Skip to main content
Have a personal or library account? Click to login
Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes Cover

Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes

Open Access
|May 2015

References

  1. 1. D. M. Campoli-Richards, E. M. Sorkin and R. C. Heel, Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, Drugs 32 (1986) 383-424.
  2. 2. H. Ohnishi, H. Kosuzume, H. Inaba, M. Ohkura, S. Shimada and Y. Suzuki, The immunomodulatory action of inosiplex in relation to its effects in experimental viral infections, Int. J. Immunopharmacol. 5 (1983) 181-196.
  3. 3. H. Ohnishi, H. Kosuzume, H. Inaba, M. Okura, Y. Morita, H. Mochizuki and Y. Suzuki, Mechanism of host defence suppression induced by viral infection: mode of action of inosiplex as an antiviral agent, Infect. Immun. 38 (1982) 243-250.
  4. 4. K. Y. Tsang, H. H. Fudenberg and M. J. Gnagy, Restoration of immune response of aging hamsters by treatment with isoprinosine, J. Clin. Invest. 71 (1983) 1750-1755; DOI: 10.1A2/JCI110930.
  5. 5. J. Gutierrez, R. S. Issacson and B. S. Koppel, Subacute sclerosing panencephalitis: an update, Dev. Med. Child. Neurol. 52 (2010) 901-907; DOI: 10.1111/j.1469-8749.2010.03717.x.
  6. 6. C. Pedersen, E. Sandstrocm, C. S. Petersen, G. Norkrans, J. Gerstoft , A. Karlsson, K. C. Christensen, C. Hakanson, P. Pehrson, J. O. Nielsen, H. J. Jucrgensen, and Scandinavian Isoprinosine Study Group, The efficacy of inosine pranobex in preventing the acquired immunodeficiency syndrome in patients with human immunodeficiency virus infection, New Engl. J. Med. 322 (1990) 1757-1763; DOI: 10.1056/NEJM199006213222501.
  7. 7. T. Nakamura, N. Miyasaka, R. M. Pope, N. Talal and I. J. Russell, Immunomodulation by isoprinosine: effects on in vitro immune functions of lymphocytes from humans with autoimmune diseases, Clin. Exp. Immunol. 52 (1983) 67-74.
  8. 8. J. W. Hadden, E. M. Hadden and R. G. Coffey, Isoprinosine augmentation of phytohemagglutinininduced lymphocyte proliferation, Infect. Immun. 13 (1976) 382-387.
  9. 9. J. Litzman, J. Lokaj, M. Krejci, S. Pesak and G. Morgan, Isoprinosine does not protect against frequent respiratory tract infections in childhood, Eur. J. Pediatr. 158 (1999) 32-37.
  10. 10. M. Gołębiowska-Wawrzyniak, K. Markiewicz, A. Kozar, P. Derentowicz, J. Czerwińska-Kartowicz, K. Jastrzębska-Janas, J. Wacławek, Z. M. Wawrzyniak and H. Siwinska-Gołębiowska, Immunological and clinical study on the therapeutic efficacy of inosine pranobex, Pol. Merkur. Lekarski 19 (2005) 379-382.
  11. 11. P. Hersey and A. Edwards, Effect of isoprinosine on natural killer cell activity of blood mononuclear cells in vitro and in vivo, Int. J. Immunopharmacol. 6 (1984) 315-320; DOI: 10.1016/0192-0561(84)90048-1.
  12. 12. S. Milano, M. Dieli, S. Millott , M. D. Miceli, E. Maltese and E. Cillari, Effect of isoprinosine on IL-2, IFN-γ and IL-4 production in vivo and in vitro, Int. J. Immunopharmacol. 13 (1991) 1013-1018; DOI: 10.1016/0192-0561(91)90055-C.
  13. 13. S. Jiang and C. Dong, A complex issue on CD4+ T-cell subsets, Immunol. Rev. 252 (2013) 5-11; DOI: 10.1111/imr.12041.
