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Niosomes: a review of their structure, properties, methods of preparation, and medical applications Cover

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Asian Biomedicine
Volume 11 (2017): Issue 4 (August 2017)
By: Pei Ling Yeo,  Chooi Ling Lim,  Soi Moi Chye,  Anna Pick Kiong Ling and  Rhun Yian Koh  
Open Access
|Mar 2018
Figures & tables

Figures & Tables

Figure 1

Structure of a niosome

Figure 2

Schematic diagram of preparation of niosomes using the reverse-phase evaporation technique

Figure 3

Schematic diagram of preparation of niosomes using the “bubble” method

Figure 4

Schematic diagram of preparation of niosomes by transmembrane pH gradient (inside acidic) drug uptake process

Drugs/compounds encapsulated in niosomes and their antibacterial or antifungal effects

Drug/compound(s)Effects compared with unencapsulated formReference(s)
ItraconazoleGreater activity against Candida albicans[100]
Diallyl disulfideGreater activity against C. albicans[101]
FluconazoleEffective against corneal fungal infections[102]
MiconazoleEffective against Trichophyton rubrum[103]
Nisin and ethylenediaminetetraacetic acidBetter effect in inhibiting Staphylococcus aureus[106]
GalliderminBetter antibacterial effects against Propionibacterium acnes and S. aureus[108]
PropolisEnhanced antimicrobial effect[110]
GatifloxacinEffective against ocular infections[111]
MoxifloxacinUsed for topical microbial infections[112]
Bismuth-ethanedithiol and tobramycinEffective against Pseudomonas aeruginosa[114]

Drugs/compounds encapsulated in niosomes and their anticancer effects

Drug/compound(s)EffectsReference(s)
DoxorubicinDecreased proliferation of sarcoma cells[26, 57]
Daunorubicin hydrochlorideDestroyed Dalton’s ascitic lymphoma cells[52]
BleomycinAccumulated in higher levels at the tumor site[52]
MethotrexateEnhanced antitumor activity against sarcoma[58]
5-FluorouracilEnhanced drug penetration in the treatment of skin cancer[59]
VincristineEnhanced antitumor activity against sarcoma[5]
TocotrienolEnhanced cytotoxicity toward breast cancer cells[61]
CurcuminEnhanced cytotoxic and apoptotic effects toward ovarian cancer cells[63]
Curcumin and doxorubicin hydrochlorideEnhanced cytotoxicity toward cervical cancer cells[64]
ArtemisininCytotoxic toward melanoma cells[68]
Tamoxifen citrateGreater cytotoxicity against breast cancer cell line[70]
MitoxantroneGreater cytotoxicity against human ovarian cancer and breast cancer cell lines[71]
CisplatinEnhanced cytotoxicity toward breast cancer cells[73]
DOI: https://doi.org/10.1515/abm-2018-0002 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
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Language: English
Page range: 301 - 314
Published on: Mar 21, 2018
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year
Keywords:
drug-delivery system,
medical applications,
methods of preparation,
niosomes,
structure
Related subjects:
Medicine,
Assistive professions, nursing,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other

© 2018 Pei Ling Yeo, Chooi Ling Lim, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 11 (2017): Issue 4 (August 2017)
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