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Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients Cover

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

Acta Pharmaceutica
Volume 66 (2016): Issue 3 (September 2016)
By: ,   and    
Open Access
|Jun 2016
References

References

  1. 1. B. B. Sheth, F. J. Bandelin, and R. F. Shangraw, Tablets, in Pharmaceutical Dosage Forms (Eds. H. A. Lieberman and L. Lachman), 1st ed., Marcel Dekker, New York 1980, pp. 109-185.
    Search in Google Scholar
  2. 2. P. Davies, Oral Solid Dosage Forms, in Pharmaceutical Preformulation and Formulation (Ed. M. Gibson), 2nd ed., Informa Healthcare, Inc., New York 2009, pp. 367-430.
    Search in Google Scholar
  3. 3. R. J. Roberts, Particulate Analysis: Mechanical properties, in Solid State Characterization of Pharmaceuticals (Eds. R. A. Storey and I. Ymen), 1st ed., John Wiley & Sons, Southern Gate UK 2011, pp. 357-369.
    Open DOISearch in Google Scholar
  4. 4. J. Nordstrom, I. Klevan and G. Alderborn, A protocol for the classification of powder compression characteristics, Eur. J. Pharm. Biopharm. 80 (2012) 209-216 DOI: 10.1016/j.ejpb.2011.09.006.
    Open DOISearch in Google Scholar
  5. 5. G. E. Amidon, P. J. Secreast and D. Mudie, Particle, Powder, and Compact Characterization, in Developing Solid Dosage Forms (Eds. Y. Qiu, Y. Chen and G. G. Z. Zhang), 1st ed., Elsevier, New York 2009, pp. 163-183.
    Open DOISearch in Google Scholar
  6. 6. C. Sun and D. J. W. Grant, Influence of crystal structure on the tableting properties of sulfamerazine polymorphs, Pharm. Res. 18 (2001) 274-280; DOI: 0724-8741/01/0300-0274.
    Open DOISearch in Google Scholar
  7. 7. S. Jain, Mechanical properties of powders for compaction and tableting: An overview PSST Vol. 2 (1999) 20-31; DOI: 10.1016/S1461-5347(98)00111-4.
    Open DOISearch in Google Scholar
  8. 8. D. Singhal and W. Curatolo, Drug polymorphism and dosage form design: a practical perspective, Adv. Drug Deliv. 56 (2004) 335-347; DOI: 10.1016/j.addr.2003.10.008.
    Open DOISearch in Google Scholar
  9. 9. S. F. Chow, M. Chen, L. Shi, A. H. L. Chow and C. C. Sun, Simultaneously improving the mechanical properties, dissolution performance, and hygroscopicity of ibuprofen and flurbiprofen by cocrystallization with nicotinamide, Pharm. Res. 29 (2012) 1854-1865; DOI: 10.1007/s11095-012-0709-5.
    Open DOISearch in Google Scholar
  10. 10. A. Paradkar and P. York, Crystal Engineering and Particle Design for the Powder Compaction Process, in Pharmaceutical Powder Compaction Technology (Ed. M. Celik), 2nd ed., Informa Healthcare, London 2011, pp. 235-252.
    Search in Google Scholar
  11. 11. N. Blagden, M. de Matas, P. T. Gavan and P. York, Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates, Adv. Drug Deliv. 59 (2007) 617-630; DOI: 10.1016/j.addr.2007.05.011.
    Open DOISearch in Google Scholar
  12. 12. S. Karki, T. Frišič, L. Fabian, P. R. Laity, G .M. Day and W. Jones, Improving mechanical properties of crystalline solids by cocrystal formation: New compressible forms of paracetamol, Adv. Mater. 21 (2009) 3905-3909; DOI: 10.1002/adma.200900533.
    Open DOISearch in Google Scholar
  13. 13. K. L. Johnson, Contact Mechanics (Ed. K. L. Johnson), 1st ed., Cambridge University Press, Cambridge 1985.
    Search in Google Scholar
  14. 14. N. E. Dowling, Mechanical Behaviour of Materials (Ed. N. E. Dowling), 1st ed., Prentice-Hall Inc., New Jersey 1993.
