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Facile heterocyclic synthesis and antimicrobial activity of polysubstituted and condensed pyrazolopyranopyrimidine and pyrazolopyranotriazine derivatives Cover

Facile heterocyclic synthesis and antimicrobial activity of polysubstituted and condensed pyrazolopyranopyrimidine and pyrazolopyranotriazine derivatives

Open Access
|Dec 2015

References

  1. 1. A. B. A. El-Gazzar and H. N. Hafez, Synthesis of 4-substituted pyrido[2,3-d]pyrimidin-4(1H)-one as analgesic and anti-inflammatory agents, Bioorg. Med. Chem. Lett. 19 (2009) 3392-3397; DOI: 10.1016/j.bmcl.2009.05.044.
  2. 2. F . M. A. El-Taweel, M. A. Sofan, M. A. Mashaly, M. A. Hanna and A. A. Elagamey, Synthesis of some new pyranoquinoline, pyridine and pyrone derivatives, Pharmazie 45 (1990) 671-673; DOI: 10.1002/chin.199149187.
  3. 3. A. M. El-Agrody, M. S. Abd El-Latif, N. A. El- Hady, A. H. Fakery and A. H. Bedair, Heteroaromatization with 4-hydroxycoumarin Part II: Synthesis of some new pyrano[2,3-d]-pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and pyrimido[1,6-b][1,2,4]triazine derivatives, Molecules 6 (2001) 519-527; DOI: 10.3390/60600519.
  4. 4. A. H. Bedair, N. A. El-Haddy, M. S. Abd El-Latif, A. H. Fakery and A. M. El-Agrody, 4- Hydroxycoumarin in heterocyclic synthesis. Part III: Synthesis of some new pyrano[2,3-d][1,2,4]triazolo[1,5- c]pyrimidine and pyrimido[1,6-b][1,2,4]triazine derivatives, Farmaco 55 (2000) 708-714; DOI: 10.1016/S0014-827X(00)00097-5.
  5. 5. A. M. El-Agrody, M. H. El-Hakim, M. S. Abd El-Latif, A. H. Fakery, E. M. El-sayed and K. A. El- Ghareab, Synthesis of pyrano[2,3-d]pyrimidine and pyrano[3,2-e][1,2,4]triazolo[2,3-c] pyrimidine derivatives with promising antibacterial activities, Acta Pharm. 50 (2000) 111-120.
  6. 6. A. G. Martinez and L. J. Marco, Friedlander reaction on 2-amino-3-cyano-4H-pyrans, synthesis of derivatives of 4H-pyran[2,3-b]quinoline, new tacrine analogues, Bioorg. Med. Chem. Lett. 7 (1997) 3165-3170; DOI: 10.1016/S0960-894X(97)10165-2.
  7. 7. F . Eiden and F. Denk, Synthesis and CNS activity of pyrane derivatives: 6,8-dioxabicyclo(3,2,1) octanes, Arch. Pharm. (Weinheim) 324 (1991) 353-354.
  8. 8. C. P. Dell and C. W. Smith, Antiproliferative derivatives of 4H-naphtho[1,2-b]pyran and process for their preparation, Eur. Pat. 537, 94, 9 21 Apr 1993; ref. Chem. Abstr. 119 (1993) 139102d.
  9. 9. F . M. Abdelrazek, P. Metz, N. H. Metwally and S. F. El-Mahrouky, Synthesis and molluscicidal activity of new cinnoline and pyrano[2,3-c]pyrazole derivatives, Arch. Pharm. Chem. Life Sci. 339 (2006) 456-460.
  10. 10. G. Bianchi and A. Tava, Synthesis of (2R)(+)-2,3-dihydro-2,6-dimethyl-4H-pyran-4-one, a homologue of pheromones of a species in the hepialidae family, Agr. Biol. Chem. 51 (1987) 2001-2002; DOI: 10.1271/bbb1961.51.2001.
  11. 11. K. Noda, A. Nakagawa, Y. Nakajima and H. Ide, Pyrido[2,3-d]-s-triazolo[4,3-c]pyrimidine derivatives, Japan Kokai 7785, 194, 15 Jul 1977; ref. Chem. Abstr. 88 (1978) P50908q.
  12. 12. H. N. Hafez, H. A. S. Abbas and A. B. A. El-Gazzar, Synthesis and evaluation of analgesic, antiinflammatory and ulcerogenic activities of some triazolo- and 2-pyrazolyl-pyrido[2,3-d]-pyrimidines, Acta. Pharm. 58 (2008) 359-378; DOI: 10.2478/v10007-008-0024-1.
  13. 13. A. B. A. El-Gazzar, H. A. R. Hossein and H. N. Hafez, Synthesis and biological evaluation of thieno[2,3-d]pyrimidines derivatives as anti-inflammatory, analgesic and ulcerogenic activity, Acta. Pharm. 57 (2007) 395-411; DOI: 10.2478/v10007-007-0032-6.
