostic Biomarkers of Acute Kidney Injury. PLoS One 10, e0127175, 2015. http://dx.doi.org/10.1371/journal.pone.0127175
    Open DOISearch in Google Scholar
  5. Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, Mitchell PS, Bennett CF, Pogosova-Agadjanyan EL, Stirewalt DL, Tait JF, Tewari M. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 108, 5003-5008, 2011. http://dx.doi.org/10.1073/pnas.1019055108
    Open DOISearch in Google Scholar
  6. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H. MicroRNA-21 (miR-21) posttranscriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27, 2128-2136, 2008. http://dx.doi.org/10.1038/sj.onc.1210856
    Open DOISearch in Google Scholar
  7. Baier SR, Nguyen C, Xie F, Wood JR, Zempleni J. MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. J Nutr 144, 1495-1500, 2014. http://dx.doi.org/10.3945/jn.114.196436
    Open DOISearch in Google Scholar
  8. Basati G, Razavi AE, Pakzad I, Malayeri FA. Circulating levels of the miRNAs, miR-194, and miR-29b, as clinically useful biomarkers for colorectal cancer. Tumour Biol [Epub ahead of print], 2015.
    Open DOISearch in Google Scholar
  9. Brase JC, Johannes M, Schlomm T, Falth M, Haese A, Steuber T, Beissbarth T, Kuner R, Sultmann H. Circulating miRNAs are correlated with tumor progression in prostate cancer. Int J Cancer 128, 608-616, 2011. http://dx.doi.org/10.1002/ijc.25376
    Open DOISearch in Google Scholar
  10. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18, 997-1006, 2008. http://dx.doi.org/10.1038/cr.2008.282
    Open DOISearch in Google Scholar
  11. Cheng H, Zhang L, Cogdell DE, Zheng H, Schetter AJ, Nykter M, Harris CC, Chen K, Hamilton SR, Zhang W. Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One 6, e17745, 2011. http://dx.doi.org/10.1371/journal.pone.0017745
    Open DOISearch in Google Scholar
  12. Chim SS, Shing TK, Hung EC, Leung TY, Lau TK, Chiu RW, Lo YM. Detection and characterization of placental microRNAs in maternal plasma. Clin Chem 54, 482-490, 2008. http://dx.doi.org/10.1373/clinchem.2007.097972
    Open DOISearch in Google Scholar
  13. Corbin R, Olsson-Carter K, Slack F. Th e role of microRNAs in synaptic development and function. BMB Rep 42, 131-135, 2009. http://dx.doi.org/10.5483/BMBRep.2009.42.3.131
    Open DOISearch in Google Scholar
  14. Cottonham CL, Kaneko S, Xu L. miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. J Biol Chem 285, 35293-35302, 2010. http://dx.doi.org/10.1074/jbc.M110.160069
    Open DOISearch in Google Scholar
  15. Creighton CJ, Fountain MD, Yu Z, Nagaraja AK, Zhu H, Khan M, Olokpa E, Zariff A, Gunaratne PH, Matzuk MM, Anderson ML. Molecular Profiling Uncovers a p53-Associated Role for MicroRNA-31 in Inhibiting the Proliferation of Serous Ovarian Carcinomas and Other Cancers. Cancer Res 70, 1906−1915, 2010. http://dx.doi.org/10.1158/0008-5472.CAN-09-3875
    Open DOISearch in Google Scholar
  16. Daige CL, Wiggins JF, Priddy L, Nelligan-Davis T, Zhao J, Brown D. Systemic delivery of a miR34a mimic as a potential therapeutic for liver cancer. Mol. Cancer Th er 13, 2352-2360, 2014. http://dx.doi.org/10.1158/1535-7163.MCT-14-0209
    Open DOISearch in Google Scholar
  17. Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464, 1067-1070, 2010. http://dx.doi.org/10.1038/nature08956
    Open DOISearch in Google Scholar
  18. Deng Y, Wang CC, Choy KW, Du Q, Chen J, Wang Q, Li L, Chung TK, Tang T. Th erapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies. Genes 538, 217−227, 2014. http://dx.doi.org/10.1016/j.gene.2013.12.019
    Open DOISearch in Google Scholar
  19. Devalliere J, Chang WG, Andrejecsk JW, Abrahimi P, Cheng CJ, Jane-wit D, Saltzman WM, Pober JS. Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation. FASEB J 28, 908−922, 2014. http://dx.doi.org/10.1096/fj.13-238527
    Open DOISearch in Google Scholar
  20. DeVincenzo J, Lambkin-Williams R, Wilkinson T, Cehelsky J, Nochur S, Walsh E, Meyers R, Gollob J, Vaishnaw A. A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proc Natl Acad Sci U S A 107, 8800, 2010. http://dx.doi.org/10.1073/pnas.0912186107
    Open DOISearch in Google Scholar
  21. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494−498, 2001. http://dx.doi.org/10.1038/35078107
    Open DOISearch in Google Scholar
  22. Escrevente C, Keller S, Altevogt P, Costa J. Interaction and uptake of exosomes by ovarian cancer cells. BMC Cancer 11, 108, 2011. http://dx.doi.org/10.1186/1471-2407-11-108
    Open DOISearch in Google Scholar
  23. Etheridge A, Lee I, Hood L, Galas D, Wang K. Extracellular microRNA: a new source of biomarkers. Mutat Res 717, 85−90, 2011. http://dx.doi.org/10.1016/j.mrfmmm.2011.03.004
    Open DOISearch in Google Scholar
  24. Fang Z, Tang J, Bai Y, Lin H, You H, Jin H, Lin L, You P, Li J, Dai Z, Liang X, Su Y, Hu Q, Wang F, Zhang ZY. Plasma levels of microRNA-24, microRNA-320a, and microRNA-423-5p are potential biomarkers for colorectal carcinoma. J Exp Clin Cancer Res 34, 86, 2015. http://dx.doi.org/10.1186/s13046-015-0198-6
    Open DOISearch in Google Scholar
  25. Ferreira R, Santos T, Amar A, Gong A, Chen TC, Tahara SM, Giannotta SL, Hofman FM. Argonaute-2 promotes miR-18a entry in human brain endothelial cells. J Am Heart Assoc 3, e000968, 2014. http://dx.doi.org/10.1161/JAHA.114.000968
    Open DOISearch in Google Scholar
  26. Garber KB, Visootsak J, Warren ST. Fragile X syndrome. Eur J Hum Genet 16, 666−672, 2008. http://dx.doi.org/10.1038/ejhg.2008.61
    Open DOISearch in Google Scholar
  27. Gavrilov K, Saltzman WM. Therapeutic siRNA: principles, challenges, and strategies. Yale J Biol Med 85, 187−200, 2012.