    Search in Google Scholar
  15. 15. K. L. Johnson, The correlation of indentation experiments, J. Mech. Phys. Solids 18 (1970) 115-125; DOI: 10.1016/0022-5096(70)90029-3.
    Open DOISearch in Google Scholar
  16. 16. R. C. Rowe and R. J. Roberts, Mechanical Properties, in Pharmaceutical Powder Compaction Technology (Eds. G. Alderborn and C. Nystrom), 1st ed., Marcel Dekker Inc, New York 1996, pp. 283-322.
    Open DOISearch in Google Scholar
  17. 17. S. W. Hoag, V. S. Dave and V. Moolcandani, Compression and Compaction, in Pharmaceutical Dosage Forms - Tablets (Eds. L. L. Augsburger and S. W. Hoag), 3rd ed., Taylor & Francis Group, New York 2008, pp. 555-631.
    Search in Google Scholar
  18. 18. S. Finnie, K. V. R. Prasad, D. B. Sheen and J. N. Sherwood, Microhardness and dislocation identification studies on paracetamol single crystals, Pharm. Res. 18 (2001) 674-681; DOI: 0724-8741/01/0500-0674.
    Open DOISearch in Google Scholar
  19. 19. M. Radovic, E. Lara-Curzio and L. Riester, Comparison of different experimental techniques for determination of elastic properties of solids, Materials Sci. Engin. A368 (2004) 56-70; DOI: 10.1016/j. msea.2003.09.080.
    Search in Google Scholar
  20. 20. R. W. Heckel, An analysis of powder compaction phenomena, Trans. Metall. Soc. AIME 221 (1961a) 1001-1008.
    Search in Google Scholar
  21. 21. R. W. Heckel, Density-pressure relationships in powder compaction, Trans. Metall. Soc. AIME 221 (1961b) 671-675.
    Search in Google Scholar
  22. 22. E. E. Walker, The properties of powders VI: The compressibility of powders. Trans. Faraday Soc. 19 (1923) 73-82; DOI: 0.1039/tf9231900073.
    Open DOISearch in Google Scholar
  23. 23. K. Kawakita and K. H. Ludde, Some consideration on powder compression equations, Powder Technol. 4 (1971) 61-68; DOI: 10.1016/0032-5910(71)80001-3.
    Open DOISearch in Google Scholar
  24. 24. M. J. Adams, M. A. Mullier and J. P. K. Seville, Agglomerate strength measurement using a uniaxial confined compression test, Powder Technol. 78 (1994) 5-13; DOI: 140.1016/0032-5910(93)02777-8.
    Open DOISearch in Google Scholar
  25. 25. J. S. Smith, M. D. Wyrick and J. M. Poole, An evaluation of three techniques for determining Young’s modulus of mechanically alloyed materials. Dynamic Elastic Modulus Measurements in Materials, ASTM (1990) 195-206; DOI: 10.1520/STP24625S.
    Open DOISearch in Google Scholar
  26. 26. Standard Test Method for Young’s Modulus, Shear Modulus, and Poisson’s Ratio for Glass and Glass-Ceramics by Resonance, Annual Book of ASTM Standards 15 (2006) 623-692.
    Search in Google Scholar
  27. 27. N. A. Armstrong and R. F. Haines-Nutt, Elastic recovery and surface area changes in compacted powder systems, J. Pharm. Pharmacol. 24 (1972) 138-136; DOI: 10.1016/0032-5910(74)80054-9.
    Open DOISearch in Google Scholar
  28. 28. W. C. Duncan-Hewitt and G. C. Weatherly, Evaluating the hardness, Young’s modulus and fracture toughness of some pharmaceutical crystals using microindentation techniques, J. Mater. Sci. 8 (1989) 1350-1352; DOI: 0261-8028/89.
    Search in Google Scholar
  29. 29. M. Celik, Pharmaceutical Powder Compaction Technology, 2nd ed., Informa Healthcare, New York 2011.
    Search in Google Scholar
  30. 30. X. Cao and M. A. Morganti, Study of Hiestand’s “Special Case” Pharmaceutical Materials Using AFM Nanoindentation, 2009, AAPS Annual Meeting and Exposition.
