Polymorphism of the ADRB2 rs1042713 gene is not associated with spontaneous preterm birth: Analyses in a Slovenian sample and meta analysis

A Peterlin; A Maver; Z Jan; L Lovrecic; N Tul; B Peterlin

doi:10.1515/bjmg-2017-0032

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Polymorphism of the ADRB2 rs1042713 gene is not associated with spontaneous preterm birth: Analyses in a Slovenian sample and meta analysis

Balkan Journal of Medical Genetics

Volume 20 (2017): Issue 2 (December 2017)

By: A Peterlin, A Maver, Z Jan, L Lovrecic, N Tul and B Peterlin

Open Access

|Dec 2017

Figures & Tables

Flowchart of study selection process in the meta analysis.

Forest plots for the association between the ADRB2 rs1042713 polymorphism and SPTB risk in recessive and dominant genetic models.

Effects of the ADRB2 rs1042713 A allele on the ADRB2 receptor.

Association of ADRB2 rs1042713 with SPTB under different genetic models_

Genetic Model			W_SPTBvs.W_C
		OR (95% CI)	p Value	χ²
Dominant	GA+GG vs. AA	1.03 (0.52-2.04)	0.92	0.01
Recessive	AA+GA vs. GG	0.98 (0.57-1.70)	0.92	0.01
Codominant	AA+GG vs. GA	0.99 (0.59-1.68)	0.92	0.01

Characteristics of 98 mothers with SPTB and 135 controls_

Parameters	SPTB	Controls	p Value
Mean maternal age (years)	30.20 ± 4.59	30.10 ± 3.92	0.28
Smoking during pregnancy % (n)	8.3 (8)	2.9 (4)	0.15
Previous SPTB % (n)	12.4 (12)	4.3 (6)	0.08
In vitro fertilization % (n)	4.1 (4)	1.4 (2)	0.31
Urogenital infections % (n)	7.2 (7)	4.3 (6)	0.35
High blood pressure % (n)	7.2 (7)	4.3 (6)	0.35
Stressful events during pregnancy % (n)	3.1 (3)	4.3 (6)	0.50

Characteristics of studies included in the meta analysis_

Refs.	Year	Country	Population	PPROM Excluded	SPTB Cases Criteria	Case Sample Size	Control Criteria	Control Group Size
this study	2017	Slovenia	Caucasian	no	GA <37	98	GA >37	135
[30]	2013	Korea	Asian	no	GA <37	166	GA >37	289
[31]	2004	Hungary	Caucasian	no	GA <37	32	GA >37	127
[33]	2002	Turkey	Caucasian	yes	GA <37	80	GA >37	76
[32]	2002	USA	Hispanic	no	GA <37	28	GA >37	251

Genotype and allelic distribution of the ADRB2 rs1042713 polymorphism of the 98 SPTB patients and 135 controls_

Parameters	Genotype Frequencies n (%)					Allele Frequencies (n) %
	AA	GA	GG	p Value	χ²	A	G	p Value	χ²
SPTB cases	17 (17.3)	48 (49.0)	33 (33.7)	0.99	0.01	65 (42.0)	81 (42.0)	1.0	0
Controls	24 (18.0)	66 (49.0)	45 (33.0)			90 (58.0)	111 (58.0)

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DOI: https://doi.org/10.1515/bjmg-2017-0032 | Journal eISSN: 2199-5761

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Language: English

Page range: 35 - 41

Published on: Dec 29, 2017

Published by: Macedonian Academy of Sciences and Arts

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

β-2-Adrenergic receptor (ADRB2) gene,

Case-control association study,

Meta analysis,

Risk factor,

Spontaneous preterm birth (SPTB)

Related subjects:

Medicine,

Basic medical science,

Basic medical science, other

© 2017 A Peterlin, A Maver, Z Jan, L Lovrecic, N Tul, B Peterlin, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 20 (2017): Issue 2 (December 2017)

Polymorphism of the ADRB2 rs1042713 gene is not associated with spontaneous preterm birth: Analyses in a Slovenian sample and meta analysis

Figures & Tables

Figure 1

Figure 2

Figure 3

Association of ADRB2 rs1042713 with SPTB under different genetic models_

Characteristics of 98 mothers with SPTB and 135 controls_

Characteristics of studies included in the meta analysis_

Genotype and allelic distribution of the ADRB2 rs1042713 polymorphism of the 98 SPTB patients and 135 controls_

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