TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Adrian Jarzynski; Anastazja Boguszewska; Ewa Kliszczewska; Lukasz Rolniak; Anna Dworzanska; Malgorzata Polz-Dacewicz

doi:10.1515/cipms-2017-0021

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TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Current Issues in Pharmacy and Medical Sciences

Volume 30 (2017): Issue 3 (December 2017)

By: Adrian Jarzynski, Anastazja Boguszewska, Ewa Kliszczewska, Lukasz Rolniak, Anna Dworzanska and Malgorzata Polz-Dacewicz

Open Access

|Dec 2017

Abstract

TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This pilot study was performed on 48 patients. Initial studies indicate a high frequency of methylation in HPV-associated (57.1%) and EBV - associated OSCC (60%) cases, whilst the highest exists in co-infection HPV/EBV (75%). Future studies on a larger group of patients, of the mechanisms of co-infection and their role in oral squamous cell carcinoma, are necessary.

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Articles in this issue

DOI: https://doi.org/10.1515/cipms-2017-0021 | Journal eISSN: 2300-6676 | Journal ISSN: 2084-980X

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Language: English

Page range: 119 - 122

Submitted on: Jun 26, 2017

Accepted on: Jul 29, 2017

Published online: Dec 29, 2017

Published in print: Sep 26, 2017

Published by: Sciendo

In partnership with: Paradigm Publishing Services

Keywords:

TP53,

methylation,

OSCC,

EBV,

HPV

Related subjects:

Medicine,

Clinical medicine,

Pharmacology, toxicology

© 2017 Adrian Jarzynski, Anastazja Boguszewska, Ewa Kliszczewska, Lukasz Rolniak, Anna Dworzanska, Malgorzata Polz-Dacewicz, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 30 (2017): Issue 3 (December 2017)