Figure 1
Figure 2
Distributions of SOD1 35 A/C and SOD2 Ala9Val (C/T) polymorphisms in cases and controls and risk of vitiligo_
| Genotype/Allele | OR | 95% CI | p Value | |
|---|---|---|---|---|
| SOD1 | AA | 1 | – | – |
| AC | 0.380 | 0.072-2.005 | 0.271 | |
| A | 0.688 | 0.426-1.110 | 0.281 | |
| C | – | – | – | |
| SOD2 | CC | |||
| CT | 1 | – | – | |
| TT | 1.750 | 0.889-3.446 | 0.105 | |
| C | 2.158 | 1.044-4.462 | 0.038 This is a statistically significant p value. | |
| T | 0.792 | 0.648-0.968 | 0.022 This is a statistically significant p value. | |
The genotype and allele distribution in the patient and control groups for the SOD1 35 A/C SOD2 Ala-9Val (C/T) polymorphism_
| Genotype | Patient n % | Control n % | Total | p Value | |||
|---|---|---|---|---|---|---|---|
| SOD1 | AA | 96 | 96.05 | 97 | 97.98 | 193 | |
| CA | 5 | 4.95 | 2 | 2.02 | 7 | ||
| CC | 0 | 0.00 | 0 | 0.00 | 0 | 0.277 | |
| Total | 101 | 100.00 | 99 | 100.00 | 200 | ||
| 35 A/C | A | 197 | 97.52 | 196 | 98.98 | 393 | |
| C | 5 | 2.48 | 2 | 1.02 | 7 | 0.214 | |
| Total | 202 | 100.00 | 198 | 100.00 | 400 | ||
| SOD2 | CC | 26 | 25.70 | 35 | 35.36 | 61 | |
| CT | 37 | 36.60 | 40 | 40.40 | 77 | 0 047 | |
| TT | 38 | 37.60 | 24 | 24.24 | 62 | ||
| Total | 101 | 100.00 | 99 | 100.00 | 200 | ||
| Ala9Val (C/T) | T | 154 | 76.24 | 124 | 62.63 | 278 | |
| C | 48 | 23.76 | 74 | 37.37 | 122 | 0.460 | |
| Total | 202 | 100.00 | 198 | 100.00 | 400 | ||
Demographic and clinical parameters of vitiligo patients_ (Values are presented as mean_)
| Clinical Type | n | Gender | Age | ||||
|---|---|---|---|---|---|---|---|
| n | % | F n (%) | M n (%) | F n (%) | M n (%) | ||
| Focal | 46 | 45.55 | 25 | 24.76 | 22 | 21.78 | 35.62; F: 32.16; M: 39.39 |
| Acrofacial | 25 | 24.75 | 13 | 12.87 | 11 | 10.89 | 32.15; F: 31.26; M: 33.42 |
| Generalized | 21 | 20.79 | 13 | 12.87 | 8 | 7.92 | 38.78; F: 41.34; M: 34.62 |
| Segmental | 4 | 3.96 | 2 | 1.98 | 2 | 1.98 | 27.35; F: 27.50; M: 27.20 |
| Universal | 3 | 2.97 | 3 | 2.97 | – | – | 37.56 |
| Mixed | 2 | 1.98 | 2 | 1.98 | – | – | 36.15 |
| Total | 101 | 100.00 | 58 | 57.43 | 43 | 43.57 | |