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Preparation and investigation of mefenamic acid – polyethylene glycol – sucrose ester solid dispersions Cover

Preparation and investigation of mefenamic acid – polyethylene glycol – sucrose ester solid dispersions

Acta Pharmaceutica
Volume 65 (2015): Issue 4 (December 2015)
By: ,  ,  ,  ,  ,   and    
Open Access
|Dec 2015
References

References

  1. 1. S. C. Sweetman (Ed.), Martindale: The Complete Drug Reference, 36th ed., Pharmaceutical Press, London 2009, p. 80.
    Search in Google Scholar
  2. 2. M. Batt, Non-coeliac flat jejunal mucosa, Gut 30 (1989) 67-68.
    Open DOISearch in Google Scholar
  3. 3. T. Hamaguchi, D. Shinkuma, Y. Yamanaka and N. Mizuno, Bioavailability of mefenamic acid: influence of food and water intake, J. Pharm. Sci. 75 (1986) 891-893.
    Search in Google Scholar
  4. 4. J. L. Wallace, Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy, World J. Gastroenterol. 19 (2013) 1861-1876; DOI: 10.3748/wjg.v19.i12.1861.
    Open DOISearch in Google Scholar
  5. 5. D. V. Derle, M. Bele and N. Kasliwal, In vitro and in vivo evaluation of mefenamic acid and its complexes with b-cyclodextrin and HP-b-cyclodextrin, Asian J. Pharm. 2 (2008) 30-34; DOI: 10. 4103/0973-8398.41562.
    Open DOISearch in Google Scholar
  6. 6. G. L. Amidon, H. Lennernas, V. P. Shah and J. R. Crison, A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm. Res. 12 (1995) 413-420.
    Search in Google Scholar
  7. 7. D. Mudit, Y. Bhardwaj, P. K. Keshavarao and P. Selvam, Enhancing solubility and dissolution of mefenamic acid by freeze drying using b-cyclodextrin, Int. Res. J. Pharm. 2 (2011) 146-150; DOI: http://dx.doi.org/10.1590/S1984-82502011000400011.
    Open DOISearch in Google Scholar
  8. 8. U. Domanska, A. Pelczara and A. Pobudowska, Effect of 2-hydroxypropyl-b-cyclodextrin on solubility of sparingly soluble drug derivatives of anthranilic acid, Int. J. Mol. Sci. 12 (2011) 2383-2394; DOI: 10.3390/ijms12042383.
    Open DOISearch in Google Scholar
  9. 9. I. Fülöp, Á. Gyéresi and Ș. Hobai, Characterisation of the interaction between fenamates and hydroxy- propyl-b-cyclodextrin, Bull. Med. Sci. 83 (2010) 58-62.
    Search in Google Scholar
  10. 10. K. R. Rao, M. V. Nagabhushanam and K. P. Chowdary, In vitro dissolution studies on solid dispersions of mefenamic acid, Indian J. Pharm. Sci. 73 (2011) 243-247; DOI: 10.4103/0250-474X.91575.
    Open DOISearch in Google Scholar
  11. 11. G. Owusu-Ababio, N. K. Ebube, R. Reams and M. Habib, Comparative dissolution studies for mefenamic acid-polyethylene glycol solid dispersion systems and tablets, Pharm. Dev. Technol. 3 (1998) 405-412; DOI: 10.3109/10837459809009868.
    Open DOISearch in Google Scholar
  12. 12. A. Dahan A and J. M. Miller, The solubility-permeability interplay and its implications in formulation design and development for poorly soluble drugs, AAPS J. 14 (2012) 244-251; DOI: 10.1208/ s12248-012-9337-6.
    Open DOISearch in Google Scholar
  13. 13. A. Beig, R. Agbaria and A. Dahan, Oral delivery of lipophilic drugs: The tradeoff between solubility increase and permeability decrease when using cyclodextrin-based formulations, Plos One 8 (2013) e68237; DOI: 10.1371/journal.pone.0068237.
    Open DOISearch in Google Scholar
  14. 14. G. E. Amidon, W. I. Higuchi and N. F. Ho, Theoretical and experimental studies of transport of micelle-solubilized solutes, J. Pharm. Sci. 71 (1982) 77-84.
    Open DOISearch in Google Scholar
  15. 15. J. M. Miller, A. Beig, R. A. Carr, G. K. Webster and A. Dahan, The solubility-permeability interplay when using cosolvents for solubilization: revising the way we use solubility-enabling formulations, Mol. Pharm. 9 (2012) 581-590; DOI: 10.1021/mp200460u.
    Open DOISearch in Google Scholar
  16. 16. A. Beiq, J. M. Miller and A. Dahan, Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: the effect of PEG-400 on carbamazepine absorption, Eur. J. Pharm. Biopharm. 81 (2012) 386-391; DOI: 10.1016/j.ejpb.2012.02.012.
