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Niosomes: a review of their structure, properties, methods of preparation, and medical applications Cover

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Asian Biomedicine
Volume 11 (2017): Issue 4 (August 2017)
By: Pei Ling Yeo,  Chooi Ling Lim,  Soi Moi Chye,  Anna Pick Kiong Ling and  Rhun Yian Koh  
Open Access
|Mar 2018

Figures & Tables

Figure 1

Structure of a niosome
Structure of a niosome

Figure 2

Schematic diagram of preparation of niosomes using the reverse-phase evaporation technique
Schematic diagram of preparation of niosomes using the reverse-phase evaporation technique

Figure 3

Schematic diagram of preparation of niosomes using the “bubble” method
Schematic diagram of preparation of niosomes using the “bubble” method

Figure 4

Schematic diagram of preparation of niosomes by transmembrane pH gradient (inside acidic) drug uptake process
Schematic diagram of preparation of niosomes by transmembrane pH gradient (inside acidic) drug uptake process

Drugs/compounds encapsulated in niosomes and their antibacterial or antifungal effects

Drug/compound(s)Effects compared with unencapsulated formReference(s)
ItraconazoleGreater activity against Candida albicans[100]
Diallyl disulfideGreater activity against C. albicans[101]
FluconazoleEffective against corneal fungal infections[102]
MiconazoleEffective against Trichophyton rubrum[103]
Nisin and ethylenediaminetetraacetic acidBetter effect in inhibiting Staphylococcus aureus[106]
GalliderminBetter antibacterial effects against Propionibacterium acnes and S. aureus[108]
PropolisEnhanced antimicrobial effect[110]
GatifloxacinEffective against ocular infections[111]
MoxifloxacinUsed for topical microbial infections[112]
Bismuth-ethanedithiol and tobramycinEffective against Pseudomonas aeruginosa[114]

Drugs/compounds encapsulated in niosomes and their anticancer effects

Drug/compound(s)EffectsReference(s)
DoxorubicinDecreased proliferation of sarcoma cells[26, 57]
Daunorubicin hydrochlorideDestroyed Dalton’s ascitic lymphoma cells[52]
BleomycinAccumulated in higher levels at the tumor site[52]
MethotrexateEnhanced antitumor activity against sarcoma[58]
5-FluorouracilEnhanced drug penetration in the treatment of skin cancer[59]
VincristineEnhanced antitumor activity against sarcoma[5]
TocotrienolEnhanced cytotoxicity toward breast cancer cells[61]
CurcuminEnhanced cytotoxic and apoptotic effects toward ovarian cancer cells[63]
Curcumin and doxorubicin hydrochlorideEnhanced cytotoxicity toward cervical cancer cells[64]
ArtemisininCytotoxic toward melanoma cells[68]
Tamoxifen citrateGreater cytotoxicity against breast cancer cell line[70]
MitoxantroneGreater cytotoxicity against human ovarian cancer and breast cancer cell lines[71]
CisplatinEnhanced cytotoxicity toward breast cancer cells[73]
DOI: https://doi.org/10.1515/abm-2018-0002 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
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Language: English
Page range: 301 - 314
Published on: Mar 21, 2018
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year
Keywords:
drug-delivery system,
medical applications,
methods of preparation,
niosomes,
structure
Related subjects:
Medicine,
Assistive professions, nursing,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other

© 2018 Pei Ling Yeo, Chooi Ling Lim, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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