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Nanoparticle interaction with the immune system / Interakcije nanodelcev z imunskim sistemom Cover

Nanoparticle interaction with the immune system / Interakcije nanodelcev z imunskim sistemom

Open Access
|Jun 2015

References

  1. 1. Gartman A, Findlay AJ, Luther GW. Nanoparticulate pyrite and other nanoparticles are a widespread component of hydrothermal vent black smoker emissions. Chem Geol 2014;336:32-41. doi: 10.1016/j.chemgeo.2013.12.013
  2. 2. Wise JP, Goodale BC, Wise SS, Craig GA, Pongan AF, Walter RB, Thompson WD, Ng AK, Aboueissa AM, Mitani H, Spalding MJ, Mason MD. Silver nanospheres are cytotoxic and genotoxic to fish cells. Aquat Toxicol 2010;97:34-41. doi: 10.1016/j.aquatox.2009.11.016
  3. 3. Ngô C, Van de Voorde MH. Nanotechnology in a Nutshell: From Simple to Complex Systems. Paris: Atlantis Press; 2014.
  4. 4. Donaldson K, Poland CA, Schins RPF. Possible genotoxic mechanisms of nanoparticles: Criteria for improved test strategies. Nanotoxicology 2010;4:414-20. doi: 10.3109/17435390.2010.482751
  5. 5. Coradeghini R, Gioria S, Garcia CP, Nativo P, Franchini F, Gilliland D, Ponti J, Rossi F. Size-dependent toxicity and cell interaction mechanisms of gold nanoparticles on mouse fibroblasts. Toxicol Lett 2013;217:205-16. doi: 10.1016/j. toxlet.2012.11.022
  6. 6. Shang L, Nienhaus K, Nienhaus GU. Engineered nanoparticles interacting with cells: size matters. J Nanobiotechnol 2014;12:5. doi: 10.1186/1477-3155-12-5
  7. 7. Toyooka T, Amano T, Ibuki Y. Titanium dioxide particles phos-phorylate histone H2AX independent of ROS production. Mutat Res 2012;742:84-91. doi: 10.1016/j. mrgentox.2011.12.015
  8. 8. Ingle AP, Duran N, Rai M. Bioactivity, mechanism of action, and cytotoxicity of copper-based nanoparticles: a review. Appl Microbiol Biotechnol 2014;98:1001-9. doi: 10.1007/ s00253-013-5422-8
  9. 9. Kroll A, Dierker C, Rommel C, Hahn D, Wohlleben W, Schulze-Isfort C, Göbbert C, Voetz M, Hardinghaus F, Schnekenburger J. Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays. Part Fibre Toxicol 2011;8:9. doi: 10.1186/1743-8977-8-9
  10. 10. Lewinski N, Colvin V, Drezek R. Cytotoxicity of nanoparticles. Small 2008;4:26-49. doi: 10.1002/smll.200700595
  11. 11. Przybytkowski E, Behrendt M, Dubois D, Maysinger D. Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability. FEBS J 2009;276:6204-17. doi: 10.1111/j.1742- 4658.2009. 07324.x
  12. 12. Saptarshi SR, Feltis BN, Wright PF, Lopata AL. Investigating the immunomodulatory nature of zinc oxide nanoparticles at sub-cytotoxic levels in vitro and after intranasal instillation in vivo. J Nanobiotechnol 2015;13:6. doi:10.1186/s12951-015-0067-7
  13. 13. Kawata K, Osawa M, Okabe S. In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells. Environ Sci Technol 2009;43:6046-51. doi: 10.1021/es900754q
  14. 14. Dworak N, Wnuk M, Zebrowski J, Bartosz G, Lewinska A. Genotoxic and mutagenic activity of diamond nanoparticles in human peripheral lymphocytes in vitro. Carbon 2014;68:763-76 doi:10.1016/j.carbon.2013.11.067
  15. 15. Zolnik BS, González-Fernández A, Sadrieh N, Dobrovolskaia MA. Nanoparticles and the immune system. Endocrinology 2010;151:458-65. doi: 10.1210/en.2009-1082
  16. 16. Klippstein R, Fernandez-Montesinos R, Castillo PM, Zaderenko AP, Pozo D. Silver nanoparticles interactions with the immune system: implications for health and disease. In: Pozo Perez D, editor. Silver nanoparticles. 1st ed. Rijeka: In TechOpen; 2010. p. 309-24.
