Figure 1
Distribution of breast cancer subtypes by age, stage and year of diagnosis (2004–2013)
| Number of patients (%) | Subtypes | P χ2 test. | |||
|---|---|---|---|---|---|
| Luminal A-like 1,074 (46) | Luminal B-like 469 (20) | HER2 375 (16) | Triple-negative 422 (18) | ||
| Age (years) | <0.001 | ||||
| <40 | 97 (38%) | 66 (26%) | 36 (14%) | 57 (22%) | |
| 40–59 | 681 (45%) | 309 (20%) | 264 (18%) | 256 (17%) | |
| ≥60 | 296 (52%) | 94 (16%) | 75 (13%) | 109 (19%) | |
| Stage | <0.001 | ||||
| Localized | 351 (55%) | 100 (16%) | 81 (13%) | 100 (16%) | |
| Regional | 636 (42%) | 334 (22%) | 253 (17%) | 297 (19%) | |
| Distant | 72 (44%) | 31 (19%) | 38 (23%) | 24 (14%) | |
| Unknown | 15 (65%) | 4 (17%) | 3 (13%) | 1 (5%) | |
| Year of diagnosis | <0.001 | ||||
| 2004 | 35 (38%) | 22 (24%) | 19 (21%) | 15 (17%) | |
| 2005 | 32 (33%) | 20 (21%) | 20 (21%) | 24 (25%) | |
| 2006 | 76 (45%) | 35 (21%) | 20 (12%) | 38 (22%) | |
| 2007 | 93 (48%) | 37 (19%) | 24 (13%) | 38 (20%) | |
| 2008 | 128 (50%) | 35 (14%) | 40 (16%) | 53 (20%) | |
| 2009 | 91 (34%) | 56 (21%) | 60 (23%) | 57 (22%) | |
| 2010 | 109 (44%) | 55 (22%) | 48 (19%) | 38(15%) | |
| 2011 | 124 (42%) | 77 (26%) | 41 (14%) | 51 (18%) | |
| 2012 | 175 (51%) | 77 (22%) | 50 (14%) | 45 (13%) | |
| 2013 | 211 (55%) | 55 (14%) | 53 (14%) | 63 (17%) | |
Characteristics of patients at diagnosis over time (2004–2013)
| Total, n (%) | Year of diagnosis | P χ2 test for trend in proportions. | |||||
|---|---|---|---|---|---|---|---|
| 2004–2005 | 2006–2007 | 2008–2009 | 2010–2011 | 2012–2013 | |||
| Number of patients | 3,228 (100) | 530 (17) | 571 (18) | 668 (21) | 656 (20) | 803 (25) | |
| Age (years) | |||||||
| Median (IQR) | 45 (52–60) | 50 (44–58) | 51 (44–59) | 51 (45–58) | 53 (46–60) | 54 (47–61) | 0.043 Mann–Kendall trend test. |
| <40 | 349 (11) | 63 (12) | 76 (13) | 67 (10) | 72 (11) | 71 (9) | 0.02 |
| 40–59 | 2,072 (64) | 346 (65) | 358 (63) | 465 (70) | 401 (61) | 502 (62) | 0.20 |
| ≥60 | 807 (25) | 121 (23) | 137 (24) | 136 (20) | 183 (28) | 230 (29) | 0.002 |
| Stage | |||||||
| Localized | 794 (25) | 125 (24) | 132 (23) | 156 (23) | 155 (24) | 226 (28) | 0.04 |
| Regional | 2,131 (66) | 352 (66) | 390 (68) | 462 (69) | 447 (68) | 480 (60) | 0.02 |
| Distant | 235 (7) | 38 (7) | 39 (7) | 44 (7) | 49 (8) | 65 (8) | 0.39 |
| Unknown | 68 (2) | 15 (3) | 10 (2) | 6 (1) | 5 (1) | 32 (4) | 0.17 |