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Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study Cover

Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study

Open Access
|Aug 2016

Figures & Tables

The level of 8-OHdG values in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL. The levels of 8-OHdG in all drug-treated groups at concentrations of 0.01 and 0.1 μg/mL were higher than control group. The asterisks (*) indicate significant differences (p <0.05) from the control group. The hash (#) indicates significant difference from all other groups.
The level of 8-OHdG values in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL. The levels of 8-OHdG in all drug-treated groups at concentrations of 0.01 and 0.1 μg/mL were higher than control group. The asterisks (*) indicate significant differences (p <0.05) from the control group. The hash (#) indicates significant difference from all other groups.
The average of SCEs/cell in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL in cultured blood cells. Increases were detected among the groups. However, it did not reach significant levels (control vs. VCR group: p >0.05; control vs. VBL group: p >0.05, and control vs. VRL group: p >0.05).
The average of SCEs/cell in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL in cultured blood cells. Increases were detected among the groups. However, it did not reach significant levels (control vs. VCR group: p >0.05; control vs. VBL group: p >0.05, and control vs. VRL group: p >0.05).
The mitotic index in cultured cells treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL. The value of the mitotic index was significantly higher (p <0.05) in lymphocytes treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL.
The mitotic index in cultured cells treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL. The value of the mitotic index was significantly higher (p <0.05) in lymphocytes treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL.
Language: English
Page range: 13 - 20
Published on: Aug 2, 2016
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2016 NM Mhaidat, KH Alzoubi, OF Khabour, KZ Alawneh, LA Raffee, ES Alsatari, EI Hussein, KE Bani-Hani, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.