  17. 17. Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 2005;5:243-51. doi: 10.1038/nri1571
  18. 18. Cupaioli FA, Zucca FA, Boraschi D, Zecca L. Engineered nanoparticles. How brain friendly is this new guest? Prog Neuroboil 2014;119-120:20-38. doi: 10.1016/j. pneurobio.2014.05.002
  19. 19. Smith MJ, Brown JM, Zamboni WC, Walker NJ. From immunotoxicity to nanotherapy: the effects of nanomaterials on the immune system. Toxicol Sci 2014;138:249-55. doi: 10.1093/toxsci/kfu005
  20. 20. Dobrovolskaia MA, McNeil SE. Immunological properties of engineered nanomaterials. Nat Nanotechnol 2007;2:469-78. doi: 10.1038/nnano.2007.223
  21. 21. Dwivedi PD, Misra A, Shanker R, Das M. Are nanomaterials a threat to the immune system? Nanotoxicology 2009;3:19-26. doi: 10.1080/17435390802604276
  22. 22. Lucarelli M, Gatti AM, Savarino G, Quattroni P, Martinelli L, Monari E, Boraschi D. Innate defence functions of macrophages can be biased by nano-sized ceramic and metallic particles. Eur Cytokine Netw 2004;15:339-46. PMID: 15627643
  23. 23. Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Oldenburg SJ, Paule MG, Slikker W Jr, Hussain SM, Ali SF. Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells. Toxicol Sci 2010;118:160-70. doi: 10.1093/toxsci/kfq244
  24. 24. Chuang HC, Chenc LC, Leic YC, Wuc KY, Fengb PH, Chengc TJ. Surface area as a dose metric for carbon black nanoparticles: A study of oxidative stress, DNA singlestrand breakage and inflammation in rats. Atmos Environ 2015;106:329-34. doi:10.1016/j.atmosenv.2015.02.014
  25. 25. Xia T, Kovochich M, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2008;2:2121-34. doi: 10.1021/nn800511k
  26. 26. Park EJ, Kim H, Kim Y, Yi J, Choi K, Park K. Inflammatory responses may be induced by a single intratracheal instillation of iron nanoparticles in mice. Toxicology 2010;275:65-71. doi: 10.1016/j.tox.2010.06.002
  27. 27. Kaewamatawong T, Shimada A, Okajima M, Inoue H, Morita T, Inoue K, Takano H. Acute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillation. Toxicol Pathol 2006;34:958-65. doi: 10.1080/01926230601094552
  28. 28. Nishimori H, Kondoh M, Isoda K, Tsunoda S, Tsutsumi Y, Yagi K. Silica nanoparticles as hepatotoxicants. Eur J Pharm Biopharm 2009;72:496-501. doi: 10.1016/j.ejpb.2009.02.005
  29. 29. Cho WS, Kim S, Han BS, Son WC, Jeong J. Comparison of gene expression profiles in mice liver following intravenous injection of 4 and 100 nm-sized PEG-coated gold nanoparticles. Toxicol Lett 2009;191:96-102. doi: 10.1016/j. toxlet.2009.08.010
  30. 30. Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Arepalli S, Schwegler- Berry D, Hubbs AF, Antonini J, Evans DE, Ku BK, Ramsey D, Maynard A, Kagan VE, Castranova V, Baron P. Unusual inflammatory and fibrogenic pulmonary responses to singlewalled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 2005;289:L698-708. doi: 10.1152/ ajplung.00084.2005
  31. 31. Pulskamp K, Diabaté S, Krug HF. Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 2007;168:58-74. doi: 10.1016/j.toxlet.2006.11.001
  32. 32. Shvedova AA, Fabisiak JP, Kisin ER, Murray AR, Roberts JR, Tyurina YY, Antonini JM, Feng WH, Kommineni C, Reynolds J, Barchowsky A, Castranova V, Kagan VE. Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am J Respir Cell Mol Biol 2008;38:579-90. doi: 10.1165/ rcmb.2007-0255OC