    Search in Google Scholar
  28. Hanke M, Hoefig K, Merz H, Feller AC, Kausch I, Jocham D, Warnecke JM, Sczakiel G. A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol Oncol 28, 655-661, 2009. http://dx.doi.org/10.1016/j.urolonc.2009.01.027
    Open DOISearch in Google Scholar
  29. Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ. Th e RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A 102, 10898-10903, 2005. http://dx.doi.org/10.1073/pnas.0504834102
    Open DOISearch in Google Scholar
  30. Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA 105, 1516-1521, 2008. http://dx.doi.org/10.1073/pnas.0707493105
    Open DOISearch in Google Scholar
  31. Hatley ME, Patrick DM, Garcia MR, Richardson JA, Bassel-Duby R, van Rooij E, Olson EN. Modulation of K-Rasdependent lung tumorigenesis by MicroRNA-21. Cancer Cell 18, 282−293, 2010. http://dx.doi.org/10.1016/j.ccr.2010.08.013
    Open DOISearch in Google Scholar
  32. Hebert SS, Horre K, Nicolai L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A 105, 6415−6420, 2008. http://dx.doi.org/10.1073/pnas.0710263105
    Open DOISearch in Google Scholar
  33. Hornby RJ, Starkey Lewis P, Dear J, Goldring C, Park BK. MicroRNAs as potential circulating biomarkers of druginduced liver injury: key current and future issues for translation to humans. Expert Rev Clin Pharmacol 7, 349−362, 2014. http://dx.doi.org/10.1586/17512433.2014.904201
    Open DOISearch in Google Scholar
  34. Hrustincova A, Votavova H, Dostalova Merkerova M. Circulating MicroRNAs: Methodological Aspects in Detection of Th ese Biomarkers.Folia Biologica (Praha) 61, 203−218, 2015.
    Search in Google Scholar
  35. Hydbring P, Badalian-Very G. Clinical applications of microRNAs. F1000Research 2, 136, 2013. http://dx.doi.org/10.12688/f1000research.2-136.v1
    Open DOISearch in Google Scholar
  36. Ishizuka A, Siomi MC,Siomi H. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev 16, 2497−2508, 2002. http://dx.doi.org/10.1101/gad.1022002
    Open DOISearch in Google Scholar
  37. Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, Persson R, King BD, Kauppinen S, Levin AA, Hodges MR. Treatment of HCV infection by targeting microRNA. N Engl J Med 368, 1685-1694, 2013. http://dx.doi.org/10.1056/NEJMoa1209026
    Open DOISearch in Google Scholar
  38. Ji R, Cheng Y, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C. MicroRNA expression signature and antisensemediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ Res 100, 1579-1588, 2007. http://dx.doi.org/10.1161/CIRCRESAHA.106.141986
    Open DOISearch in Google Scholar
  39. Ji X, Takahashi R, Hiura Y, Hirokawa G, Fukushima Y, Iwai N. Plasma miR-208 as a biomarker of myocardial injury. Clin Chem 55, 1944-1949, 2009. http://dx.doi.org/10.1373/clinchem.2009.125310
    Open DOISearch in Google Scholar
  40. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ. RAS is regulated by the let-7 microRNA family. Cell 120, 635−647, 2005. http://dx.doi.org/10.1016/j.cell.2005.01.014
    Open DOISearch in Google Scholar
  41. Jose AM. Movement of regulatory RNA between animal cells. Genesis 53, 395−416, 2015. http://dx.doi.org/10.1002/dvg.22871
    Open DOISearch in Google Scholar
  42. Kanellopoulou C, Muljo SA, Kung AL, Ganesan S, Drapkin R, Jenuwein T, Livingston DM, Rajewsky K. Dicerdeficient mouse embryonic stem cells are defective in diff erentiation and centromeric silencing. Genes Dev 19, 489-501, 2005. http://dx.doi.org/10.1101/gad.1248505
    Open DOISearch in Google Scholar
  43. Karolina DS, Tavintharan S, Armugam A, Sepramaniam S, Pek SL, Wong MT, Lim SC, Sum CF, Jeyaseelan K. Circulating miRNA profiles in patients with metabolic syndrome. J Clin Endocrinol Metab 97, E2271-E2276, 2012. http://dx.doi.org/10.1210/jc.2012-1996
    Open DOISearch in Google Scholar
  44. Karube Y, Tanaka H, Osada H, Tomida S, Tatematsu Y, Yanagisawa K, Yatabe Y, Takamizawa J, Miyoshi S, Mitsudomi T, Takahashi T. Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci 96, 111-115, 2005. http://dx.doi.org/10.1111/j.1349
    Search in Google Scholar
  45. Katsuda T, Kosaka N, Ochiya T. Th e roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers. Proteomics 14, 412−425, 2014. http://dx.doi.org/10.1002/pmic.201300389
