The expression BIRC6 gene in patients with chronic lymphocytic leukemia – a preliminary study

Piotr Chomik; Paulina Gil-Kulik; Malgorzata Filas; Agnieszka Wojcieszek; Mateusz Wilinski; Jolanta Karwat; Lidia Kotula; Alicja Niedojadlo; Marcin Czop; Anna Bogucka-Kocka; Maria Cioch; Ryszard Pluta; Janusz Kocki

doi:10.1515/cipms-2015-0011

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The expression BIRC6 gene in patients with chronic lymphocytic leukemia – a preliminary study

Current Issues in Pharmacy and Medical Sciences

Volume 27 (2014): Issue 3 (September 2014)

By: Piotr Chomik, Paulina Gil-Kulik, Malgorzata Filas, Agnieszka Wojcieszek, Mateusz Wilinski, Jolanta Karwat, Lidia Kotula, Alicja Niedojadlo, Marcin Czop, Anna Bogucka-Kocka, Maria Cioch, Ryszard Pluta and Janusz Kocki

Open Access

|Mar 2015

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Abstract

The BIRC6 gene encodes the Bruce (Apollon) protein. This belongs to the III class of Inhibitors of the Apoptosis Protein (IAP) and demonstrates anti-apoptotic activity (binding, inhibiting and degrading the caspases). Moreover, the Bruce protein shows multilevel activities and additional functions. The Bruce protein is involved in the maintenance of cell viability, and it is also suggested that it plays an important role in cell proliferation and diversification. Many researchers have noticed elevated BIRC6 gene expression in cell lines of brain cancer and ovarian carcinoma, leukemia, breast cancer and even in colorectal cancer tissues. Resistance to chemotherapy-inducted apoptosis in cancers characterized by BIRC6 gene over-expression was also reported. The aim of the study was to assess the BIRC6 gene expression in peripheral blood lymphocytes of patients diagnosed with chronic lymphocytic leukemia.

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Articles in this issue

DOI: https://doi.org/10.1515/cipms-2015-0011 | Journal eISSN: 2300-6676 | Journal ISSN: 2084-980X

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Language: English

Page range: 179 - 182

Submitted on: Sep 19, 2014

Accepted on: Nov 7, 2014

Published online: Mar 3, 2015

Published in print: Sep 1, 2014

Published by: Sciendo

In partnership with: Paradigm Publishing Services

Keywords:

apoptosis,

BIRC6 gene,

Apollon,

Bruce,

CLL,

chronic lymphocytic leukemia

Related subjects:

Medicine,

Clinical medicine,

Pharmacology, toxicology

© 2015 Piotr Chomik, Paulina Gil-Kulik, Malgorzata Filas, Agnieszka Wojcieszek, Mateusz Wilinski, Jolanta Karwat, Lidia Kotula, Alicja Niedojadlo, Marcin Czop, Anna Bogucka-Kocka, Maria Cioch, Ryszard Pluta, Janusz Kocki, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 27 (2014): Issue 3 (September 2014)