  33. 33. Andersen AJ, Robinson JT, Dai HJ, Hunter AC, Andresen TL, Moghimi SM. Single-walled carbon nanotube surface control of complement recognition and activation. ACS Nano 2013;7:1108-19. doi: 10.1021/nn3055175
  34. 34. Dykman LA, Sumaroka MV, Staroverov SA, Zaitseva IS, Bogatyrev VA. Immunogenic properties of the colloidal gold. Biol Bull 2004;31:75-9. doi: 10.1023/B:BIBU.0000014358. 98422.9c
  35. 35. Hamad I, Christy Hunter A, Rutt KJ, Liu Z, Dai H, Moein Moghimi S. Complement activation by PEGylated singlewalled carbon nanotubes is independent of C1q and alternative pathway turnover. Mol Immunol 2008;45:3797-803. doi: 10.1016/j.molimm.2008.05.020
  36. 36. Pedersen MB, Zhou X, Larsen EK, Sorensen US, Kjems J, Nygaard JV, Nyengaard JR, Meyer RL, Boesen T, Vorup- Jensen T. Curvature of synthetic and natural surfaces is an important target feature in classical pathway complement activation. J Immunol 2010;184:1931-45. doi: 10.4049/ jimmunol.0902214
  37. 37. Pham CT, Mitchell LM, Huang JL, Lubniewski CM, Schall OF, Killgore JK, Pan D, Wickline SA, Lanza GM, Hourcade DE. Variable antibody-dependent activation of complement by functionalized phospholipid nanoparticle surfaces. J Biol Chem 2011;286:123-30. doi: 10.1074/jbc.M110.180760
  38. 38. Pondman KM, Sobik M, Nayak A, Tsolaki AG, Jäkel A, Flahaut E, Hampel S, Ten Haken B, Sim RB, Kishore U. Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages. Nanomedicine 2014;10:1287-99. doi: 10.1016/j. nano.2014.02.010
  39. 39. Salvador-Morales C, Flahaut E, Sim E, Sloan J, Green ML, Sim RB. Complement activation and protein adsorption by carbon nanotubes. Mol Immunol 2006;43:193-201. doi: 10.1016/j.molimm.2005.02.006
  40. 40. Salvador-Morales C, Basiuk EV, Basiuk VA, Green ML, Sim RB. Effects of covalent functionalization on the biocompatibility characteristics of multi-walled carbon nanotubes. J Nanosci Nanotechnol 2008;8:2347-56. doi: 10.1166/jnn.2008.090
  41. 41. Dobrovolskaia MA, Neun BW, Man S, Ye X, Hansen M, Patri AK, Crist RM, McNeil SE. Protein corona composition does not accurately predict hematocompatibility of colloidal gold nanoparticles. Nanomedicine 2014;10:1453-63. doi: 10.1016/j.nano.2014.01.009
  42. 42. Liu Y, Jiao F, Qiu Y, Li W, Qu Y, Tian C, Li Y, Bai R, Lao F, Zhao Y, Chai Z, Chen C. Immunostimulatory properties and enhanced TNF- alpha mediated cellular immunity for tumor therapy by C60(OH)20 nanoparticles. Nanotechnology 2009;20:415102. doi: 10.1088/0957-4484/20/41/415102
  43. 43. Chen BX, Wilson SR, Das N, Coughlin DJ, Erlanger BF. Antigenicity of fullerenes: Antibodies specific for fullerenes and their characteristics. Proc Natl Acad Sci USA 1998;95:10809-13. doi: 10.1073/pnas.95.18.10809
  44. 44. Andreev SM, Babakhin AA, Petrukhina AO, Romanova VS, Parnes ZN, Petrov RV. Immunogenic and allergenic properties of fulleren conjugates with aminoacids and proteins. Dokl Biochem 2000;370:4-7. PMID: 11977250
  45. 45. Castignolles N, Morgeaux S, Gontier-Jallet C, Samain D, Betbeder D, Perrin P. A new family of carriers (biovectors) enhances the immunogenicity of rabies antigens. Vaccine 1996;14:1353-60. doi: 10.1016/S0264-410X(96)00043-6
  46. 46. de Haar C, Hassing I, Bol M, Bleumink R, Pieters R. Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clin Exp Allergy 2006;36:1469-79. doi: 10.1111/j.1365-2222.2006.02586.x