    Open DOISearch in Google Scholar
  46. Kim HS, Lee KS, Bae HJ, Eun JW, Shen Q, Park SJ, Shin WC, Yang HD, Park M, Park WS, Kang YK, Nam SW. MicroRNA-31 functions as a tumor suppressor by regulating cell cycle and epithelial-mesenchymal transition regulatory proteins in liver cancer. Oncotarget 6, 8089-8102, 2015. http://dx.doi.org/10.18632/oncotarget.3512
    Open DOISearch in Google Scholar
  47. Kiriakidou M, Nelson PT, Kouranov A, Fitziev P, Bouyioukos C, Mourelatos Z, Hatzigeorgiou A. A combined computational-experimental approach predicts human microRNA targets. Genes Dev 18, 1165−1178, 2004. http://dx.doi.org/10.1101/gad.1184704
    Open DOISearch in Google Scholar
  48. Koldehoff M, Steckel NK, Beelen DW, Elmaagacli AH. Th erapeutic application of small interfering RNA directed against bcr-abl transcripts to a patient with imatinib-resistant chronic myeloid leukaemia. Clin Exp Med 7, 47−55, 2007. http://dx.doi.org/10.1007/s10238-007-0125-z
    Open DOISearch in Google Scholar
  49. Kole AJ, Swahari V, Hammond SM, Deshmukh M. miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis. Genes Dev 25, 125−130, 2011. http://dx.doi.org/10.1101/gad.1975411
    Open DOISearch in Google Scholar
  50. Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 285, 17442−17452, 2010. http://dx.doi.org/10.1074/jbc.M110.107821
    Open DOISearch in Google Scholar
  51. Koumangoye RB, Sakwe AM, Goodwin JS, Patel T, Ochieng J. Detachment of breast tumor cells induces rapid secretion of exosomes which subsequently mediate cellular adhesion and spreading. PLoS One 6, e24234, 2011. http://dx.doi.org/10.1371/journal.pone.0024234
    Open DOISearch in Google Scholar
  52. Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res 101, 59-68, 2007. http://dx.doi.org/10.1161/CIRCRESAHA.107.153916
    Open DOISearch in Google Scholar
  53. Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, Jacks T. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A 105, 3903−3908, 2008. http://dx.doi.org/10.1073/pnas.0712321105
    Open DOISearch in Google Scholar
  54. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol 12, 735-739, 2002. http://dx.doi.org/10.1016/S0960-9822(02)00809-6
    Open DOISearch in Google Scholar
  55. Lam JKW, Chow MYT, Zhang Y, Leung SWS. siRNA Versus miRNA as Therapeutics for Gene Silencing. Mol Th er Nucleic Acids 4, e252, 2015. http://dx.doi.org/10.1038/mtna.2015.23
    Open DOISearch in Google Scholar
  56. Lee RC, Feinbaum RL, Ambros V. Th e C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854, 1993. http://dx.doi.org/10.1016/0092-8674(93)90529-Y
    Open DOISearch in Google Scholar
  57. Lee KH, Kim SH, Lee HR, Kim W, Kim DY, Shin JC, Yoo SH, Kim KT. MicroRNA-185 oscillation controls circadian amplitude of mouse Cryptochrome 1 via translational regulation. Mol Biol Cell 24, 2248-2255, 2013. http://dx.doi.org/10.1091/mbc.E12-12-0849
    Open DOISearch in Google Scholar
  58. Li Y, Fan L, Liu S, Liu W, Zhang H, Zhou T, Wu D, Yang P, Shen L, Chen J, Jin Y. Th e promotion of bone regeneration through positive regulation of angiogenic-osteogenic coupling using microRNA-26a. Biomaterials. 34, 5048-5058, 2013. http://dx.doi.org/10.1016/j.biomaterials.2013.03.052
    Open DOISearch in Google Scholar
  59. Li H, Cheng Wu C, Aramayo R, Sachs MS, Harlowa ML. Synaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA). Sci Rep 5, 14918, 2015. http://dx.doi.org/10.1038/srep14918
    Open DOISearch in Google Scholar
  60. Liang G, Zhu Y, Sun B, Shao Y, Jing A, Wang J, Xiao Z. Assessing the survival of exogenous plant microRNA in mice. Food Sci Nutr 2, 380−388, 2014. http://dx.doi.org/10.1002/fsn3.113
    Open DOISearch in Google Scholar
  61. Liu WH, Yeh SH, Lu CC, Yu SL, Chen HY, Lin CY, Chen DS, Chen PJ. MicroRNA-18a prevents estrogen receptoralpha expression, promoting proliferation of hepatocellular carcinoma cells. Gastroenterology 136, 683−693, 2009. http://dx.doi.org/10.1053/j.gastro.2008.10.029
    Open DOISearch in Google Scholar
  62. Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, Turner RJ, Jickling G, Sharp FR. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab 30, 92-101, 2010a. http://dx.doi.org/10.1038/jcbfm.2009.186