  14. 14. A. B. A. El-Gazzar, H. N. Hafez and G. M. Nawwar, New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b] quinolines, Eur. Med. Chem. 44 (2009) 1427-1436; DOI: 10.1016/j.ejmech. 2008.09.030.
  15. 15. L . P. Prikazchikova, B. M. Khutova, I. F. Vladimirtsev, I. V. Boldyrev and N. I. Zhuravskaya, stimulating activity of mono- and diketone pyrimidine derivatives, Fiziol. Akt. Veshchestva 7 (1975) 84-87; ref. Chem. Abstr. 83 (1975) 127346m.
  16. 16. D . J. Brown, Pyrimidines and Their Benzo Derivatives, in Comprehensive Heterocyclic Chemistry (Eds. A. R. Katritzky and C. W. Rees), Vol. 3, Pergamon Press, Oxford 1984, p. 443.
  17. 17. S. M. Yu, S. C. Kuo, L. J. Huang, S. S. M. Sun, T. F. Huang and C. M. Teng, Vasorelaxation of rat thoracic aorta caused by two Ca2+-channel blockers, HA-22 and HA-23, J. Pharm. Pharmacol. 44 (1992) 667-671; DOI: 10.1111/j.2042-7158.1992.tb05491.x.
  18. 18. D . Catarzi, L. Cecchi, V. Colotta, G. Filacchioni, C. Martini, P. Tacchi and A. Lucacchini, Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c]pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1Hpyrazolo[ 3,4-b]quinolin-4-ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines, J. Med. Chem. 38 (1995) 1330-1336.
  19. 19. N . Foloppe, L. M. Fisher, R. Howes, A. Potter, A. G. S. Robertson and A. E. Surgenor, Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening, Bioorg. Med. Chem. 14 (14) (2006) 4792-4802; DOI: 10.1016/j.bmc.2006.03.021.
  20. 20. H. M. Al-Matar, K. D. Khalil, A. Y. Adam and M. H. Elnagdi, Green one pot solvent-free synthesis of pyrano[2,3-c]pyrazoles and pyrazolo[1,5-a]pyrimidines, Molecules 15 (2010) 6619-6629; DOI: 10.3390/molecules15096619.
  21. 21. S. R. Jain and A. Kar, The antibacterial activity of some essential oils and their combination, Planta Med. 20 (1971) 118-123; DOI: 10.1055/s-0028-109967.
  22. 22. H. Naeimi, Z. S. Nazifi, S. M. Amininezhad and M. Amouheidari, Synthesis, characterization and in vitro antimicrobial activity of some new Schiff bases and their complexes, J. Antibiot. 66 (2013) 687-689; DOI: 10.1038/ja.2013.73.
  23. 23. M . B. Madhusudana Reddy, V. P. Jayashankara and M. A. Pasha, Glycine-catalyzed efficient synthesis of pyranopyrazoles via one-pot multicomponent reaction, Synth. Commun. 40 (2010) 2930-2934; DOI: 10.1080/00397910903340686.
  24. 24. D . Thomae, G. Kirsch and P. Seck, Synthesis of selenophene analogues of the tacrine series: comparison of classical route and microwave irradiation, Synthesis 10 (2008) 1600-1606; DOI: 10.1055/s-2008-1067001.
  25. 25. N . Galic, B. Peric, B. Kojic-Prodic and Z. Cimerman, Structural and spectroscopic characteristics of aroylhydrazones derived from nicotinic acid hydrazide, J. Mol. Struct. 559 (2001) 187-194; DOI: 10.10.1016/S0022-2860(00)00703-1.
  26. 26. V. Klimesova, L. Zahajska, K. Waisser, J. Kaustova and U. Mollmann, Synthesis and antimycobacterial activity of 1, 2, 4-triazole 3-benzylsulfanyl derivatives, Farmaco 59 (2004) 279-288; DOI: 10.1016/j.farmac.2004.01.006.
DOI: https://doi.org/10.1515/acph-2015-0037 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 399 - 412
Accepted on: Dec 22, 2014
Published on: Dec 17, 2015
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
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© 2015 Hend N. Hafez, Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.