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Embryo quality predictive models based on cumulus cells gene expression Cover

Embryo quality predictive models based on cumulus cells gene expression

Balkan Journal of Medical Genetics
Volume 19 (2016): Issue 1 (June 2016)
By: R Devjak,  T Burnik Papler,  I Verdenik,  K Fon Tacer and  E Vrtačnik Bokal  
Open Access
|Aug 2016

Figures & Tables

A decision tree model diagram with AMHR2 and LIF. The model first separates CC samples upon AMHR2 expression (high or low) and then upon LIF expression (high or low). The blue color represents leaves with predominantly CC of low quality embryos and red color represents leaves with predominantly CC of high quality embryos. A combination of high AMHR2 and low LIF CC expression leads to an 82.6% possibility of developing a low quality embryo, and combination of low AMHR2 and low LIF CC expression leads to 74.6% possibility of developing high quality embryos.
A decision tree model diagram with AMHR2 and LIF. The model first separates CC samples upon AMHR2 expression (high or low) and then upon LIF expression (high or low). The blue color represents leaves with predominantly CC of low quality embryos and red color represents leaves with predominantly CC of high quality embryos. A combination of high AMHR2 and low LIF CC expression leads to an 82.6% possibility of developing a low quality embryo, and combination of low AMHR2 and low LIF CC expression leads to 74.6% possibility of developing high quality embryos.

The Mann-Whitney U test results for all analyzed genes between high quality and low quality embryos (Mann-Whitney U test column); furthermore, data were split into AMHR2 high CC expression and low CC expression and analyzed using the Mann-Whitney U test (AMHR2 high group and AMHR2 low group columns)_

GeneMann-Whitney U (significance)
a

Significance expressed as a p value.

AMHR2 High Group (significance)
a

Significance expressed as a p value.

AMHR2 Low Group (significance)
a

Significance expressed as a p value.

AMHR20.03––
FSHR0.440.520.09
LIF0.110.030.59
SERPINE20.740.720.37
0.72VEGFC0.720.340.75

Binary logistic model for embryo outcome where age, body mass index and patient distribution were tested between high quality and low quality embryo groups_ None of the tested variables were shown to be significant in our data_

ParametersSignificance
a

Significance in the model expressed as a p value.

Exp(B)95% CI for Exp(B)
LowerUpper
Age0.261.100.931.28
Body mass index0.820.980.791.21
Patient0.250.930.821.05
Constant0.67
DOI: https://doi.org/10.1515/bjmg-2016-0001 | Journal eISSN: 2199-5761
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Language: English
Page range: 5 - 12
Published on: Aug 2, 2016
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
AMHR2 gene,
Cumulus cells (CC),
Embryo prediction,
LIF gene,
In vitro fertilization (IVF)
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2016 R Devjak, T Burnik Papler, I Verdenik, K Fon Tacer, E Vrtačnik Bokal, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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