Transcatheter Edge-to-Edge Repair in Adult Congenital Heart Disease: Anatomic Challenges, Device Adaptations, and Emerging Evidence
By: Dhaval R. Parekh
References
- Marelli AJ, Ionescu-Ittu R, Mackie AS, Guo L, Dendukuri N, Kaouache M. Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010. Circulation. 2014 Aug 26;130(9):749-756. doi: 10.1161/CIRCULATIONAHA
- Baumgartner H, De Backer J, Babu-Narayan SV, et al. 2020 ESC Guidelines for the management of adult congenital heart disease. Eur Heart J. 2021 Feb 11;42(6):563-645. doi: 10.1093/eurheartj/ehaa554
- Barry OM, Bouhout I, Kodali SK, et al. Interventions for congenital atrioventricular valve dysfunction: JACC focus seminar. J Am Coll Cardiol. 2022 Jun 7;79(22):2259-2269. doi: 10.1016/j.jacc.2021.08.083
- Abdelrehim AA, Dearani JA, Miranda WR, Connolly HM, Stephens EH. Surgical considerations for the mitral valve in congenitally corrected transposition. Ann Thorac Surg. 2024 Mar;117(3):560-566. doi: 10.1016/j.athoracsur.2023.07.009
- Alfieri O, Maisano F, De Bonis M, et al. The double-orifice technique in mitral valve repair: a simple solution for complex problems. J Thorac Cardiovasc Surg. 2001 Oct;122(4):674-681. doi: 10.1067/mtc.2001.117277
- Stone GW, Lindenfeld J, Abraham WT, et al.; COAPT Investigators. Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med. 2018 Dec 13;379(24):2307-2318. doi: 10.1056/NEJMoa1806640
- Sorajja P, Vemulapalli S, Feldman T, et al. Outcomes with transcatheter mitral valve repair in the United States: an STS/ACC TVT registry report. J Am Coll Cardiol. 2017 Nov 7;70(23):2315-2327. doi: 10.1016/j.jacc.2017.09.015
- Sorajja P, Whisenant B, Hamid N, et al.; TRILUMINATE Pivotal Investigators. Transcatheter repair for patients with tricuspid regurgitation. N Engl J Med. 2023 May 18;388(20):1833-1842. doi: 10.1056/NEJMoa2300525
- Lim DS, Kar S, Spargias K, et al.; CLASP IID Investigators. Transcatheter valve repair for patients with mitral regurgitation: 30-day results of the CLASP Study. JACC Cardiovasc Interv. 2019 Jul 22;12(14):1369-1378. doi: 10.1016/j.jcin.2019.04.034
- ACC.org [Internet]. Washington, DC: American College of Cardiology; c2026. Das TM, Alshawabkeh L, Haeffele C, Tsao AL, Vaikunth S.
“Can we clip it?”: A review of TEER in the adult congenital heart disease population . ACC Latest in Cardiology; 2025 Oct 20 [cited 2026 May 22]. Available from:https://www.acc.org/Latest-in-Cardiology/Articles/2025/10/20/11/41/Can-We-Clip-It - Perl L, Rubbio A, Bedogni F, et al. Percutaneous edge-to-edge repair of atrioventricular valves in congenital heart disease: a multicenter clinical experience. JACC Adv. 2026 Jan;5(1):102408. doi: 10.1016/j.jacadv.2025.102408
- Arnautovic JZ, Ya’Qoub L, Wajid Z, et al. Outcomes and complications of mitral and tricuspid transcatheter edge-to-edge repair. Interv Cardiol. 2024 Oct 28;19:
e20 . doi: 10.15420/icr.2024.08 - Picard F, Tadros V, Asgar AW. From tricuspid to double orifice morphology: percutaneous tricuspid regurgitation repair with the MitraClip device in congenitally corrected-transposition of great arteries. Catheter Cardiovasc Interv. 2017 Sep 1;90(3):432-436. doi: 10.1002/ccd.26834