    Open DOISearch in Google Scholar
  63. Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, Kauppinen S, Dmitrovsky E. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest 120, 1298−309, 2010b. http://dx.doi.org/10.1172/JCI39566
    Open DOISearch in Google Scholar
  64. Liu M, Zhi Q, Wang W, Zhang Q, Fang T, Ma Q. Up-regulation of miR-592 correlates with tumor progression and poor prognosis in patients with colorectal cancer. Biomed Pharmacother 69, 214−220, 2015. http://dx.doi.org/10.1016/j.biopha.2014.12.001
    Open DOISearch in Google Scholar
  65. Long G, Wang F, Li H, Yin Z, Sandip C, Lou Y, Wang Y, Chen C, Wang DW. Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans. BMC Neurol 13, 178, 2013. http://dx.doi.org/10.1186/1471-2377-13-178
    Open DOISearch in Google Scholar
  66. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. MicroRNA expression profiles classify human cancers. Nature 435, 834−838, 2005. http://dx.doi.org/10.1038/nature03702
    Open DOISearch in Google Scholar
  67. Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell 14, 843−853, 2008. http://dx.doi.org/10.1016/j.devcel.2008.03.012
    Open DOISearch in Google Scholar
  68. Luo SS, Ishibashi O, Ishikawa G, Ishikawa T, Katayama A, Mishima T, Takizawa T, Shigihara T, Goto T, Izumi A, Ohkuchi A, Matsubara S, Takeshita T,Takizawa T. Human villous trophoblasts express and secrete placenta specific microRNAs into maternal circulation via exosomes. Biol Reprod 81, 717−729, 2009. http://dx.doi.org/10.1095/biolreprod.108.075481
    Open DOISearch in Google Scholar
  69. Luo H, Zou J, Dong Z, Zeng Q, Wu D, Liu L. Up-regulated miR-17 promotes cell proliferation, tumour growth and cell cycle progression by targeting the RND3 tumour suppressor gene in colorectal carcinoma. Biochem J 442, 311−321, 2012. http://dx.doi.org/10.1042/BJ20111517
    Open DOISearch in Google Scholar
  70. Ma R, Jiang T, Kang X. Circulating microRNAs in cancer: origin, function and application. J Exp Clin Cancer Res 31, 38, 2012. http://dx.doi.org/10.1186/1756-9966-31-38
    Open DOISearch in Google Scholar
  71. Mahn R, Heukamp LC, Rogenhofer S, von Ruecker A, Muller SC, Ellinger J. Circulating microRNAs (miRNA) in serum of patients with prostate cancer. Urology 77, 1265.e9−16, 2011. http://dx.doi.org/10.1016/j.urology.2011.01.020
    Open DOISearch in Google Scholar
  72. Makeyev EV, Zhang J, Carrasco MA, Maniatis T. Th e MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNAsplicing. Mol Cell 27, 435−448, 2007. http://dx.doi.org/10.1016/j.molcel.2007.07.015
    Open DOISearch in Google Scholar
  73. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O’Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 105, 10513-10518, 2008. http://dx.doi.org/10.1073/pnas.0804549105
    Open DOISearch in Google Scholar
  74. Mogilyansky E, Rigoutsos I. The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Diff er 20, 1603−1614, 2013. http://dx.doi.org/10.1038/cdd.2013.125
    Open DOISearch in Google Scholar
  75. Mulcahy LA, Pink RC, Carter DR. Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles 3, eCollection, 2014. http://dx.doi.org/10.3402/jev.v3.24641
    Open DOISearch in Google Scholar
  76. Murata K, Furu M, Yoshitomi H, Ishikawa M, Shibuya H, Hashimoto M, Imura Y, Fujii T, Ito H, Mimori T, Matsuda S. Comprehensive microRNA Analysis Identifies miR-24 and miR-125a-5p as Plasma Biomarkers for Rheumatoid Arthritis. PLoS One 8, e69118, 2013. http://dx.doi.org/10.1371/journal.pone.0069118
    Open DOISearch in Google Scholar
  77. Nagel R, Clijsters L, Agami R. The miRNA-192/194 cluster regulates the Period gene family and the circadian clock. FEBS J 276, 5447-5455, 2009. http://dx.doi.org/10.1111/j.1742-4658.2009.07229.x
    Open DOISearch in Google Scholar
  78. Nielsen LB, Wang C, Sorensen K, Bang-Berthelsen CH, Hansen L, Andersen ML, Hougaard P, Juul A, Zhang CY, Pociot F, Mortensen HB. Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression. Exp Diabetes Res 2012, 896362, 2012. http://dx.doi.org/10.1155/2012/896362
    Open DOISearch in Google Scholar
