Abstract
The authors are presenting a rare case of recurrent acne fulminans (AF) in man with Crohn‘s disease (CD). First attak of AF as associated disorder was observed at the age of 21 with positivity rheumatoid factor (28.0 U/ml), Creactive protein (86.7 m/l), ANA (1:160), p-ANCA (1:40) and 82 erythrocyte sedimentation rate/1 hour. The second attak of AF was observed after the 4th infliximab (5mg/kg) administration, with azathioprine (100mg/day), with positivity Epstein-Barr (EBV Real Time PCR - 1835 copies/ml). The effect of AF therapy was observed after methylprednisolone (0.5-1.0mg/kg/day) with isotretinoin (0.2-1.0mg/kg/day) administration, with continual infliximab administration.