Skip to main content
Have a personal or library account? Click to login
Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization Cover

Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization

Acta Pharmaceutica
Volume 65 (2015): Issue 3 (September 2015)
By: ,   and    
Open Access
|Sep 2015
References

References

  1. 1. R. K. Maheshwari, A. K. Singh, J. Gaddipati and R. C. Srimal, Multiple biological activities of curcumin: a short review,(2006) 2081–2087; DOI: 10.1016/j.lfs.2005.12.007.
    Open DOISearch in Google Scholar
  2. 2. R. Sharma, C. Ireson, R. Verschoyle, K. Hill, M. Williams, C. Leuratti, M. Manson, L. Marnett and W. Steward, Effects of dietary curcumin on glutathione-S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels,(2001) 1452–1458.
    Search in Google Scholar
  3. 3. R. A. Sharma, S. A. Euden, S. L. Platton, D. N. Cooke, A. Shafayat, H. R. Hewitt, T. H. Marczylo, B. Morgan and D. Hemingway, Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance,(2004) 6847–6854.
    Search in Google Scholar
  4. 4. A. Paradkar, A. A. Ambike, B. K. Jadhav and K. R. Mahadik, Characterization of curcumin-PVP solid dispersion obtained by spray drying,(2004) 281–286; DOI: 10.1016/j.ijpharm.2003.11.014.
    Open DOISearch in Google Scholar
  5. 5. M. H. Leung, H. Colangelo and T. W. Kee, Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis,(2008) 5672–5675; DOI: 10.1021/la800780w.
    Open DOISearch in Google Scholar
  6. 6. T. H. Kim, H. H. Jiang, Y. S. Youn, C. W. Park, K. K. Tak, S. Lee, H. Kim and S. Y. Jon, Preparation and characterization of water-soluble albumin bound curcumin nanoparticles with improved antitumor activity,(2011) 285–591; DOI: 10.1016/j.ijpharm.2010.10.041.
    Open DOISearch in Google Scholar
  7. 7. Y. B. Pawar, H. Purohit, G. Valicherla, B. Munjal, S. V. Lale, S. Patel and A. K. Bansal, Novel lipid based oral formulation of curcumin: development and optimization by design of experiments approach,(2012) 617–623; DOI: 10.1016/j.ijpharm.2012.07.031.
    Open DOISearch in Google Scholar
  8. 8. J. Cui, B. Yu, Y. Zhao, W. Zhu, H. Li and H. Lou, Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems,(2009) 148–155; DOI: 10.1016/j.ijpharm.2008.12.009.
    Open DOISearch in Google Scholar
  9. 9. C. G. Chen, T. D. Johnston, H. Jeon, R. Gedaly, P. P. McHugh, T. G. Burke and D. Ranjan, An in vitro study of liposomal curcumin: stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B cells,(2009) 133–139; DOI: 10.1016/j.ijpharm.2008.09.009.
    Open DOISearch in Google Scholar
  10. 10. K. Maiti, K. Mukherjee, A. Gantait, B. Saha and P. K. Mukherjee, Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats,(2007) 155–163; DOI: 10.1016/j.ijpharm.
    Search in Google Scholar
  11. 11. N. K. Gupta and V. K. Dixit, Bioavailability enhancement of curcumin by complexation with phosphatidylcholine,(2011) 1987–1995; DOI: 10.1002/jps.22393.
    Open DOISearch in Google Scholar
  12. 12. J. Zhang, Q. Tang, X. Xu and N. Li, Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery,(2013) 168–174; DOI: 10.1016/j.ijpharm.2013.03.021.
    Open DOISearch in Google Scholar
  13. 13. P. Shivanand and P. Kinjal, Phytosomes: Technical revolution in phytomedicine,(2010) 627–631.
    Search in Google Scholar
  14. 14. J. Patel, R. Patel, K. Khambholja and N. Patel, An overview of phytosomes as an advanced herbal drug delivery system,(2009) 363–371.
    Search in Google Scholar