  79. Ohshima K, Inoue K, Fujiwara A, Hatakeyama K, Kanto K, Watanabe Y, Muramatsu K, Fukuda Y, Ogura S, Yamaguchi K, Mochizuki T. Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS One 5, e13247, 2010. http://dx.doi.org/10.1371/journal.pone.0013247
    Open DOISearch in Google Scholar
  80. Pang J, Xiong H, Yang H, Ou Y, Xu Y, Huang Q, Lai L, Chen S, Zhang Z, Cai Y, Zheng Y. Circulating miR-34a levels correlate with age-related hearing loss in mice and humans. Exp Gerontol 76, 58−67, 2016. http://dx.doi.org/10.1016/j.exger.2016.01.009
    Open DOISearch in Google Scholar
  81. Park NJ, Zhou H, Elashoff D, Henson BS, Kastratovic DA, Abemayor E, Wong DT. Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection. Clin Cancer Res 15, 5473-5477, 2009. http://dx.doi.org/10.1158/1078-0432.CCR-09-0736
    Open DOISearch in Google Scholar
  82. Pedersen I, David M. MicroRNAs in the immune response. Cytokine 43, 391−394, 2008. http://dx.doi.org/10.1016/j.cyto.2008.07.016
    Open DOISearch in Google Scholar
  83. Persengiev S, Kondova I, Otting N, Koeppen AH, Bontrop RE. Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebell arataxia pathogenesis. Neurobiol Aging 32, 2316. e17−27, 2011. http://dx.doi.org/10.1016/j.neurobiolaging.2010.03.014
    Open DOISearch in Google Scholar
  84. Pigati L, Yaddanapudi SC, Iyengar R, Kim DJ, Hearn SA, Danforth D, Hastings ML, Duelli DM. Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One 5, e13515, 2010. http://dx.doi.org/10.1371/journal.pone.0013515
    Open DOISearch in Google Scholar
  85. Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, Mercatanti A, Hammond S, Rainaldi G. MicroRNAs modulate the angiogenic properties of HUVECs. Blood 108, 3068-3071, 2006. http://dx.doi.org/10.1182/blood-2006-01-012369
    Open DOISearch in Google Scholar
  86. Poy MN, Spranger M, Stoffel M. microRNAs and the regulation of glucose and lipid metabolism. Diabetes Obes Metab 9, 67−73, 2007. http://dx.doi.org/10.1111/j.1463-1326.2007.00775.x
    Open DOISearch in Google Scholar
  87. Pritchard CC, Kroh E, Wood B, Arroyo JD, Dougherty KJ, Miyaji MM, Tait JF, Tewari M. Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev Res (Phila) 5, 492−497, 2012. http://dx.doi.org/10.1158/1940-6207.CAPR-11-0370
    Open DOISearch in Google Scholar
  88. Redis RS, Calin S, Yang Y, You MJ, Calin GA. Cell-to-cell miRNA transfer: from body homeostasis to therapy. Pharmacol Th er 136, 169−174, 2012. http://dx.doi.org/10.1016/j.pharmthera.2012.08.003
    Open DOISearch in Google Scholar
  89. Reid G, Kirschner MB, van Zandwijk N. Circulating microRNAs: Association with disease and potential use as biomarkers. Crit Rev Oncol Hematol 80, 193−208, 2011. http://dx.doi.org/10.1016/j.critrevonc.2010.11.004
    Open DOISearch in Google Scholar
  90. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. Th e 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901-906, 2000. http://dx.doi.org/10.1038/35002607
    Open DOISearch in Google Scholar
  91. Roese-Koerner B, Stappert L, Koch P, Brustle O, Borghese L. Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development. Curr Mol Med 13, 707−722, 2013. http://dx.doi.org/10.2174/1566524011313050003
    Open DOISearch in Google Scholar
  92. Sarkar J, Gou D, Turaka P, Viktorova E, Ramchandran R, Raj JU. MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am J Physiol Lung Cell Mol Physiol 299, L861−871, 2010. http://dx.doi.org/10.1152/ajplung.00201.2010
    Open DOISearch in Google Scholar
  93. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 100, 416−424, 2007. http://dx.doi.org/10.1161/01.RES.0000257913.42552.23
    Open DOISearch in Google Scholar
  94. Shende VR, Goldrick MM, Ramani S, Earnest DJ. Expression and Rhythmic Modulation of Circulating MicroRNAs Targeting the Clock Gene Bmal1 in Mice. PLoS One 6, e22586, 2011. http://dx.doi.org/10.1371/journal.pone.0022586
    Open DOISearch in Google Scholar
  95. Shi B, Sepp-Lorenzino L, Prisco M, Linsley P, deAngelis T, Baserga R. Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. J Biol Chem 282, 32582−32590, 2007. http://dx.doi.org/10.1074/jbc.M702806200
    Open DOISearch in Google Scholar