- Blusztein D, Moore P, Qasim A, Mantri N, Mahadevan VS. Transcatheter edge-to-edge repair of systemic tricuspid valve in extracardiac Fontan circulation: first in human. JACC Case Rep. 2022 Feb 16;4(4):221-225. doi: 10.1016/j.jaccas.2021.12.02
- von Bardeleben RS, Mahoney P, Morese MA, et al. One-year outcomes with fourth-generation mitral valve transcatheter edge-to-edge repair from the EXPAND G4 Study. JACC Cardiovasc Interv. 2023 Nov 13;16(21):2600-2610. doi: 10.1016/j.jcin.2023.09.029
- Jolley MA, Sulentic A, Amin S, et al. Introduction of transcatheter edge-to-edge repair in patients with congenital heart disease at a children’s hospital. Catheter Cardiovasc Interv. 2024 Feb;103(2):326-334. doi: 10.1002/ccd.30935
- Guerin P, Jalal Z, Le Ruz R, et al. Percutaneous edge-to-edge repair for systemic atrioventricular valve regurgitation in patients with congenital heart disease: the first descriptive cohort. J Am Heart Assoc. 2022 May 17;11(9):
e025628 . doi: 10.1161/JAHA.122.025628 - Broberg CS, Van Zyl M, Bhatt AB, et al. Long-term outcomes after atrial switch operation for transposition of the great arteries. J Am Coll Cardiol. 2022 Sep 6;80(10):951-963. doi: 10.1016/j.jacc.2022.06.020
- Cuypers JAAE, Eindhoven JA, Slager MA, et al. The natural and unnatural history of the Mustard procedure: long-term outcome up to 40 years. Eur Heart J. 2014 Jul 1;35(25):1666-1674. doi: 10.1093/eurheartj/ehu102
- Koyak Z, Krings G, van der Wall EE, Hazekamp MG, de Groot JR, Mulder BJ. Late outcomes in adults with atrial switch for transposition of the great arteries according to risk factor profile at 30 years of age. Int J Cardiol Congenit Heart Dis. 2022 Nov 17;10:100396. doi: 10.1016/j.ijcchd.2022.100427
- Minaev AV, Danilov TY, Paraskevova DP, et al. Reduced ejection fraction of the systemic right ventricle and severe tricuspid regurgitation: medication or surgery? J Cardiovasc Dev Dis. 2025 Dec 8;12(12):482. doi: 10.3390/jcdd12120482
- Correa R, Walsh EP, Alexander ME, et al. Transbaffle mapping and ablation for atrial tachycardias after Mustard, Senning, or Fontan operations. J Am Heart Assoc. 2013 Sep 19;2(5):
e000325 . doi: 10.1161/JAHA.113.000325 - Iriart X, Guerin P, Jalal Z, Thambo JB. Edge to edge repair using a MitraClip for severe tricuspid valve regurgitation after a Mustard operation. Catheter Cardiovasc Interv. 2021 Jul 1;98(1):E108-E114. doi: 10.1002/ccd.29681
- Doldi P, Stolz L, Orban M, et al. Transcatheter mitral valve repair in patients with atrial functional mitral regurgitation. JACC Cardiovasc Imaging. 2022 Nov;15(11):1843-1851. doi: 10.1016/j.jcmg.2022.05.009
- Haeffele CL, Lui GK, Peng L, Chan F, Sharma RP. First described mitral clip in an adult extracardiac Fontan patient: a case report. Eur Heart J Case Rep. 2022 Dec 16;7(1):ytac479. doi: 10.1093/ehjcr/ytac479
- Alshawabkeh L, Mahmud E, Reeves R. Percutaneous mitral valve repair in adults with congenital heart disease: report of the first case-series. Catheter Cardiovasc Interv. 2021 Feb 15;97(3):542-548. doi: 10.1002/ccd.29238
DOI: https://doi.org/10.14797/mdcvj.1840 | Journal eISSN: 1947-6108
Language: English
Page range: 98 - 107
Submitted on: Apr 6, 2026
Accepted on: May 19, 2026
Published on: Jun 30, 2026
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services
Keywords:
© 2026 Dhaval R. Parekh, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.