Skip to main content
Have a personal or library account? Click to login
PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation Cover

PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation

By:   
Open Access
|Jun 2016

References

  1. 1. J. K. Slack-Davis, K. H. Martin, R. W. Tilghman, M. Iwanicki, E. J. Ung, C. Autry, M. J. Luzzio, B. Cooper, J. C. Kath, W. G. Roberts and J. T. Parsons, Cellular characterization of a novel focal adhesion kinase inhibitor, J. Biol. Chem. 282 (2007) 14845-14852; DOI: 10.1074/jbc.M606695200.
  2. 2. M. J. van Nimwegen and B. van der Water, Focal adhesion kinase: A potential target in cancer therapy, Biochem. Pharmacol. 73 (2007) 597-609; DOI: 10.1016/j.bcp.2006.08.011.
  3. 3. J. D. Hood and D. A. Cheresh, Role of integrins in cell invasion and migration, Nat. Rev. Cancer 2 (2002) 91-100; DOI: 10.1038/nrc727.
  4. 4. T. Miyazaki, H. Kato, M. Nakajima, M. Sohda, Y. Fukai, N. Masuda, R. Manda, M. Fukuchi, K. Tsukada and H. Kuwano, FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma, Br. J. Cancer 89 (2003) 140-145; DOI: 10.1038/sj.bjc.6601050.
  5. 5. J. T. Parsons, J. Slack-Davis, R. Tilghman and W. G. Roberts, Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic intervention, Clin. Cancer Res. 14 (2008) 627-632; DOI: 10.1158/1078-0432.CCR-07-2220.
  6. 6. J. M. Stiles, R. K. Rowntree, C. Amaya, D. Diaz, V. Kokta, D. C. Mitchell and A. B. Brad, Gene expression analysis reveals marked differences in the transcriptome of infantile hemangioma endothelial cells compared to normal dermal microvascular endothelial cells, Vasc. Cell 5 (2013) 1-12; DOI: 10.1186/2045-824X-5-6.
  7. 7. L. V. Owens, L. Xu, G. A. Dent, X. Yang, G. C. Sturge, R. J. Craven and W. G. Cance, Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer, Ann. Surg. Oncol. 3 (1996) 100-105; DOI: 10.1007/BF02409059.
  8. 8. D. D. Schlaepfer, C. R. Hauck and D. J. Sieg, Signaling through focal adhesion kinase, Prog. Biophys. Mol. Biol. 71 (1999) 435-478; DOI: 10.1016/S0079-6107(98)00052-2.
  9. 9. L. A. Cohen and J. L. Guan, Mechanisms of focal adhesion kinase regulation, Curr. Cancer Drug Tar. 5 (2005) 629-643; DOI: 10.2174/156800905774932798.
  10. 10. P. Mabeta and M. S. Pepper, Inhibition of hemangioma development in a syngeneic mouse model correlates with Bcl-2 suppression and the inhibition of Akt kinase activity, Angiogenesis 15 (2012) 131-139; DOI: 10.10007/s10456-011-9248-7.
  11. 11. H. P. Gerber, A. McMurtrey, J. Kowalski, M. Yan, B. A. Keyt, V. Dixit and N. Ferrara, Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3’-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation, J. Biol. Chem. 273 (1998) 30336-30343; DOI: 10.1074/jbc.273.46.30336.
  12. 12. K. T. Sabapathy, M. S. Pepper, F. Kiefer, U. Möhle-Steinlein, F. Tacchini-Cottier, I. Fetka, G. Breier, W. Risau, P. Carmeliet, R. Montesano and E. F.Wagner, Polyoma middle T-induced vascular tumor formation: the role of the plasminogen activator/plasmin system, J. Cell Biol. 137 (1997) 953-963; DOI: 10.1083/jcb.137.4.953.
  13. 13. P. Mabeta and M. S. Pepper, Altered expression of platelet factor 4 and basic fibroblast growth factor correlates with the inhibition of tumor growth in mice, Biomed. Pharmacol. 69 (2015) 186-190; DOI: 10.1016/j.biopha.2014.11.018.