  96. Shi XB, Xue L, Ma AH, Tepper CG, Gandour-Edwards R, Kung HJ, deVere White RW. Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells. Oncogene 32, 4130−4138, 2013. http://dx.doi.org/10.1038/onc.2012.425
    Open DOISearch in Google Scholar
  97. Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, Greenberg ME. A brain-specific microRNA regulates dendritic spine development. Nature 439, 283-289, 2006. http://dx.doi.org/10.1038/nature04367
    Open DOISearch in Google Scholar
  98. Squadrito ML, Baer C, Burdet F, Maderna C, Gilfillan GD, Lyle R, Ibberson M, De Palma M. Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep 8, 1432−4146, 2014. http://dx.doi.org/10.1016/j.celrep.2014.07.035
    Open DOISearch in Google Scholar
  99. Su YW, Chen X, Jiang ZZ, Wang T, Wang C, Zhang Y, Wen J, Xue M, Zhu D, Zhang Y, Su YJ, Xing TY, Zhang CY, Zhang LY. A panel of serum microRNAs as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats. PLoS One 7, e37395, 2012. http://dx.doi.org/10.1371/journal.pone.0037395
    Open DOISearch in Google Scholar
  100. Sun D, Yu F, Ma Y, Zhao R, Chen X, Zhu J, Zhang CY, Chen J, Zhang J. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). J Biol Chem 288, 9508−9518, 2013. http://dx.doi.org/10.1074/jbc.M112.367763
    Open DOISearch in Google Scholar
  101. Sun X, Yang Z, Zhang Y, He J, Wang F, Su P, Han J, Song Z, Fei Y. Prognostic implications of tissue and serum levels of microRNA-128 in human prostate cancer. Int J Clin Exp Pathol 8, 8394−8401, 2015.
    Search in Google Scholar
  102. Silvestre JS, Mallat Z, Tedgui A, Levy BI. Post-ischaemic neovascularization and inflammation. Cardiovasc Res 78, 242-249. 2008. http://dx.doi.org/10.1093/cvr/cvn027.
    Open DOISearch in Google Scholar
  103. Szafranski K, Abraham KJ, Mekhail K. Non-coding RNA in neural function, disease, and aging. Front Genet 6, 87, eCollection 2015. http://dx.doi.org/10.3389/fgene.2015.00087
    Open DOISearch in Google Scholar
  104. Tang P, Xiong Q, Ge W, Zhang L. Th e role of microRNAs in osteoclasts and osteoporosis. RNA Biol 11, 1355-1363, 2014. http://dx.doi.org/10.1080/15476286.2014.996462
    Open DOISearch in Google Scholar
  105. Tang R, Yang C, Ma X, Wang Y, Luo D, Huang C, Xu Z, Liu P, Yang L. MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in gastric cancer. Oncotarget, 7, 5972-5984. 2016. http://dx.doi.org/10.18632/oncotarget.6821
    Open DOISearch in Google Scholar
  106. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev 20, 2202-2207, 2006. http://dx.doi.org/10.1101/gad.1444406
    Open DOISearch in Google Scholar
  107. Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, Snitow M, Morley M, Li D, Petrenko N, Zhou S, Lu M, Gao E, Koch WJ, Stewart KM, Morrisey EE. A microRNA-hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med 7, 279ra38, 2015. http://dx.doi.org/10.1126/scitranslmed.3010841
    Open DOISearch in Google Scholar
  108. Title AC, Denzler R, Stoffel M. Uptake and Function Studies of Maternal Milk-derived MicroRNAs. J Biol Chem 290, 23680−23691, 2015. http://dx.doi.org/10.1074/jbc.M115.676734
    Open DOISearch in Google Scholar
  109. Toiyama Y, Takahashi M, Hur K, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A. Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst 105, 849−859, 2013. http://dx.doi.org/10.1093/jnci/djt101
    Open DOISearch in Google Scholar
  110. Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res 39, 7223−7233, 2011. http://dx.doi.org/10.1093/nar/gkr254
    Open DOISearch in Google Scholar
  111. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM. MicroRNA-21 induces resistance to 5-fl uorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci U S A 107, 21098−21103, 2010. http://dx.doi.org/10.1073/pnas.1015541107
    Open DOISearch in Google Scholar
  112. van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA, Olson EN. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A 103, 18255-18260, 2006. http://dx.doi.org/10.1073/pnas.0608791103
    Open DOISearch in Google Scholar
  113. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316, 575−579, 2007. http://dx.doi.org/10.1126/science.1139089
    Open DOISearch in Google Scholar