    Search in Google Scholar
  31. 31. D. Olusanmi, K. J. Roberts, M. Ghadiri and Y. Ding, The breakage behaviour of Aspirin under quasi-static indentation and single particle impact loading: Effect of crystallographic anisotropy, Int. J. Pharm. 411 (2011) 49-63; DOI: 10.1016/j.ijpharm.2011.03.039.
    Open DOISearch in Google Scholar
  32. 32. C. C. Kwan, Y. Q. Chen, Y. L. Ding, D. G. Papadopoulos, A. C. Bentham and M .Ghadiri, Development of a novel approach towards predicting the milling behaviour of pharmaceutical powders, Eur. J. Pharm. Sci. 23 (2004) 327-336; DOI: 10.1016/j.ejps.2004.08.006.
    Open DOISearch in Google Scholar
  33. 33. M. Meier, E John, D. Wieckhusen, W. Wirth and W. Peukert, Influence of mechanical properties on impact fracture: Prediction of the milling behaviour of pharmaceutical powders by nanoindentation, Powder Technol. 188 (2009) 301-313; DOI: 101016/j.powtec.2008.05.009.
    Search in Google Scholar
  34. 34. V. M. Masterson and X. Cao, Evaluating particle hardness of pharmaceutical solids using AFM nanoindentation, Int. J. Pharm. 362 (2008) 163-171; DOI: 10.1016/j.ijpharm.2008.06.015.
    Open DOISearch in Google Scholar
  35. 35. A. C. Fischer-Cripps, Nanoindentation, 3rd ed., Springer Verlag, New York 2011.
    Open DOISearch in Google Scholar
  36. 36. X. Liao and T. S. Wiedmann, Measurement of process-dependent material properties of pharmaceutical solids by nNanoindentation, J. Pharm. Sci. 94 (2004) 79-92; DOI: 10.1002/jps.20227.
    Open DOISearch in Google Scholar
  37. 37. S. Varughese, M. S. R. N. Kiran, K. A. Solanko, A. D. Bond, U. Ramamurty and G. R. Desiraju, Interaction anisotropy and shear instability of aspirin polymorphs established by nanoindentation, Chem. Sci. 2 (2011) 2236-2242; DOI: 10.1039/c1sc00430a.
    Open DOISearch in Google Scholar
  38. 38. S. R. Cohen and E. Kalfon-Cohen, Dynamic nanoindentation by instrumented nanoindentation and force microscopy: a comparative review, Beilstein J. Nanotechnol. 4 (2013) 815-833; DOI: 10.3762/ bjnano.4.93.
    Open DOISearch in Google Scholar
  39. 39. E. H. H. Chow, D. K. Bučar and W. Jones, New opportunities in crystal engineering: The role of atomic force microscopy in studies of molecular crystals, Chem. Comm. 48 (2012) 9210-9226; DOI: 10.1039/c2cc32678g.
    Open DOISearch in Google Scholar
  40. 40. E. V. Boldyreva, High-pressure diffraction studies of molecular organic solids. A personal view, Acta Cryst. A64 (2008) 218-231; DOI: 10.1107/S0108767307065786.
    Open DOISearch in Google Scholar
  41. 41. F. P. A. Fabbiani and C. R. Pulham, High-pressure studies of pharmaceutical compounds and energetic materials, Chem. Soc. Rev. 35 (2006) 932-942; DOI: 10.1039/B517780B.
    Open DOISearch in Google Scholar
  42. 42. T. P. Shakhtshneider, E. V. Boldyreva, M. A. Vasilchenko, H. Ahsbahs and H. Uchtmann, Anisotropy of crystal structure distortion in organic molecular crystals of drugs induced by hydrostatic compression, J. Struct. Chem. 40 (1999) 892-898; DOI: 0022-4766/99/4006-0892.
    Open DOISearch in Google Scholar
  43. 43. E. V. Boldyreva, T. P. Shakhtshneider, M. A. Vasilchenko, H. Ahsbahs and H. Uchtmann, Anisotropic crystal structure distortion of the monoclinic polymorph of acetaminophen at high hydrostatic pressure, Acta Cryst. B56 (2000) 299-309; DOI: 10.1107/s0108768199013634.