  14. 14. M. A. Cabrita, L. M. Jones, J. L. Quizi, L. A. Sabourin, B. C. McKay and C. L. Addison, Focal adhesion kinase inhibitors are potent anti-angiogenic agents, Mol. Oncol. 5 (2011) 517-526; DOI: 10.1016/ jmolonc.2011.10.004.
  15. 15. S. Hiscox, P. Barnfather, E. Hayes, P. Bramble, J. Christensen, R. I. Nicholson and P. Barrett-Lee, Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells, Breast Cancer Res. Treat. 125 (2011) 659-669; DOI: 10.1007/s10549-010-0857-4.
  16. 16. P. W. Bryant, Q. Zheng and K. M. Pumiglia, Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells, Biol. Open 15 (2012) 723-730; DOI: 10.1242/ bio.20121008.
  17. 17. L. Portt, G. Norman, C. Clapp, M. Greenwood and M. T. Greenwood, Anti-apoptosis and cell survival: A review, Biochim. Biophys. Acta 1813 (2011) 238-259; DOI: 10.1016/j.bbamcr.2010.10.010.
  18. 18. X. Zhao and J. L. Guan, Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis, Adv. Drug Deliver. Rev. 63 (2011) 610-615; DOI: 10.1016/j.addr.2010.11.001.
  19. 19. S. K. Mitra, D. A. Hanson and D. D. Schlaepfer. Focal adhesion kinase: in command and control of cell motility, Nat. Rev. Mol. Cell Biol. 6 (2005) 56-68; DOI: 10.1038/nrm1549.
  20. 20. B. Tavora, S. Batista, L. Reynolds, S. Jadeja, S. Robinson, V. Kostourou, I. Hart, M. Fruttiger, M. Parsons and K. M. Hodivala-Dilke, Endothelial FAK is required for tumour angiogenesis, EMBO Mol. Med. 2 (2010) 516-528; DOI: 10.1002/emmm.201000106.
  21. 21. L. H. Xu, X. Yang, C. A. Bradham, D. A. Brenner, J. A. S. Baldwin, R. J. Craven and W. G. Cance, The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells, J. Biol. Chem. 275 (2000) 30597-30604; DOI: 10.1074/jbc. M910027199.
  22. 22. C. Wiza, E. B. M. Nascimento and D. M. Ouwens, Role of PRAS40 in Akt and mTOR signaling in health and disease, Am. J. Physiol. Endocrinol. Metab. 302 (2012) E1453-E1460; DOI: 10.1152/ajpendo.00660.2011.
  23. 23. H. Wang, Q. Zhang, Q. Wen, Y. Zheng, L. Philip, H. Jiang, J. Lin and W. Zheng, Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of P13k/Akt signaling pathway, Cell Signal. 24 (2012) 17-24; DOI: 10.1016/j.cellsig.2011.08.010.
  24. 24. I. Ruvinsky, N. Sharon, T. Lerer, H. Cohen, M. Stolovich-Rain, T. Nir, Y. Dor, P. Zisman and O. Meyuhas, Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis, Genes Dev. 19 (2005) 2199-2211; DOI: 10.1101/gad.351605.
  25. 25. B. Gan, Y. Yoo and J. Guan, Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of S6 kinase activation and cell growth, J. Biol. Chem. 281 (2006) 37321-37329; DOI: 10.1074/jbc.M605241200.
  26. 26. A. Porras and C. Guerrero, Role of p38α in apoptosis: Implication in cancer development and therapy, Atlas Genet. Cytogenet. Oncol. Haematol. 15 (2011) 316-326; DOI: 10.4267/2042/44993.
DOI: https://doi.org/10.1515/acph-2016-0031 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 399 - 410
Accepted on: Jan 11, 2016
Published on: Jun 29, 2016
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Related subjects:

© 2016 Peace Mabeta, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.