    Open DOISearch in Google Scholar
  17. 17. L. Kiss, E. Hellinger, A. M. Pilbat, A. Kittel, Z. Török, A. Füredi, G. Szakács, S. Veszelka, P. Sipos, B. Ózsvári, L. G. Puskás, M. Vastag, P. Szabó-Révész and M. A. Deli, Sucrose esters increase drug penetration, but do not inhibit P-glycoprotein in Caco-2 intestinal epithelial cells, J. Pharm. Sci. 103 (2014) 3107-3119; DOI: 10.1002/jps.24085.
    Open DOISearch in Google Scholar
  18. 18. A. Szűts and P. Szabó-Révész, Sucrose esters as natural surfactants in drug delivery systems - a mini-review, Int. J. Pharm. 433 (2012) 1-9; DOI: 10.1016/j.ijpharm.2012.04.076.
    Open DOISearch in Google Scholar
  19. 19. T. Hladon, J. Pawlaczyk and B. Szafran, Stability of mefenamic acid in the inclusion complex with b-cyclodextrin in the solid phase, J. Incl. Phenom. Macrocycl. Chem. 35 (1999) 497-506; DOI: 10.1023/ A:1008048612736.
    Open DOISearch in Google Scholar
  20. 20. Ryoto Sugar Ester Technical Information, Ryoto Sugar Ester (Food grade)/ Surfhope™ SE Pharma, Mitsubishi-Kagaku Foods Corporation; http://www.mfc.co.jp/english; last access date May 25, 2015.
    Search in Google Scholar
  21. 21. A. Szűts, E. Pallagi, G. Regdon, Jr., Z. Aigner and P. Szabó-Révész, Study of thermal behaviour of sugar esters, Int. J. Pharm. 336 (2007) 199-207; DOI: 10.1016/j.ijpharm.2006.11.053.
    Open DOISearch in Google Scholar
  22. 22. A. Szűts, Zs. Makai, R. Rajkó and P. Szabó-Révész, Study of the effects of drugs on the structures of sucrose esters and the effects of solid-state interactions on drug release, J. Pharm. Biomed. Anal. 48 (2008) 1136-1142; DOI: 10.1016/j.jpba.2008.08.028.
    Open DOISearch in Google Scholar
  23. 23. European Pharmacopoeia 8th ed., Council of Europe, Strasbourg 2013, pp. 288-295.
    Search in Google Scholar
  24. 24. Y. Zhang, M. Huo, J. Zhou, A. Zou, W. Li, C. Yao and S. Xie, DDSolver: an add-in program for modeling and comparison of drug dissolution profiles, AAPS J. 12 (2010) 263-271; DOI: 10.1208/ s12248-010-9185-1.
    Search in Google Scholar
  25. 25. P. Costa and J. M. Sousa Lobo, Modeling and comparison of dissolution profiles, Eur. J. Pharm. Sci. 13 (2001) 123-133; DOI: 10.1016/S0928-0987(01)00095-1.
    Open DOISearch in Google Scholar
  26. 26. I. Fülöp, Á. Gyéresi, M. A. Deli, L. Kiss, M. D. Croitoru, P. Szabó-Révész and Z. Aigner, Ternary solid dispersions of oxicams: Dissolution and permeability study, Farmacia 63 (2015) 286-295.
    Search in Google Scholar
  27. 27. M. Dixit, A. Kini and P. K. Kulkarni, Enhancing the dissolution of polymorphs I and II of mefenamic acid by spray drying, Turk. J. Pharm. Sci. 9 (2012) 13-26.
    Search in Google Scholar
  28. 28. S. Romero, B. Escalera and P. Bustamante, Solubility behavior of polymorphs I and II of mefenamic acid in solvent mixtures, Int. J. Pharm. 178 (1999) 193-202.
    Open DOISearch in Google Scholar
  29. 29. S. G. Vijaya Kumar and D. N. Mishra, Preparation, characterization and in vitro dissolution studies of solid dispersion of meloxicam with PEG 6000, Yakugaku Zasshi (J. Pharm. Sci. Japan) 126 (2006) 657-664.
    Open DOISearch in Google Scholar
  30. 30. H. Lokhandwala, A. Deshpande and S. Deshpande, Kinetic modelling and dissolution profiles comparison: an overview, Int. J. Pharm. Biol. Sci. 4 (2013) 728-737.
    Search in Google Scholar
DOI: https://doi.org/10.1515/acph-2015-0035 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
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Language: English
Page range: 453 - 462
Accepted on: Jul 14, 2015
Published on: Dec 17, 2015
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Keywords:
mefenamic acid,
sucrose esters,
PEG 6000,
solid dispersion,
Caco-2 cells
Related subjects:
Pharmacy,
Pharmacy, other

© 2015 Ibolya Fülöp, Árpád Gyéresi, Lóránd Kiss, Mária A. Deli, Mircea Dumitru Croitoru, Piroska Szabó-Révész, Zoltán Aigner, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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