    Open DOISearch in Google Scholar
  44. 44. T. Beyer, G. M. Day and S. L. Price, The prediction, morphology, and mechanical properties of the polymorphs of paracetamol, J. Am. Chem. Soc. 123 (2001) 5086-5094; DOI: 10.1021/ja0102787.
    Open DOISearch in Google Scholar
  45. 45. M. H. Shariare, F. J. J. Leusen, M. De Matas, P. York and J. Anwar, Prediction of the mechanical behavior of crystalline solids, Pharm. Res. 29 (2012) 319-331; DOI: 10.1007/s11095-011-0543-1.
    Open DOISearch in Google Scholar
  46. 46. C. C. Sun and Y. H. Kiang, On the identification of slip planes in organic crystals based on attachment energy calculation, J. Pharm. Sci. 97 (2007) 3456-3461; DOI: 10.1002/jps.21234.
    Open DOISearch in Google Scholar
  47. 47. M. J. Turner, S. P. Thomas, M. W. S. D. Jayatilaka and M. A. Spackman, Energy frameworks: insights into interaction anisotropy and the mechanical properties of molecular crystals, Chem. Commun. 51 (2015) 3735-3738; DOI: 10.1039/c4cc09074h.
    Open DOISearch in Google Scholar
  48. 48. W. C. Oliver and G. M. Pharr, An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation measurements, J. Mater. Res. 7 (1992) 1564-1583; DOI: 10.1557/JMR.1992.1564.
    Open DOISearch in Google Scholar
  49. 49. W. C. Oliver and G. M. Pharr, Measurement of hardness and elastic modulus by instrumented indentation: Advances in understanding and refinements to methodology, J. Mater. Res. 19 (2004) 3-20; DOI: 10.1557/jmr.2004.0002.
    Open DOISearch in Google Scholar
  50. 50. C. M. Reddy, G. R. Krishna and S. Ghosh, Mechanical properties of molecular crystals: Applications to crystal engineering, Cryst. Eng. Comm. 12 (2010) 2296-2314; DOI: 10.1039/c003466e.
    Open DOISearch in Google Scholar
  51. 51. U. Ramamurty and J. Jang, Nanoindentation for probing the mechanical behavior of molecular crystals: A review of the technique and how to use it, Cryst. Engin. Comm. 16 (2014) 12-23; DOI: 10.1039/c3ce41266k.
    Open DOISearch in Google Scholar
  52. 52. D. A. Lucca, K. Herrmann and M. J. Klopfstein, Nanoindentation: Measuring methods and applications, Manuf. Tech. 59 (2010) 803-819; DOI: 10.1016/j.cirp.2010.05.009.
    Open DOISearch in Google Scholar
  53. 53. http://www.csm-instruments.com/ Why is Nanoindentation more quantitative than AFM for measurement of surface mechanical properties?; access date January 25, 2014.
    Search in Google Scholar
  54. 54. X. Li and B. Bhushan, A review of nanoindentation continuous stiffness measurement technique and its application, Mater. Charact. 48 (2002) 11-36; DOI: org/10.1016/S1044-5803(02)00192-4.
    Open DOISearch in Google Scholar
  55. 55. S. P. Baker, Nanoindentation Techniques, in Encyclopedia of materials: Science and Technology (Eds. K. H. J. Buschow, R. C. Cahn, M. C. Flemings, B. Ilschner, E.J. Kramer and S. Mahajan), Elsevier, New York 2001, pp. 5908-5915.
    Search in Google Scholar
  56. 56. Agilent Technologies, How to select the correct indenter tip, Agilent Technologies, Inc. 2009, USA.
    Search in Google Scholar
  57. 57. CSM Instruments, Nanoindentation approach to mechanical testing of extremely soft materials, CSM Instruments, No 35, June 2011, Switzerland.
    Search in Google Scholar
  58. 58. S. Varughese, M. S. R. N. Kiran, U. Ramamurty and G. R. Desiraju, Nanoindentation in crystal engineering: quantifying mechanical properties of molecular crystals, Angew. Chem. Int. Ed. 52 (2013) 2701-2712; DOI: 10.1002/anie.201205002.
    Open DOISearch in Google Scholar
  59. 59. C. A. Schuh, Nanoindentation studies of materials, Materials Today 9 (2006) 32-40; DOI: 10.1016/ S1369-7021(06)71495-X.