  47. 47. Niikura K, Matsunaga T, Suzuki T, Kobayashi S, Yamaguchi H, Orba Y, Kawaguchi A, Haegawa H, Kajino K, Ninomiya T, Ijiro K, Sawa H. Gold nanoparticles as a vaccine platform: Influence of size and shape on immunological responses in vitro and in vivo. ACS Nano 2013;7:3926-38. doi: 10.1021/ nn3057005
  48. 48. Rajananthanan P, Attard GS, Sheikh NA, Morrow WJ. Evaluation of novel aggregate structures as adjuvants: composition, toxicity studies and humoral responses. Vaccine 1999;17:715-30. doi: 10.1016/S0264-410X(98)00256-4
  49. 49. Stieneker F, Kreuter J, Löwer J. 1991. High antibody titres in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines. AIDS 1991;5:431-5. doi: 10.1097/00002030-199104000-00012
  50. 50. Li X, Aldayel AM, Cui Z. Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles. J Control Release 2014;173:148-57. doi: 10.1016/j.jconrel.2013.10.032
  51. 51. Sun B, Ji Z, Liao YP, Wang M, Wang X, Dong J, Chang CH, Li R, Zhang H, Nel AE, Xia T. Engineering an effective immune adjuvant by designed control of shape and crystallinity of aluminum oxyhydroxide nanoparticles. ACS Nano 2013;7:10834-49. doi: 10.1021/nn404211j
  52. 52. Cao Y, Ma Y, Zhang M, Wang H, Tu X, Shen H, Dai J, Guo H, Zhang Z. Ultrasmall graphene oxide supported gold nanoparticles as adjuvants improve humoral and cellular immunity in mice. Adv Funct Mater 2014;24:6963-71. doi: 10.1002/adfm.201401358
  53. 53. Al-Humadi NH, Siegel PD, Lewis DM, Barger MW, Ma JY, Weissman DN, Ma JK. The effect of diesel exhaust particles (DEP) and carbon black (CB) on thiol changes in pulmonary ovalbumin allergic sensitized Brown Norway rats. Exp Lung Res 2002;28:333-49. doi: 10.1080/01902140290091976
  54. 54. Nel AE, Diaz-Sanchez D, Ng D, Hiura T, Saxon A. Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol 1998; 102:539-54. doi: 10.1016/ S0091-6749(98)70269-6
  55. 55. Nygaard UC, Hansen JS, Samuelsen M, Alberg T, Marioara CD, Løvik M. Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice. Toxicol Sci 2009;109:113-23. doi: 10.1093/toxsci/kfp057
  56. 56. Ryan JJ, Bateman HR, Stover A, Gomez G, Norton SK, Zhao W, Schwartz LB, Lenk R, Kepley CL. Fullerene nanomaterials inhibit the allergic response. J Immunol 2007;179:665-72. PMID: 17579089
  57. 57. Chen EY, Garnica M, Wang YC, Mintz AJ, Chen CS, Chin WC. A mixture of anatase and rutile TiOnanoparticles induces histamine secretion in mast cells. Part Fibre Toxicol 2012;9:2. doi: 10.1186/1743-8977-9-2
  58. 58. Katwa P, Wang X, Urankar RN, Podila R, Hilderbrand SC, Fick RB, Rao AM, Ke PC, Wingard CJ, Brown JM. A carbon nanotube toxicity paradigm driven by mast cells and the IL-33/ST2 axis. Small 2012;8:2904-12. doi: 10.1002/ smll.201200873
  59. 59. Murray AR, Kisin E, Leonard SS, Young SH, Kommineni C, Kagan VE, Castranova V, Shvedova AA. Oxidative stress and inflammatory response in dermal toxicity of singlewalled carbon nanotubes. Toxicology 2009;257:161-71. doi: 10.1016/j.tox.2008.12.023
  60. 60. Shannahan JH, Kodavanti UP, Brown JM. Manufactured and airborne nanoparticle cardiopulmonary interactions: A review of mechanisms and the possible contribution of mast cells. Inhal Toxicol 2012;24: 320-39. doi: 10.3109/08958378.2012.668229