  114. van Rooij E, Olson EN. Searching for miR-acles in cardiac fibrosis. Circ Res 104, 138−140, 2009. http://dx.doi.org/10.1161/CIRCRESAHA.108.192492
    Open DOISearch in Google Scholar
  115. Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins: Nat Cell Biol 13, 423−433, 2011. http://dx.doi.org/10.1038/ncb2210
    Open DOISearch in Google Scholar
  116. Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood LE, Galas DJ. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A 106, 4402-4407, 2009a. http://dx.doi.org/10.1073/pnas.0813371106
    Open DOISearch in Google Scholar
  117. Wang CJ, Zhou ZG, Wang L, Yang L, Zhou B, Gu J, Chen HY, Sun XF. Clinicopathological signifi cance of microRNA-31, -143 and -145 expression in colorectal cancer. Dis Markers 26, 27-34, 2009b. http://dx.doi.org/10.1155/2009/921907
    Open DOISearch in Google Scholar
  118. Wang K, Zhang S, Weber J, Baxter D, Galas DJ. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res 38, 7248-7259, 2010a. http://dx.doi.org/10.1093/nar/gkq601
    Open DOISearch in Google Scholar
  119. Wang CJ, Stratmann J, Zhou ZG, Sun XF. Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells. BMC Cancer 10, 616, 2010b. http://dx.doi.org/10.1186/1471-2407-10-616
    Open DOISearch in Google Scholar
  120. Wang B, Zhang Q. Th e expression and clinical significance of circulating microRNA-21 in serum of five solid tumors. J Cancer Res Clin Oncol 138, 1659-1666, 2012. http://dx.doi.org/10.1007/s00432-012-1244-9
    Open DOISearch in Google Scholar
  121. Wang Q, Huang Z, Ni S, Xiao X, Xu Q, Wang L, Huang D, Tan C, Scheng W, Du X. Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer. PLoS One 7, e44398, 2012a. http://dx.doi.org/10.1371/journal.pone.0044398
    Open DOISearch in Google Scholar
  122. Wang H, Peng W, Ouyang X, Li W, Dai Y. Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus. Transl Res 160, 198-206, 2012b. http://dx.doi.org/10.1016/j.trsl.2012.04.002
    Open DOISearch in Google Scholar
  123. Wang YC, Li Y, Wang XY, Zhang D, Zhang H, Wu Q, He YQ, Wang JY, Zhang L, Xia H, Yan J, Li X, Ying H. Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity. Diabetologia 56, 2275-2285, 2013. http://dx.doi.org/10.1007/s00125-013-2996-8
    Open DOISearch in Google Scholar
  124. Wang F, Long G, Zhao C, Li H, Chaugai S, Wang Y, Chen C, Wang DW. Atherosclerosis-Related Circulating miRNAs as Novel and Sensitive Predictors for Acute Myocardial Infarction. PLoS One 9, e105734, 2014. http://dx.doi.org/10.1371/journal.pone.0105734
    Open DOISearch in Google Scholar
  125. Welch C, Chen Y, Stallings RL. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 26, 5017−5022, 2007. http://dx.doi.org/10.1038/sj.onc.1210293
    Open DOISearch in Google Scholar
  126. Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene Lin-14 by Lin-4 mediates temporal pattern-formation in C.elegans. Cell 75, 855-862, 1993. http://dx.doi.org/10.1016/0092-8674(93)90530-4
    Open DOISearch in Google Scholar
  127. Witwer KW, Hirschi KD. Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist. Bioessays 36, 394−406, 2014. http://dx.doi.org/10.1002/bies.201300150
    Open DOISearch in Google Scholar
  128. Wu CW, Dong YJ, Liang QY, He XQ, Ng SS, Chan FK, Sung JJ, Yu J. MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. PLoS One 8, e57036, 2013. http://dx.doi.org/10.1371/journal.pone.0057036
    Open DOISearch in Google Scholar
  129. Wulfken LM, Moritz R, Ohlmann C, Holdenrieder S, Jung V, Becker F, Herrmann E, Walgenbach-Brunagel G, von Ruecker A, Muller SC, Ellinger J. MicroRNAs in renal cell carcinoma: diagnostic implications of serum miR-1233 levels. PLoS One 6, e25787, 2011. http://dx.doi.org/10.1371/journal.pone.0025787
    Open DOISearch in Google Scholar
  130. Xiong J, Yu D, Wei N, Fu H, Cai T, Huang Y, Wu C, Zheng X, Du Q, Lin D, Liang Z. An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples. FEBS J 277, 1684−1694, 2010. http://dx.doi.org/10.1111/j.1742-4658.2010.07594.x
    Open DOISearch in Google Scholar
  131. Xiong B, Cheng Y, Ma L, Zhang C. MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells. Int J Oncol 42, 219−228, 2013. http://dxdoi/10.3892/ijo.2012.1707.