    Open DOISearch in Google Scholar
  60. 60. A. C. Fischer-Cripps, Critical review of analysis and interpretation of nanoindentation test data, Surface & Coatings Tech. 200 (2006) 4153-4165; DOI: 10.1016/j.surfcoat.2005.03.018.
    Open DOISearch in Google Scholar
  61. 61. E. Rettler, S. Hoeppener, B. W. Sigusch and U. S. Schubert, Mapping the mechanical properties of biomaterials on different length scales: depth-sensing indentation and AFM based nanoindentation, J. Mater. Chem. B1 (2013) 2789-2806; DOI: 10.1039/c3tb20120a.
    Open DOISearch in Google Scholar
  62. 62. M. Egart, I. Ilić, B. Janković, N. Lah and S. Srčič, Compaction properties of crystalline pharmaceutical ingredients according to the Walker model and nanomechanical attributes, Int. J. Pharm. 472 (2014b) 347-355; DOI: 10.1016/j.ijpharm.2014.06.047.
    Open DOISearch in Google Scholar
  63. 63. http://www.iso.org/iso/iso_catalogue/catalogue_tc/catalogue_detail.htm?csnumber=3054; access date June 20, 2013.
    Search in Google Scholar
  64. 64. http://www.astm.org/Standards/E2546.htm.
    Search in Google Scholar
  65. 65. Agilent Nano Indenter G200, User’s Guide, Agilent Technologies, 2009.
    Search in Google Scholar
  66. 66. Agilent Technologies, Nanoindentation, scratch, and elevated temperature testing of cellulose and PMMA films, Agilent Technologies, Inc. 2010, USA.
    Search in Google Scholar
  67. 67. H. Hertz, Über die Berührung fester elastischer Körper, J. Reine Angew. Mathematik 92 (1894) 156-171.
    Search in Google Scholar
  68. 68. T. Chudoba and F. Richter, Investigation of creep behavior under load during indentation experiments and its influence on hardness and modulus results, Surface Coatings Technol. 148 (2001) 191-198; DOI: 10.1016/S0257-8972(01)01340-8.
    Open DOISearch in Google Scholar
  69. 69. G. Feng and A. H. W. Ngan, Effects of creep and thermal drift on modulus measurement using depth-sensing indentation, J. Mater. Res. 17 (2002) 660-668; DOI: 010.1016/j.actbio.2014.08.004.
    Open DOISearch in Google Scholar
  70. 70. I. N. Sneddon, The relation between load and penetration in the axisymmetric Boussinesq problem for a punch of arbitrary profile, Int. J. Eng. Sci. 3 (1965) 47-57; DOI: 10.1016/0020-72225(65)900019-4.
    Search in Google Scholar
  71. 71. K. J. Ramos and D. F. Bhar, Mechanical behavior assessment of sucrose using nanoindentation, J. Mater. Res. 7 (2007) 2037-2045; DOI: 10.1557/JMR.2007.0249.
    Open DOISearch in Google Scholar
  72. 72. M. L. Malkowska and K. A. Khan, Effect of recompression on the properties of tablets prepared by dry granulation, Drug. Dev. Ind. Pharm. 9 (1983) 331-347; DOI: 10.3109/03639048309044678.
    Open DOISearch in Google Scholar
  73. 73. S. Inghelbrecht and J. P. Remon, Roller compaction and tableting of microcrystalline cellulose/ drug mixtures, Int. J. Pharm. 161 (1998) 215-224; DOI: 10.1016/S0378-5173(97)00356-6.
    Open DOISearch in Google Scholar
  74. 74. J. Lee, Structural heterogeneity of pharmaceutical compacts probed by micro-indentation, J. Mater. Sci.: Mater. Med. 19 (2008) 1981-1990; DOI: 10.1007/s10856-007-3283-3.
    Open DOISearch in Google Scholar
  75. 75. A. Bolshakov and G. M. Pharr, Influences of pile-up on the measurement of mechanical properties by load and depth sensing indentation techniques, J. Mater. Res. 13 (1998) 1049-1058; DOI: 104910.1557/JMR.1999.0303.
