Changes in electrical activity of heart during ischemic–reperfusion injury modified by the administration of antidepressants

M. Vicen; P. Gulač; T. Stankovičová

doi:10.1515/afpuc-2016-0006

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Changes in electrical activity of heart during ischemic–reperfusion injury modified by the administration of antidepressants

European Pharmaceutical Journal

Volume 63 (2016): Issue 1 (September 2016)

By: M. Vicen, P. Gulač and T. Stankovičová

Open Access

|Nov 2016

Abstract

The aim of our work was to investigate the effect of amitriptyline, citalopram and venlafaxine on the heart during ischemic- reperfusion (l-R) injury. Amitriptyline prolonged both QRS complex and QTc interval duration; citalopram and venlafaxine prolonged only QTc interval duration. Amitriptyline worked most proarrhythmogenic, citalopram least; venlafaxine increased the heart rate during ischemia; however, prolonged QTc interval at the beginning of reperfusion was followed by serious dysrhythmias.

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Articles in this issue

DOI: https://doi.org/10.1515/afpuc-2016-0006 | Journal eISSN: 2453-6725

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Language: English

Page range: 5 - 8

Submitted on: Jun 19, 2016

Accepted on: Aug 18, 2016

Published on: Nov 23, 2016

Published by: Comenius University in Bratislava, Faculty of Pharmacy

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

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© 2016 M. Vicen, P. Gulač, T. Stankovičová, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 63 (2016): Issue 1 (September 2016)