  61. 61. Wang X, Katwa P, Podila R, Chen P, Ke PC, Rao AM, Walters DM, Wingard CJ, Brown JM. Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice. Part Fibre Toxicol 2011;8:24. doi: 10.1186/1743-8977-8-24
  62. 62. Azzi J, Tang L, Moore R, Tong R, Haddad NE, Akiyoshi T, Mfarrej B, Yang S, Jurewicz M, Ichimura T, Lindeman N, Cheng J, Abdi R. Polylactide-cyclosporin A nanoparticles for targeted immunosuppression. FASEB J 2010;24:3927-38. doi: 10.1096/fj.10-154690
  63. 63. Higaki M, Ishihara T, Izumo N, Takatsu M, Mizushima Y. Treatment of experimental arthritis with poly(D, L-lactic/ glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate. Ann Rheum Dis 2005;64:1132-6. doi: 10.1136/ard.2004.030759
  64. 64. Xu W, Ling P, Zhang T. Toward immunosuppressive effects on liver transplantation in rat model: tacrolimus loaded poly(ethylene glycol)-poly(D,L-lactide) nanoparticle with longer survival time. Int J Pharm 2014;460:173-80. doi: 10.1016/j.ijpharm.2013.10.035
  65. 65. Shen CC, Wang CC, Liao MH, Jan TR. A single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB/c mice. Int J Nanomedicine 2011;6:1229-35. doi: 10.2147/IJN.S21019
  66. 66. Mitchell LA, Gao J, Wal RV, Gigliotti A, Burchiel SW, McDonald JD. Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci 2007;100:203-14. doi: 10.1093/toxsci/kfm196
  67. 67. Mitchell LA, Lauer FT, Burchiel SW, McDonald JD. Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice. Nat Nanotechnol 2009;4:451-6. doi: 10.1038/NNANO.2009.151
  68. 68. Hirst SM, Peairs AD, Gogal R, Seal S, Reilly CM. Cerium oxide nanoparticles decrease inflammation in J774 cells. FASEB J 2008;22(Meeting Abstracts):758.2.
  69. 69. Shaunak S, Thomas S, Gianasi E, Godwin A, Jones E, Teo I, Mireskandari K, Luthert P, Duncan R, Patterson S, Khaw P, Brocchini S. Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation. Nat Biotechnol 2004;22:977-84. doi: 10.1038/nbt995
  70. 70. John AE, Lukacs NW, Berlin AA, Palecanda A, Bargatze RF, Stoolman LM, Nagy JO. Discovery of a potent nanoparticle P-selectin antagonist with anti-inflammatory effects in allergic airway disease. FASEB J 2003;17:2296-8. doi: 10.1096/fj.03-0166fje
  71. 71. Magdolenova Z, Collins A, Kumar A, Dhawan A, Stone V, Dusinska M. Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles. Nanotoxicology 2014; 8: 233-78. doi: 10.3109/17435390.2013.773464
  72. 72. Warheit DB. How meaningful are the results of nanotoxicity studies in the absence of adequate material characterization? Toxicol Sci 2008:101;183-5. doi: 10.1093/toxsci/kfm279
  73. 73. Brun NR, Lenz M, Wehrli B, Fent K. Comparative effects of zinc oxide nanoparticles and dissolved zinc on zebrafish embryos and eleuthero-embryos: importance of zinc ions. Sci Total Environ 2014;476-477:657-66. doi: 10.1016/j. scitotenv.2014.01.053
  74. 74. Brunner TJ, Wick P, Manser P, Spohn P, Grass RN, Limbach LK, Bruinink A, Stark WJ. In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. Environ Sci Technol 2006;40:4374-81. doi: 10.1021/es052069i
  75. 75. Lin W, Xu Y, Huang CC, Ma Y, Shannon KB, Chen DR, Huang YW. Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells. J Nanopart Res 2009;11:25-39. doi: 10.1007/s11051-008-9419-7