    Open DOISearch in Google Scholar
  76. 76. J. Hay, Introduction to instrumented indentation testing, Experim. Tech. (2009) 66-72; DOI: 10.1111/j. 1747-1567.2009.00541.x.
    Search in Google Scholar
  77. 77. Y. Huang, F. Zhang, K. C. Hwang, W. D. Nix, G. M. Pharr and G. Feng, A model of size effects in nano-indentation, J. Mech. Phys. Solids 54 (2006) 1668-1686; DOI: 10.1016/j.jmps.2006.02.002.
    Open DOISearch in Google Scholar
  78. 78. K. Sangwal, Review: Indentation size effect, indentation cracks and microhardness measurement of brittle crystalline solids - some basic concepts and trends, Cryst. Res. Technol. 44 (2009) 1019-1037; DOI: 10.1002/crat.200900385.
    Open DOISearch in Google Scholar
  79. 79. W. D. Nix and H. Gao, Indentation size effects in crystalline materials: a law for strain gradient plasticity, J. Mech. Phys. Solids 46 (1998) 411-425; DOI: S0022-5096(97)00086-0.
    Search in Google Scholar
  80. 80. Agilent Technologies, Indentation rules of thumb: Applications and limits, Agilent Technologies, Inc. 2010, USA.
    Search in Google Scholar
  81. 81. http://cp.literature.agilent.com/litweb/pdf/5990-5700EN.pdf; Indentation rules of thumb-Applications and Limits, Agilent Technologies; access date October 25, 2015.
    Search in Google Scholar
  82. 82. http://www.iso.org/iso/catalogue_detail.htm?csnumber=30104; Metallic materials-Instrumented indentation test for hardness and materials parameters. ISO 14577-1: 2002; access date October 23, 2015.
    Search in Google Scholar
  83. 83. http://www.nanomechanicsinc.com/index.php/Service-Lab/sample-preparation.html; access date October 25, 2015.
    Search in Google Scholar
  84. 84. http://www.csm-instruments.com/ The influence of surface roughness on instrumented indentation testing (IIT); access date January 25, 2014.
    Search in Google Scholar
  85. 85. K. I. Schiffmann, Determination of fracture toughness of bulk materials and thin films by nanoindentation: comparison of different models, Philosoph. Magazine 91 (2011) 1163-1178; DOI: 10.1080/14786435.2010.487984.
    Open DOISearch in Google Scholar
  86. 86. L. J. Taylor, D. G. Papadopoulos, P. J. Dunn, A. C. Bentham, J. C. Mitchell and M. J. Snowden, Mechanical characterization of powders using nanoindentation, Powder Tech. 143-144 (2004) 179-185; DOI: 10.1016/j.powtec.2004.04.012.
    Open DOISearch in Google Scholar
  87. 87. L. J. Taylor, D. G. Papadopoulos, P. J. Dunn, A. C. Bentham, N. J. Dawson, J. C. Mitchell and M. J. Snowden, Predictive milling of pharmaceutical materials using nanoindentation of single crystals, Org. Process Res. Dev. 8 (2004) 674-679; DOI: 10.1021/op0300241.
    Open DOISearch in Google Scholar
  88. 88. http://cdn.intechweb.org/pdfs/16971.pdf; access date October 25, 2015.
    Search in Google Scholar
  89. 89. M. Ghadiri and Z. Zhang, Impact attrition of particulate solids. Part 1: A theoretical model of chipping, Chem. Engin. Sci. 57 (2002) 3659-3669; DOI: 0009-2509(02)00240-3.
    Open DOISearch in Google Scholar
  90. 90. B. R. Lawn and D. B. Marshall, Hardness, toughness and brittleness: An indentation analysis, J. Am. Ceram. Soc. 62 (1979) 347-350.
    Open DOISearch in Google Scholar
  91. 91. R. V. Haware, P. Kim, L. Ruffino, B. Nimi, C. Fadrowsky, M. Doyle, S. W. X. M. Boerrigter, A. Cuitino and K. Morris, Anisotropic crystal deformation measurements determined using powder X-ray diffraction and a new in situ compression stage, Int. J. Pharm. 418 (2011) 199-206; DOI: 10.1016/j.ijpharm.2011.06.021.
