Table 1
Allele and genotype frequencies of the 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR mutations.
| Mutations | Alleles | Cases n (%) | Controls n (%) | OR (95% CI)aa | p Value |
|---|---|---|---|---|---|
| 1691 (G>A) FVL | wild type G/G heterozygous G/A homozygous A/A | 88 (79.30) 20 (18.00) 3 (2.70) | 199 (96.14) 8 (3.86) 0 (0.0) | 6.0 (2.62-14.4) | 0.0001 |
| allele G allele A | 196 (89.50) 23 (10.50) | 406 (98.06) 8 (1.94) | 5.6 (2.4-12.7) | 0.0001 | |
| 20210 (G>A) PT | wild type G/G heterozygous G/A homozygous A/A | 108 (97.30) 3 (2.70) 0 (0.00) | 207 (100.00) 0 (0.00) 0 (0.00) | 13.5 (0.6-263.9) | 0.087 |
| allele G allele A | 219 (98.64) 3 (1.36) | 414 (100.00) 0 (0.00) | 13.5 (0.6-263.9) | 0.087 | |
| 677 (C>T) MTHFR | wild type C/C heterozygous C/T homozygous T/T | 43 (38.74) 47 (42.34) 21 (18.92) | 91 (43.96) 92 (44.44) 24 (11.60) | 1.24 (0.77-1.98) | 0.368 |
| allele C allele T | 133 (66.16) 68 (33.84) | 274 (70.26) 116 (29.74) | 0.82 (0.57-1.19) | 0.309 |
FVL: factor V Leiden; PT: prothrombin; MTHFR: methylene tetrahydrofolate reductase; OR: odds ratio; 95% CI: 95% confidence interval.
Table 2
Allele and genotype frequencies of factor 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR mutations according to gender.
| Mutations | Alleles | Patients | Controls | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Men n (%) | Women n (%) | χ2 (df = 1)aa | p Value | Men n (%) | Women n (%) | χ2 (df = 1)aa | p Value | ||
| 1691 (G>A) FVL | wild type G/G heterozygous G/A homozygous A/A | 38 (73.08) 13 (25.00) 1 (1.92) | 46 (77.96) 11 (18.64) 2 (3.40) | 0.359 | 0.549 | 97 (95.10) 5 (4.90) 0 (0.00) | 102 (97.14) 3 (2.86) 0 (0.00) | 0.582 | 0.445 |
| allele G allele A | 89 (86.40) 14 (13.60) | 103 (88.80) 13 (12.20) | 0.287 | 0.592 | 199 (97.54) 5 (2.45) | 226 (98.26) 4 (1.74) | 0.771 | 0.387 | |
| 20210 (G>A) PT | wild type G/G heterozygous G/A homozygous A/A | 51 (98.07) 1 (1.93) 0 (0.00) | 57 (96.32) 2 (3.38) 0 (0.00) | 0.226 | 0.634 | 102 (100.00) 0 (0.00) 0 (0.00) | 105 (100.00) 0 (0.00) 0 (0.00) | – | – |
| allele G allele A | 103 (99.03) 1 (0.97) | 116 (98.30) 2(1.70) | 0.223 | 0.636 | 204 (100.00) 0 (0.00) | 210 (100.00) 0 (0.00) | – | – | |
| 677 (C>T) MTHFR | wild type C/C heterozygous C/T homozygous T/T | 18 (34.61) 25 (48.08) 9 (17.31) | 25 (42.37) 22 (37.39) 12 (20.34) | 0.701 | 0.402 | 42 (41.18) 49 (48.04) 11 (10.78) | 49 (46.67) 43 (41.90) 12 (11.43) | 0.873 | 0.350 |
| allele C allele T | 61 (64.21) 34 (34.79) | 72 (67.92) 34 (32.08) | 0.165 | 0.680 | 133 (68.91) 60 (31.09) | 141 (71.94) 55 (28.06) | 0.428 | 0.512 | |
FVL: factor V Leiden; PT: prothrombin; MTHFR: methylene tetrahydrofolate reductase.
Table 3
The Frequencies of combined genotypes of 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR.
| Combined Genotypes | Patients n (%) | Controls n (%) |
|---|---|---|
| 1691 (G>A) FVL (GG) and 20210 (G>A) PT (GG) 1691 (G>A) FVL (GA) and 20210 (G>A) PT (GA) | 85 (98.84) 1 (1.16) | 199 (100.00) 0 (0.00) |
| 1691 (G>A) FVL (GG) and 677 (C>T) MTHFR (CC) 1691 (G>A) FVL (GA) and 677 (C>T) MTHFR (CT) 1691 (G>A) FVL (GA) and 677 (C>T) MTHFR (TT) | 34 (72.34) 7 (14.90) 3 (6.39) | 90 (92.78) 6 (6.19) 1 (1.03) |
| 1691 (G>A) FVL (AA) and 677 (C>T) MTHFR (CT) 1691 (G>A) FVL (AA) and 677 (C>T) MTHFR (TT) | 2 (4.25) 1 (2.12) | 0 (0.00) 0 (0.00) |
| 20210 (G>A) PT (GG) and 677 (C>T) MTHFR (CC) 20210 (G>A) PT (GA) and 677 (C>T) MTHFR (CT) 20210 (G>A) PT (GA) and 677 (C>T) MTHFR (TT) | 43 (97.72) 1 (2.28) 0 (0.00) | 91 (100.00) 0 (0.00) 0 (0.00) |
FVL: factor V Leiden; PT: prothrombin; MTHFR: methylene tetrahydrofolate reductase.