  76. 76. Petrarca C, Perrone A, Verna N, Verginelli F, Ponti J, Sabbioni E, Di Giampaolo L, Dadorante V, Schiavone C, Boscolo P, Mariani Costantini R, Di Gioacchino M. Cobalt nanoparticles modulate cytokine in vitro release by human mononuclear cells mimicking autoimmune disease. Int J Immunopathol Pharmacol 2006;19(4 Suppl):11-4. PMID: 17291400
  77. 77. Reale M, Vianale G, Lotti LV, Mariani-Costantini R, Perconti S, Cristaudo A, Leopold K, Antonucci A, Di Giampaolo L, Iavicoli I, Di Gioacchino M, Boscolo P. Effects of palladium nanoparticles on the cytokine release from peripheral blood mononuclear cells of palladium-sensitized women. J Occup Environ Med 2011;53:1054-60. doi: 10.1097/ JOM.0b013e318228115e
  78. 78. Ariano P, Zamburlin P, Gilardino A, Mortera R, Onida B, Tomatis M, Ghiazza M, Fubini B, Lovisolo D. Interaction of spherical silica nanoparticles with neuronal cells: sizedependent toxicity and perturbation of calcium homeostasis. Small 2011;7:766-74. doi: 10.1002/smll.201002287
  79. 79. Fifis T, Gamvrellis A, Crimeen-Irwin B, Pietersz GA, Li J, Mottram PL, McKenzie IF, Plebanski M. Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors. J Immunol 2004;173:3148-54. doi: 10.4049/jimmunol.173.5.3148
  80. 80. Inoue K, Takano H, Yanagisawa R, Koike E, Shimada A. Size effects of latex nanomaterials on lung inflammation in mice. Toxicol Appl Pharmacol 2009;234:68-76. doi: 10.1016/j.taap.2008.09.012
  81. 81. Mottram PL, Leong D, Crimeen-Irwin B, Gloster S, Xiang SD, Meanger J, Ghildyal R, Vardaxis N, Plebanski M. Type 1 and 2 immunity following vaccination is influenced by nanoparticle size: formulation of a model vaccine for respiratory syncytial virus. Mol Pharm 2007;4:73-84. doi: 10.1021/mp060096p
  82. 82. Pan Y, Neuss S, Leifert A, Fischler M, Wen F, Simon U, Schmid G, Brandau W, Jahnen-Dechent W. Size-dependent cytotoxicity of gold nanoparticles. Small 2007;3:1941-9. doi: 10.1002/smll.200700378
  83. 83. Schöler N, Hahn H, Müller RH, Liesenfeld O. Effect of lipid matrix and size of solid lipid nanoparticles (SLN) on the viability and cytokine production of macrophages. Int J Pharm 2002;231:167-76. doi: 10.1016/S0378-5173(01)00882-1
  84. 84. Yang H, Liu C, Yang D, Zhang H, Xi Z. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol 2009;29:69-78. doi: 10.1002/jat.1385
  85. 85. Radomski A, Jurasz P, Alonso-Escolano D, Drews M, Morandi M, Malinski T, Radomski MW. Nanoparticleinduced platelet aggregation and vascular thrombosis. Br J Pharmacol 2005;146:882-93. doi: 10.1038/sj.bjp.0706386
  86. 86. Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong Y. DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol Appl Pharmacol 2008;233:404-10. doi: 10.1016/j. taap.2008.09.015
  87. 87. Lee WM, An YJ,Yoon H, Kweon HS. Toxicity and bioavailability of copper nanoparticles to the terrestrial plants mung bean (Phaseolus radiatus) and wheat (Triticum aestivum): plant agar test for water-insoluble nanoparticles. Environ Toxicol Chem 2008;27:1915-21. doi: 10.1897/07-481.1
  88. 88. Schöler N, Olbrich C, Tabatt K, Müller RH, Hahn H, Liesenfeld O. Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages. Int J Pharm 2001;221:57-67. PMID: 11397567
  89. 89. Vallhov H, Qin J, Johansson SM, Ahlborg N, Muhammed MA, Scheynius A, Gabrielsson S. The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications. Nano Lett 2006;6:1682-6. doi: 10.1021/nl060860z