    Open DOISearch in Google Scholar
  92. 92. Y. Feng and D. J. W. Grant, Influence of crystal structure on the compaction properties of n-alkyl 4-hydrokxybenzoate esters (parabens), Pharm. Res. 23 (2006) 1608-1616; DOI: 10.1007/s11095-006-0275-9.
    Open DOISearch in Google Scholar
  93. 93. S. E. David, M. Ramirez, P. Timmins and B. R. Conway, Comparative physical, mechanical and crystallographic properties of a series of gemfibrozil salts, J. Pharm. Pharmacol. 62 (2010) 1519-1525; DOI: 10.11117j.2042-7158.2010.01025.x.
    Open DOISearch in Google Scholar
  94. 94. Y. Feng, J. W. Grant and C. C. Sun, Influence of crystal structure on the tableting properties of n-alkyl 4-hydroxybenzoate esters (parabens), J. Pharm. Sci. 96 (2007) 3324-3333; DOI: 10.1002/ jps.20981.
    Open DOISearch in Google Scholar
  95. 95. R. Bandyopadhyay and D. J. W. Grant, Plasticity and slip system of plate-shaped crystals of Llysine monohydrochloridedihydrate, Pharm. Res. 19 (2002) 491-496; DOI: 0724-8741/02/0400-0491/0.
    Open DOISearch in Google Scholar
  96. 96. C. M. Reddy, K. A. Padmanabhan and G. R. Desiraju, Structure-property correlations in bending and brittle organic crystals, Cryst. Growth Des. 6 (2006) 2720-2731; DOI: 10.1021/cg060398w.
    Open DOISearch in Google Scholar
  97. 97. M. S. R. N. Kiran, S. Varughese, C. M. Reddy, U. Ramamurty and G. R. Desiraju, Mechanical anisotropy in crystalline saccharin: nanoindentation studies, Cryst. Growth Des. 10 (2010) 4650-4655; DOI: 10.1021/cg1009362.
    Open DOISearch in Google Scholar
  98. 98. M. Egart, B. Janković, N. Lah, I. Ilić and S. Srčič, Nanomechanical properties of selected single pharmaceutical crystals as a predictor of their bulk behaviour, Pharm. Res. 32 (2015) 469-481; DOI: 10.1007/s11095-014-1475-3.
    Open DOISearch in Google Scholar
  99. 99. R. J. Roberts and R. C. Rowe, The compaction of pharmaceutical and other model materials: a pragmatic approach, Chem. Eng. Sci. 42 (1987) 903-911; DOI: 009-2509/87.
    Search in Google Scholar
  100. 100. M. K. Mishra, U. Ramamurty and G. R. Desiraju, Hardness alternation in α,ω-alkanedicarboxylic acids, Chem. Asian J. 10 (2015) 2176-2181; DOI: 10.1002/asia.201500322.
    Open DOISearch in Google Scholar
  101. 101. M. K. Mishra, S. Varughese, U. Ramamurty, and G. R. Desiraju, Odd-even effect in the elastic moduli of α,ω-alkanedicarboxylic acids, J. Am. Chem. Soc. 135 (2013) 8121-8124; DOI: 10.1021/ ja402290hl.
    Open DOISearch in Google Scholar
  102. 102. P. Sanphui, M. K. Mishra, U. Ramamurty and G. R. Desiraju, Tuning mechanical properties of pharmaceutical crystals with multicomponent crystals: voriconazole as a case study, Mol. Pharmaceutics 12 (2015) 889-897; DOI: 10.1021/mp500719t.
    Open DOISearch in Google Scholar
  103. 103. S. Chen, A. Y. Sheikh and R. Ho, Evaluation of effects of pharmaceutical processing on structural disorders of active pharmaceutical ingredient crystals using nanoindentation and highresolution total scattering pair distribution function analysis, J. Pharm. Sci. 103 (2014) 3879-3890; DOI: 10.1002/jps.24178.
    Open DOISearch in Google Scholar
  104. 104. M. K. Mishra, P. Sanphui, U. Ramamurty and G. R. Desiraju, Solubility-hardness correlation in molecular crystals: curcumin and sulfathiazole polymorphs, Cryst. Growth Des. 14 (2014) 3054-3061; DOI: 10.1021/cg500305.
