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Variants in mitochondrial tRNA gene may not be associated with thyroid carcinoma Cover

Variants in mitochondrial tRNA gene may not be associated with thyroid carcinoma

By: F Lv,  G Qian,  W You,  H Lin,  XF Wang,  GS Qiu,  YS Jiang,  LX Pang,  YM Kang,  BF Jia,  JZ Xu and  Y Yu  
Open Access
|Jul 2016

Figures & Tables

Mitochondrial tRNA mutations with standard nt numbering, arrows indicate the locations of mt-tRNA variants.
Mitochondrial tRNA mutations with standard nt numbering, arrows indicate the locations of mt-tRNA variants.
Phylogenetic conservation analysis of the A12308G variant (the arrow shows position 44 that corresponds to the A12308G variant).
Phylogenetic conservation analysis of the A12308G variant (the arrow shows position 44 that corresponds to the A12308G variant).

Molecular characterization of mt-tRNA variants for thyroid cancer_

tRNAtRNAAsptRNAArgtRNALeu(CUN)tRNAIletRNAAla
Nt changesG7521AT10411CT10463CA12308GG4292CC4312TT5655C
Number of nts in tRNA47674434541
Positionacceptor armacceptor armacceptor armvariable loopanticodon armT armacceptor arm
Homoplasmy/heteroplasmyhomoplasmyhomoplasmyhomoplasmyhomoplasmyhomoplasmyhomoplasmyhomoplasmy
CI (%)13.521.194.293.310.019.071.2
G (wild type)(kcal/mol)‒10.59‒10.58‒10.86‒16.01‒8.98‒8.98‒18.47
G (mutant)(kcal/mol)‒11.11‒10.13‒10.13‒15.88‒9.06‒9.12‒18.81
Language: English
Page range: 59 - 64
Published on: Jul 9, 2016
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2016 F Lv, G Qian, W You, H Lin, XF Wang, GS Qiu, YS Jiang, LX Pang, YM Kang, BF Jia, JZ Xu, Y Yu, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.