  15. 15. A. Semalty, M. Semalty, B. S. Rawat, D. Singh and M. S. Rawat, Pharmacosomes: the lipid-based new drug delivery system,(2009) 599–612; DOI: 10.1517/17425240902967607.
    Open DOISearch in Google Scholar
  16. 16
    Search in Google Scholar
  17. 17. H. I. Benza and W. L. Munyendo, A review of progress and challenges in soft gelatin capsules formulations for oral administration,(2011) 20–24.
    Search in Google Scholar
  18. 18. R. P. Gullapalli, Soft gelatin capsules (softgels),(2010) 4109–4121; DOI: 10.1002/jps.22151.
    Open DOISearch in Google Scholar
  19. 19. W. J. Jones, Softgels: consumer perceptions and market impact relative to other oral dosage forms,.(2000) 213–221.
    Search in Google Scholar
  20. 20. L. L. Schramm,, Wiley, Weinheim 2005.
    Open DOISearch in Google Scholar
  21. 21. M. Brewster, R. Vandecruys, J. Peeters, P. Neeskens and G. Verreck, Comparative interaction of 2-hydroxypropyl cyclodextrin and sulfobutylether-cyclodextrin with itraconazole: phase-solubility behavior and stabilization of supersaturated drug solutions,(2008) 94–103; DOI: 10.1016/j.ejps.2008.02.007.
    Open DOISearch in Google Scholar
  22. 22. M. S. Freag, Y. S. Elnaggar and O. Y. Abdallah, Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: optimization and ex vivo permeation,(2013) 2385–2397; DOI: 10.2147/IJN.S45231.
    Open DOISearch in Google Scholar
  23. 23. F. Zhang, G. Y. Koh, D. P. Jeansonne, J. Hollingsworth, P. S. Russo, G. Vicente, R. W. Stout and Z. Liu, A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity,(2011) 2778–89; DOI: 10.1002/jps.22512.
    Open DOISearch in Google Scholar
  24. 24in(Ed. D. Krezhova), InTech 2011, pp. 483–450.
    Search in Google Scholar
  25. 25. Z. Hou, Y. Li, Y. Huang, C. Zhou, J. Lin, Y. Wang, F. Cui, S. Zhou, M. Jia, S. Ye and Q. Zhang, Phytosomes loaded with mitomycin C-soybean phosphatidylcholine complex developed for drug delivery,(2013) 90–101; DOI: 10.1021/mp300489p.
    Open DOISearch in Google Scholar
  26. 26. M. A. Elsheikh, Y. S. Elnaggar, E. Y. Gohar and O. Y. Abdallah, Nanoemulsion liquid preconcentrates for raloxifene hydrochloride: optimization and in vivo appraisal,(2012) 3787–3802; DOI: 10.2147/IJN.S33186.
    Open DOISearch in Google Scholar
  27. 27. X. Ren, X. Mao, L. Si, L. Cao and H. Xiong, Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration,(2008) 279–288; DOI: 10.1016/j.ejpb.2008.03.019.
    Open DOISearch in Google Scholar
  28. 28. X. Ren, X. Mao, L. Si, L. Cao and J. Qiu, Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo,(2009) 401–411; DOI: 10.1016/j.ejps.2008.11.002.
    Open DOISearch in Google Scholar
  29. 29. B. Wahlang, Y. B. Pawar and A. K. Bansal, Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model,(2011) 275–282; DOI: 10.1016/j.ejpb.2010.12.006.
    Open DOISearch in Google Scholar
  30. 30. S. A. Saraf, Applications of novel drug delivery system for herbal formulations,(2010) 680–689; DOI: 10.1016/j.fitote.2010.05.001.
    Open DOISearch in Google Scholar
DOI: https://doi.org/10.1515/acph-2015-0029 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Journal RSS Feed
Language: English
Page range: 285 - 297
Accepted on: Jun 25, 2015
Published on: Sep 30, 2015
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Keywords:
curcumin,
phospholipid,
phytosomes,
bioavailability,
lipids,
softgels
Related subjects:
Pharmacy,
Pharmacy, other

© 2015 Ahmed N. Allam, Ibrahim A. Komeil, Ossama Y. Abdallah, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 65 (2015): Issue 3 (September 2015)
Previous article
Next article