Effect of alkan-1-ols on the structure of dopc model membrane

T. Kondela; J. Gallová; T. Hauß; O. Ivankov; N. Kučerka; P. Balgavý

doi:10.1515/afpuc-2017-0010

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Effect of alkan-1-ols on the structure of dopc model membrane

European Pharmaceutical Journal

Volume 64 (2017): Issue 2 (November 2017)

By: T. Kondela, J. Gallová, T. Hauß, O. Ivankov, N. Kučerka and P. Balgavý

Open Access

|Nov 2017

Abstract

The effect of general anaesthetics alkan-1-ols (CnOH, where n = 10, 12, 14, 16 and 18 is the number of carbon atoms in the molecule) on the structure of dioleoylphosphatidylcholine (DOPC) model membrane was studied by small-angle neutron scattering (SANS) and small-angle neutron diffraction (SAND). Fluid bilayers were prepared at CnOH:DOPC = 0.3 molar ratio. The results of both the experiments show that bilayer thickness - a thickness parameter dg in the case of SANS and lamellar repeat distance D in the case of SAND - increases with increasing n. A coexistence of two lamellar phases with different D was detected by measuring the C18OH+DOPC oriented sample.

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Articles in this issue

DOI: https://doi.org/10.1515/afpuc-2017-0010 | Journal eISSN: 2453-6725

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Language: English

Page range: 4 - 8

Submitted on: Jun 20, 2017

Accepted on: Jul 6, 2017

Published on: Nov 30, 2017

Published by: Comenius University in Bratislava, Faculty of Pharmacy

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

Model membrane - general anaesthetics - alkan-1-ols - small-angle neutron scattering - small-angle neutron diffraction - structure

Related subjects:

Pharmacy,

Pharmacy, other

© 2017 T. Kondela, J. Gallová, T. Hauß, O. Ivankov, N. Kučerka, P. Balgavý, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 64 (2017): Issue 2 (November 2017)