  90. 90. Fedeli C, Segat D, Tavano R, De Franceschi G, de Laureto PP, Lubian E, Selvestrel F, Mancin F, Papini E. Variations of the corona HDL:albumin ratio determine distinct effects of amorphous SiOnanoparticles on monocytes and macrophages in serum. Nanomedicine (Lond) 2014; 9:2481-97. PMID: 24661258
  91. 91. Tenzer S, Docter D, Kuharev J, Musyanovych A, Fetz V, Hecht R, Schlenk F, Fischer D, Kiouptsi K, Reinhardt C, Landfester K, Schild H, Maskos M, Knauer SK, Stauber RH. Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology. Nat Nanotechnol 2013;8:772-81. doi: 10.1038/nnano.2013.181
  92. 92. Wang F, Yu L, Monopoli MP, Sandin P, Mahon E, Salvati A, Dawson KA. The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes. Nanomedicine 2013;9:1159-68. doi: 10.1016/j. nano.2013.04.010
  93. 93. Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R. Biodegradable long-circulating polymeric nanospheres. Science 1994;263:1600-3. doi: 10.1126/ science.8128245
  94. 94. Costantini LM, Gilberti RM, Knecht DA. The phagocytosis and toxicity of amorphous silica. PLoS One 2011;6:e14647. doi: 10.1371/journal.pone.0014647
  95. 95. Dujmović IH. Comparison of two guidelines on immunotoxicity testing of medicinal products. Arh Hig Rada Toksikol 2005;56:265-8. PMID: 16180612
  96. 96. Kawabata TT, Evans EW. Development of immunotoxicity testing strategies for immunomodulatory drugs. Toxicol Pathol 2012;40:288-93. doi: 10.1177/0192623311430238
  97. 97. Lankveld DP, Van Loveren H, Baken KA, Vandebriel RJ. In vitro testing for direct immunotoxicity: state of the art. Methods Mol Biol 2010;598:401-23. doi: 10.1007/978-1-60761-401-2_26
  98. 98. Luebke R. Immunotoxicant screening and prioritization in the twenty-first century. Toxicol Pathol 2012;40:294-9. doi: 10.1177/0192623311427572
  99. 99. Luster MI, Portier C, Pait DG, White KL Jr, Gennings C, Munson AE, Rosenthal GJ. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam Appl Toxicol 1992;18:200-10. doi: 10.1016/0272-0590(92)90047-L
  100. 100. Ong KJ, MacCormack TJ, Clark RJ, Ede JD, Ortega VA, Felix LC, Dang MKM, Ma G, Fenniri H, Veinot JGC, Goss GG. Widespread nanoparticle-assay interference: implications for nanotoxicity testing. PLoS ONE 2014;9:e90650. doi: 10.1371/journal.pone.0090650
  101. 101. Wörle-Knirsch JM, Pulskamp K, Krug HF. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett 2006;6:1261-8. doi: 10.1021/nl060177c
  102. 102. Oostingh GJ, Casals E, Italiani P, Colognato R, Stritzinger R, Ponti J, Pfaller T, Kohl Y, Ooms D, Favilli F, Leppens H, Lucchesi D, Rossi F, Nelissen I, Thielecke H, Puntes VF, Duschl A, Boraschi D. Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomo dulatory effects. Part Fibre Toxicol 2011;8:8. doi: 10.1186/1743-8977-8-8
  103. 103. Kroll A, Pillukat MH, Hahn D, Schnekenburger J. Interference of engineered nanoparticles with in vitro toxicity assays. Arch Toxicol 2012;86:1123-36. doi: 10.1007/s00204-012-0837-z
  104. 104. Rajapakse K, Drobne D, Kastelec D, Marinsek-Logar R. Experimental evidence of false-positive Comet test results due to TiOparticle-assay interactions. Nanotoxicology 2013;7:1043-51. doi: 10.3109/17435390.2012.696735
  105. 105. Dobrovolskaia MA, Aggarwal P, Hall JB, McNeil SE. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol Pharm 2008;5:487-95. doi: 10.1021/mp800032f
