Figure 1
NFKB1A 3′-UTR (rs696) and NFKB1 −94ATTG (rs28362491) polymorphisms. UTR, untranslated region.
Table 1
Genotype assessment of SNPs rs28362491 within NFKB1A and rs696 within NFKB1 in inflammatory disorders and glioma in the Turkish population
| Study | Controls, n (%) | Patients, n (%) | P | ||||
|---|---|---|---|---|---|---|---|
| WW | WD | DD | WW | WD | DD | ||
| Atherosclerosis [39] | |||||||
| rs28362491 | 46 (32) | 74 (51) | 25 (17) | 49 (33) | 65 (43) | 36 (24) | >0.05 |
| rs696 | 20 (14) | 82 (56) | 43 (30) | 33 (22) | 65 (43) | 52 (35) | 0.02 |
| Morbid obesity [46] | |||||||
| rs28362491 | 73 (35) | 108 (52) | 26 (13) | 92 (46.5) | 86 (43.5) | 20 (10) | 0.03 |
| Male infertility [57] | |||||||
| rs28362491 | 45 (30) | 83 (55) | 22 (15) | 59 (39) | 63 (42) | 28 (19) | 0.03 |
| rs696 | 25 (16.7) | 84 (56) | 41 (27.3) | 24 (16) | 94 (63) | 32 (21) | >0.05 |
| Hashimoto disease [61] | |||||||
| rs28362491 | 50 (27) | 113 (69) | 27 (14) | 26 (22) | 76 (63) | 18 (16) | >0.05 |
| rs696 | 26 (14) | 130 (68) | 34 (18) | 23 (19) | 74 (62) | 23 (19) | >0.05 |
| Graves disease [62] | |||||||
| rs28362491 | 50 (33.3) | 80 (53.3) | 20 (13.3) | 40 (33.3) | 63 (52.6) | 17 (14.1) | >0.05 |
| rs696 | 18 (12) | 100 (66.7) | 32 (21.3) | 14 (11.6) | 77 (64.2) | 29 (24.2) | >0.05 |
| Behçet syndrome [65] | |||||||
| rs28362491 | 50 (27) | 113 (59) | 27 (14) | 43 (48) | 38 (43) | 8 (9) | 0.003 |
| rs696 | 25 (14) | 130 (68) | 34 (18) | 18 (20) | 38 (43) | 33 (37) | 0.033 |
| Glioma [66] | |||||||
| rs28362491 | 52 (24) | 149 (66.2) | 22 (9.7) | 48 (40) | 63 (52.5) | 9 (7.5) | 0.003 |
[i] SNP, single-nucleotide polymorphism; WW, wild homozygote (ins-ins for rs28362491, AA for rs696); WD, heterozygote (ins-del for rs28362491, AG for rs696); DD, mutant homozygote (del-del for rs28362491, GG for rs696).
Table 2
Assessment of SNP alleles rs28362491 within NFKB1A and rs696 within NFKB1 in inflammatory disorders and glioma in the Turkish population
| Study | Controls Allele, n (%) | Patients Allele, n (%) | P | ||
|---|---|---|---|---|---|
| Atherosclerosis [39] | |||||
| rs28362491 | ins, 166 (57) | del, 124 (43) | ins, 163 (54) | del, 137 (46) | >0.05 |
| rs696 | A, 122 (42) | G, 168 (58) | A, 131 (44) | G, 169 (56) | >0.05 |
| Morbid obesity [46] | |||||
| rs28362491 | ins, 254 (61) | del, 160 (39) | ins, 270 (68) | del, 126 (32) | <0.05 |
| Male infertility [57] | |||||
| rs28362491 | ins, 173 (58) | del, 127 (42) | ins, 181 (60) | del, 119 (40) | >0.05 |
| rs696 | A, 142 (47) | G, 158 (53) | A, 134 (44.7) | G, 166 (55.3) | >0.05 |
| Hashimoto disease [61] | |||||
| rs28362491 | ins, 213 (56) | del, 167 (44) | ins, 128 (53) | del, 112 (47) | >0.05 |
| rs696 | A, 180 (48) | G, 198 (52) | A, 120 (50) | G, 120 (50) | >0.05 |
| Graves disease [62] | |||||
| rs28362491 | ins, 180 (60) | del, 120 (40) | ins, 143 (59.6) | del, 97 (40.4) | >0.05 |
| rs696 | A, 136 (45.3) | G, 164 (54.7) | A, 105 (43.8) | G135 (56.3) | >0.05 |
| Behçet syndrome [65] | |||||
| rs28362491 | ins, 213 (56) | del, 167 (44) | ins, 124 (70) | del, 54 (30) | 0.004 |
| rs696 | A, 180 (48) | G, 198 (52) | A, 72 (42) | G, 104 (58) | >0.05 |
| Glioma [66] | |||||
| rs28362491 | ins, 257 (57.1) | del, 193 (42.9) | ins, 159 (66.3) | del, 81 (33.7) | 0.01 |
| rs696 | A, 180 (48) | G, 198 (52) | A, 72 (42) | G, 104 (58) | >0.05 |
[i] SNP, single-nucleotide polymorphism.