  14. 14. S. McHugh, J. Deighton, I. Rifkin and P. Ewan, Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture, Eur. J. Immunol. 26 (1996) 1260-1265; DOI: 10.1002/eji.1830260612.
  15. 15. B. Perussia, The cytokine profile of resting and activated NK cells, Methods 9 (1996) 370-378; DOI: 10.1084/jcm.20032058.
  16. 16. M. Akdis, J. Verhagen, A. Taylor, F. Karamloo, C. Karagiannidis, R. Crameri, S. Thunberg, G. Deniz, R. Valenta, H. Fiebig, C. Kegel, R. Disch, C. B. Schmidt-Weber, K. Blaser and C. A. Akdis, Immune response in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells, J. Exp. Med. 199 (2004) 1567-1575.
  17. 17. I. Striz, E. Brabcova, L. Kolesar and A. Sekerkova, Cytokine networking of innate immunity cells: a potential target of therapy, Clin. Sci. 126 (2014) 593-612; DOI: 10.1042/CS20130497.
  18. 18. B. K. Pedersen, N. Tvede, M. Diamant, J. Gerstoft , M. Bagge Hansen, P. M. Haahr, M. Hording, M. Kappel, M. Klokker, B. Soeberg and P. Skinhoj, Effects of isoprinosine treatment of HIV-positive patients on blood mononuclear cell subsets, NK- and T-cell function, tumor necrosis factor, and interleukins 1, 2, and 6, Scand. J. Immunol. 32 (1990) 641-649.
  19. 19. M. Petrova, D. Jelev and Z. Krastev, Isoprinosine affects serum cytokine levels in healthy adults, J. Interferon Cytokine Res. 30 (2010) 223-227; DOI: 10.1089/jir.2009.0057.
  20. 20. R. Sabat, G. Grutz, K. Warszawska, S. Kirsch, E. Witte, K. Wolk and J. Geginat, Biology of interleukin-10, Cytokine Growth Factor Rev. 21 (2010) 331-344; DOI: 1016/j.cytogfr.2010.09.002.
  21. 21. A. Langkjaer, B. Kristensen, B. E. Hansen, H. Schultz, L. Hegedus and C. H. Nielsen, B-cell exposure to self-antigen induces IL-10 producing B cells as well as IL-6- and TNF-α-producing B-cell subsets in healthy humans, Clin. Immunol. 145 (2012) 1-10; DOI: 10.1016/j.clim.2012.07.004.
  22. 22. M. Saraiva and A. O’Garra, The regulation of IL-10 production by immune cells, Nat. Rev. Immunol. 10 (2010) 170-181; DOI: 10.103/nri2711.
  23. 23. G. Del Prete, M. De Carli, F. Almerigogna, M. G. Giudizi, R. Biagotti and S. Romagnani, Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation an cytokine production, J. Immunol. 150 (1993) 353-360.
  24. 24. S. Gregori, K. S. Goudy and M. G. Roncarolo, The cellular and molecular mechanisms of immunosuppression by human type 1 regulatory T cells, Front. Immunol. 3 (2012), article 30; DOI: 10.3389/ fimmu.2012.00030.
  25. 25. A. A. Navarini, M. Recher, K. S. Lang, P. Georgiev, S. Meury, A. Bergthaler, L. Flatz, J. Bille, R. Landmann, B. Odermatt , H. Hengartner and R. M. Zinkernagel, Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses, PNAS 103 (2006) 15335-15539; DOI: 10.1073/pnas.0607225103.
  26. 26. W. W. Metzger and K. Sun, Immune dysfunction and bacterial coinfections following influenza, J. Immunol. 191 (2013) 2047-2052; DOI: 10.4049/jimmunol.1301152.
DOI: https://doi.org/10.1515/acph-2015-0015 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 171 - 180
Accepted on: Nov 20, 2014
Published on: May 23, 2015
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Related subjects:

© 2015 Witold Lasek, Michał Janyst, Rafał Wolny, Łukasz Zapała, Katarzyna Bocian, Nadzieja Drela, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.