  106. 106. Dobrovolskaia MA, Germolec DR, Weaver JL. Evaluation of nanoparticle immunotoxicity. Nat Nanotechnol 2009;4:411-4. doi: 10.1038/nnano.2009.175
  107. 107. Dobrovolskaia MA, McNeil SE. Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines. J Control Release 2013;172:456-66. doi: 10.1016/j.jconrel.2013.05.025
  108. 108. Mendoza A, Torres-Hernandez JA, Ault JG, Pedersen-Lane JH, Gao D, Lawrence DA. Silica nanoparticles induce oxidative stress and inflammation of human peripheral blood mononuclear cells. Cell Stress Chaperones 2014;19:777-90. doi: 10.1007/s12192-014-0502-y
  109. 109. Capasso L, Camatini M, Gualtieri M. Nickel oxide nanoparticles induce inflammation and genotoxic effect in lung epithelial cells. Toxicol Lett 2014;226:28-34. doi: 10.1016/j.toxlet.2014.01.040
  110. 110. Yen HJ, Hsu SH, Tsai CL. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small 2009;5:1553-61. doi: 10.1002/smll.200900126
  111. 111. Nemmar A, Albarwani S, Beegam S, Yuvaraju P, Yasin J, Attoub S, Ali BH. Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation. Int J Nanomedicine 2014;9:2779-89. doi: 10.2147/IJN.S52818
  112. 112. Chou CC, Hsiao HY, Hong QS, Chen CH, Peng YW, Chen HW, Yang PC. Single-walled carbon nanotubes can induce pulmonary injury in mouse model. Nano Lett 2008;8:437-45. doi: 10.1021/nl0723634
  113. 113. Nemmar A, Melghit K, Ali BH. The acute proinflammatory and prothrombotic effects of pulmonary exposure to rutile TiO2 nanorods in rats. Exp Biol Med (Maywood) 2008;233:610-9. doi: 10.3181/0706-RM-165
  114. 114. Seiffert J, Hussain F, Guo C, Chang Y, Zhang J, Smith R, Tetley T, Chung F. Inhaled silver nanoparticles induce pulmonary oxidative injury and inflammation: Differential effects between rat strains. Eur Respir J 2014;44(Suppl 58):P3939.
  115. 115. Braakhuis HM, Gosens I, Krystek P, Boere J, Cassee FR, Fokkens P, Post J, van Loveren H, Park M. Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles. Part Fibre Toxicol 2014;11:49. doi: 10.1186/s12989-014-0049-1
  116. 116. Yanagisawa R, Takano H, Inoue K, Koike E, Kamachi T, Sadakane K, Ichinose T. Titanium dioxide nanoparticles aggravate atopic dermatitis-like skin lesions in NC/Nga mice. Exp Biol Med (Maywood) 2009;234:314-22. doi: 10.3181/0810-RM-304
  117. 117. Hirai T, Yoshioka Y, Ichihashi K, Mori T, Nishijima N, Handa T, Takahashi H, Tsunoda S, Higashisaka K, Tsutsumi Y. Silver nanoparticles induce silver nanoparticle-specific allergic responses. J Immunol 2014;192(Suppl 1):118.19.
  118. 118. Ilves M, Palomäki J, Vippola M, Lehto M, Savolainen K, Savinko T, Alenius H. Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model. Part Fibre Toxicol 2014;11:38. doi: 10.1186/s12989-014-0038-4
  119. 119. Herzog E, Byrne HJ, Casey A, Davoren M, Lenz AG, Maier KL, Duschl A, Oostingh GJ. SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro. Toxicol Appl Pharmacol 2009;234:378-90. doi: 10.1016/j. taap.2008.10.015
DOI: https://doi.org/10.1515/aiht-2015-66-2582 | Journal eISSN: 1848-6312 (formerly 0004-1254) | Journal ISSN: 0004-1254
Language: English, Croatian, Slovenian
Page range: 97 - 108
Submitted on: Oct 1, 2014
Accepted on: Apr 1, 2015
Published on: Jun 25, 2015
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services

© 2015 Veno Kononenko, Mojca Narat, Damjana Drobne, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.