    Open DOISearch in Google Scholar
  132. Xu RS, Wu XD, Zhang SQ, Li CF, Yang L, Li DD, Zhang BG, Zhang Y, Jin JP, Zhang B. Th e tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. Int J Oncol 42, 676−682, 2013. http://dxdoi/10.3892/ijo.2012.1746
    Open DOISearch in Google Scholar
  133. Xu L, Li M, Wang M, Yan D, Feng G, An G. The expression of microRNA-375 in plasma and tissue is matched in human colorectal cancer. BMC Cancer 14, 714, 2014. http://dx.doi.org/10.1186/1471-2407-14-714
    Open DOISearch in Google Scholar
  134. Yamada H, Itoh M, Hiratsuka I, Hashimoto S. Circulating microRNAs in autoimmune thyroid diseases. Clin Endocrinol (Oxf) 81, 276−281, 2014. http://dx.doi.org/10.1111/cen.12432
    Open DOISearch in Google Scholar
  135. Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B, Zhang Y, Xu C, Bai Y, Wang H, Chen G, Wang Z. Th e muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med 13, 486-491, 2007. http://dx.doi.org/10.1038/nm1569
    Open DOISearch in Google Scholar
  136. Yang Z, Chen H, Si H, Li X, Ding X, Sheng Q, Chen P, Zhang H. Serum miR-23a, a potential biomarker for diagnosis of pre-diabetes and type 2 diabetes. Acta Diabetol 51, 823−831, 2014. http://dx.doi.org/10.1007/s00592-014-017-8
    Search in Google Scholar
  137. Yang Y, Chang S, Zhao Z, Hou NI, He K, Wang X, Gao L, Wang L, Cai D, Guo BO, Tong D, Song T, Huang C. MicroRNA-214 suppresses the proliferation of human hepatocellular carcinoma cells by targeting E2F3. Oncol Lett 10, 3779-3784, 2015. http://dx.doi.org/10.3892/ol.2015.3745
    Open DOISearch in Google Scholar
  138. Ye W, Lv Q, Wong C-KA, Hu S, Fu C, Hua Z, Cai G, Li G, Yang BB, Zhang Y. The Effect of Central Loops in miRNA:MRE Duplexes on the Efficiency of miRNA-Mediated Gene Regulation. PLoS One 3, e1719, 2008. http://dx.doi.org/10.1371/journal.pone.0001719
    Open DOISearch in Google Scholar
  139. Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A, Willeit J, Mayr M. Plasma microRNA profi ling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ Res 107, 810-817, 2010. http://dx.doi.org/10.1161/CIRCRESAHA.110.226357
    Open DOISearch in Google Scholar
  140. Zampetaki A, Willeit P, Drozdov I, Kiechl S, Mayr M. Profiling of circulating microRNAs: from single biomarkers to re-wired networks. Cardiovasc Res 93, 555−562, 2012. http://dx.doi.org/10.1093/cvr/cvr266
    Open DOISearch in Google Scholar
  141. Zeng W, Tu Y, Zhu Y, Wang Z, Li C, Lao L, Wu G. Predictive power of circulating miRNAs in detecting colorectal cancer. Tumour Biol 36, 2559−2567, 2015. http://dx.doi.org/10.1007/s13277-014-2872-2
    Open DOISearch in Google Scholar
  142. Zhang B, Wang Q, Pan X. MicroRNA and Th eir Regulatory Roles in Animals and Plants. J Cell Physiol 210, 279-289, 2007a. http://dx.doi.org/10.1002/jcp.20869
    Open DOISearch in Google Scholar
  143. Zhang B, Pan X, Cobb GP, Anderson TA. microRNAs as oncogenes and tumor suppressors. Dev Biol 302, 1-12, 2007b. http://dx.doi.org/10.1016/j.ydbio.2006.08.028
    Open DOISearch in Google Scholar
  144. Zhang C. MicroRNAs: role in cardiovascular biology and disease. Clin Sci (Lond) 114, 699-706, 2008. http://dx.doi.org/10.1042/CS20070211
    Open DOISearch in Google Scholar
  145. Zhang Z, Li Z, Gao C, Chen P, Chen J, Liu W, Xiao S, Lu H. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest 88, 1358-1366, 2008. http://dx.doi.org/10.1038/labinvest.2008.94
    Open DOISearch in Google Scholar
  146. Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian Z, Liang X, Cai X, Yin Y, Wang C, Zhang T, Zhu D, Zhang D, Xu J, Chen Q, Ba Y, Liu J, Wang Q, Chen J, Wang J, Wang M, Zhang Q, Zhang J, Zen K, Zhang CY. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 22, 107-126, 2012. http://dx.doi.org/10.1038/cr.2011.174
    Open DOISearch in Google Scholar
  147. Zheng L, Xu CC, Chen WD, Shen WL, Ruan CC, Zhu LM, Zhu DL, Gao PJ. MicroRNA-155 regulates angiotensin II type 1 receptor expression and phenotypic differentiation in vascular adventitial fibroblasts. Biochem Biophys Res Commun 400, 483−488, 2010. http://dx.doi.org/10.1016/j.bbrc.2010.08.067
    Open DOISearch in Google Scholar
  148. Zong L, Zhu Y, Liang R, Zhao HB. Gap junction mediated miRNA intercellular transfer and gene regulation: A novel mechanism for intercellulargenetic communication. Sci Rep 6, 19884, 2016. http://dx.doi.org/10.1038/srep19884
    Open DOISearch in Google Scholar
  149. Zuckerman JE, Davis ME. Clinical experiences with systemically administered siRNA-based therapeutics in cancer. Nat Rev Drug Discov 14, 843−856, 2015. http://dx.doi.org/10.1038/nrd4685
    Open DOISearch in Google Scholar
DOI: https://doi.org/10.1515/enr-2016-0013 | Journal eISSN: 1336-0329 | Journal ISSN: 1210-0668
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Language: English
Page range: 106 - 124
Published on: May 18, 2016
Published by: Slovak Academy of Sciences, Institute of Experimental Endocrinology
In partnership with: Paradigm Publishing Services
Keywords:
biomarkers,
exosome,
therapeutics,
development,
cancer,
cardiovascular,
neural
Related subjects:
Life sciences,
Molecular biology,
Neurobiology,
Medicine,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Internal medicine,
Endocrinology, diabetology

© 2016 K. Voglova, J. Bezakova, Iveta Herichova, published by Slovak Academy of Sciences, Institute of Experimental Endocrinology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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