    Search in Google Scholar
  105. 105. I. Azuri, E. Meirzadeh, D. Ehre, S. R. Cohen, A. M. Rappe, M. Lahav, I. Lubomirsky and L. Kronik, Unusually large Young’s moduli of amino acid molecular crystals, Angew. Chem. Int. Ed. 54 (2015) 1-6; DOI: 10.1002/anie.201505813.
    Open DOISearch in Google Scholar
  106. 106. B. A. Zakharov, B. A. Kolesov and E. V. Boldyreva, Effect of pressure on crystalline L- and DLserine: revisited by a combined single-crystal X-ray diffraction at a laboratory source and polarized Raman spectroscopy study, Acta Cryst. B68 (2012) 275-286; DOI: 10.1107/s0108768112015960.
    Open DOISearch in Google Scholar
  107. 107. C. Murli, S. M. Sharma, S. Karmakar and S. K. Sikka, α-glycine under high pressures: a Raman scattering study, Physica B339 (2003) 23-30; DOI: 10.1016/S0921-4526(03)00446-0.
    Open DOISearch in Google Scholar
  108. 108. S. Zugner, K. Marquardt and I. Zimmerman, Influence of nanomechanical crystal properties on the comminution process of particulate solids in spiral jet mills, Eur. J. Biopharm. Pharm. 62 (2006) 194-201; DOI: 10.1016/j.ejpb.2005.08.002.
    Open DOISearch in Google Scholar
  109. 109. O. Vegt, H. Vromans, J. Toonder and K. Voort Maarschalk, Influence of flaws and crystal properties on particle fracture in a jet mill, Powder Technol. 191 (2009) 72-77; DOI: 10.1016/j.powtec. 2008.09.014.
    Search in Google Scholar
  110. 110. L. Vogel and W. Peukert, Breakage behaviour of different materials-construction of a master curve for the breakage probability, Powder Technol. 129 (2003) 101-110; DOI: 10.1016/S0032-5910(02)00217-6.
    Open DOISearch in Google Scholar
  111. 111. L. Vogel and W. Peukert, From single particle impact behavior to modeling of impact mills, Chem. Engin. Sci. 60 (2005) 5164-5176; DOI: 10.1016/j.ces.2005.03.064.
    Open DOISearch in Google Scholar
  112. 112. B. Govedarica, I. Ilić, R. Šibanc, R. Dreu and S. Srčič, The use of single particle mechanical properties for predicting the compressibility of pharmaceutical materials, Powder Technol. 225 (2012) 43-51; DOI: 10.1016/j.powtec.2012.03.030.
    Open DOISearch in Google Scholar
  113. 113. P. P. Bag, M. Chen, C. C. Sun and C. M. Reddy, Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound, Cryst. Eng. Comm. 14 (2012) 3865-3867; DOI: 10.1039/c2ce25100k.
    Open DOISearch in Google Scholar
  114. 114. S. Chattoraj, L. Shi, M. Chen, A. Alhalaweh, S. Velaga and C. C. Sun, Origin of deteriorated crystal plasticity and compaction properties of a 1:1 cocrystal between piroxicam and saccharin, Cryst. Growth Des. 14 (2014) 3864-3874; DOI: 10.1021/cg500388s.
    Open DOISearch in Google Scholar
  115. 115. G. R. Krishna, L. Shi, P. P. Bag, C. C. Sun and C. M. Reddy, Correlation among crystal structure, mechanical behavior, and tabletability in the co-crystals of vanillin isomers, Cryst. Growth Des. 15 (2015) 1827-1832; DOI: 10.1021/cg5018642.
    Open DOISearch in Google Scholar
DOI: https://doi.org/10.1515/acph-2016-0032 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
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Language: English
Page range: 303 - 330
Accepted on: Jan 11, 2016
Published on: Jun 29, 2016
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Keywords:
instrumented nanoindentation,
mechanical properties,
Young’s modulus,
indentation hardness,
fracture toughness,
crystalline active ingredients and excipients
Related subjects:
Pharmacy,
Pharmacy, other

© 2016 Mateja Egart, Biljana Janković, Stane Srčič, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 66 (2016): Issue 3 (September 2016)
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