Pulmonary Hypertension in Women

Eunwoo Park; Zeenat Safdar

doi:10.14797/mdcvj.1308

Pulmonary Hypertension in Women

Methodist DeBakey Cardiovascular Journal

Volume 20 (2024): Issue 2

By: Eunwoo Park and Zeenat Safdar

Open Access

|Mar 2024

Ruopp NF, Cockrill BA. Diagnosis and Treatment of Pulmonary Arterial Hypertension: A Review. JAMA. 2022 Apr 12;327(14):1379-1391. doi: 10.1001/jama.2022.4402. Erratum in: JAMA. 2022 Sep 6;328(9):892.
Open DOI Search in Google Scholar Back to article
Swisher JW, Weaver E. The Evolving Management and Treatment Options for Patients with Pulmonary Hypertension: Current Evidence and Challenges. Vasc Health Risk Manag. 2023 Mar 3;19:103-126. doi: 10.2147/VHRM.S321025
Open DOI Search in Google Scholar Back to article
Humbert M, Kovacs G, Hoeper MM, et al.; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2023 Jan 6;61(1):2200879. doi: 10.1183/13993003.00879-2022
Open DOI Search in Google Scholar Back to article
Franco V, Ryan JJ, McLaughlin VV. Pulmonary Hypertension in Women. Heart Fail Clin. 2019 Jan;15(1):137-145. doi: 10.1016/j.hfc.2018.08.013
Open DOI Search in Google Scholar Back to article
Cheron C, McBride SA, Antigny F, et al. Sex and gender in pulmonary arterial hypertension. Eur Respir Rev. 2021 Nov 8;30(162):200330. doi: 10.1183/16000617.0330-2020
Open DOI Search in Google Scholar Back to article
Morris H, Denver N, Gaw R, Labazi H, Mair K, MacLean MR. Sex Differences in Pulmonary Hypertension. Clin Chest Med. 2021 Mar;42(1):217-228. doi: 10.1016/j.ccm.2020.10.005
Open DOI Search in Google Scholar Back to article
Safdar Z. Pulmonary hypertension: a woman’s disease. Tex Heart Inst J. 2013;40(3):302-3. PMID: 23914026
Search in Google Scholar Back to article
McGoon MD, Benza RL, Escribano-Subias P, et al. Pulmonary arterial hypertension: epidemiology and registries. J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D51-9. doi: 10.1016/j.jacc.2013.10.023
Open DOI Search in Google Scholar Back to article
McGoon MD, Miller DP. REVEAL: a contemporary US pulmonary arterial hypertension registry. Eur Respir Rev. 2012 Mar 1;21(123):8-18. doi: 10.1183/09059180.00008211
Open DOI Search in Google Scholar Back to article
Escribano-Subias P, Blanco I, López-Meseguer M, et al.; REHAP investigators. Survival in pulmonary hypertension in Spain: insights from the Spanish registry. Eur Respir J. 2012 Sep;40(3):596-603. doi: 10.1183/09031936.00101211
Open DOI Search in Google Scholar Back to article
Skride A, Sablinskis K, Lejnieks A, Rudzitis A, Lang I. Characteristics and survival data from Latvian pulmonary hypertension registry: comparison of prospective pulmonary hypertension registries in Europe. Pulm Circ. 2018 Jul-Sep;8(3):2045894018780521. doi: 10.1177/2045894018780521
Open DOI Search in Google Scholar Back to article
Shapiro S, Traiger GL, Turner M, McGoon MD, Wason P, Barst RJ. Sex differences in the diagnosis, treatment, and outcome of patients with pulmonary arterial hypertension enrolled in the registry to evaluate early and long-term pulmonary arterial hypertension disease management. Chest. 2012 Feb;141(2):363-373. doi: 10.1378/chest.10-3114
Open DOI Search in Google Scholar Back to article
Hoeper MM, Huscher D, Ghofrani HA, et al. Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry. Int J Cardiol. 2013 Sep 30;168(2):871-80. doi: 10.1016/j.ijcard.2012.10.026
Open DOI Search in Google Scholar Back to article
Tamura Y, Kumamaru H, Satoh T, et al.; Japan PH Registry (JAPHR) Network. Effectiveness and Outcome of Pulmonary Arterial Hypertension-Specific Therapy in Japanese Patients With Pulmonary Arterial Hypertension. Circ J. 2017 Dec 25;82(1):275-282. doi: 10.1253/circj.CJ-17-0139
Open DOI Search in Google Scholar Back to article
Sithamparanathan S, Nair A, Thirugnanasothy L, et al.; National Pulmonary Hypertension Service Research Collaboration of the United Kingdom and Ireland. Survival in portopulmonary hypertension: Outcomes of the United Kingdom National Pulmonary Arterial Hypertension Registry. J Heart Lung Transplant. 2017 Jul;36(7):770-779. doi: 10.1016/j.healun.2016.12.014
Open DOI Search in Google Scholar Back to article
Peacock AJ, Murphy NF, McMurray JJ, Caballero L, Stewart S. An epidemiological study of pulmonary arterial hypertension. Eur Respir J. 2007 Jul;30(1):104-9. doi: 10.1183/09031936.00092306
Open DOI Search in Google Scholar Back to article
Humbert M, Sitbon O, Chaouat A, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation. 2010 Jul 13;122(2):156-63. doi: 10.1161/CIRCULATIONAHA.109.911818
Open DOI Search in Google Scholar Back to article
Rodriguez-Arias JJ, García-Álvarez A. Sex Differences in Pulmonary Hypertension. Front Aging. 2021 Oct 4;2:727558. doi: 10.3389/fragi.2021.727558
Open DOI Search in Google Scholar Back to article
Lahm T, Tuder RM, Petrache I. Progress in solving the sex hormone paradox in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1;307(1):L7-26. doi: 10.1152/ajplung.00337.2013
Open DOI Search in Google Scholar Back to article
Gomez-Arroyo J, Saleem SJ, Mizuno S, et al. A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects. Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L977-91. doi: 10.1152/ajplung.00362.2011
Open DOI Search in Google Scholar Back to article
Sun Y, Sangam S, Guo Q, et al. Sex Differences, Estrogen Metabolism and Signaling in the Development of Pulmonary Arterial Hypertension. Front Cardiovasc Med. 2021 Sep 10;8:719058. doi: 10.3389/fcvm.2021.719058
Open DOI Search in Google Scholar Back to article
Hester J, Ventetuolo C, Lahm T. Sex, Gender, and Sex Hormones in Pulmonary Hypertension and Right Ventricular Failure. Compr Physiol. 2019 Dec 18;10(1):125-170. doi: 10.1002/cphy.c190011
Open DOI Search in Google Scholar Back to article
Mair KM, Johansen AK, Wright AF, Wallace E, MacLean MR. Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response. Br J Pharmacol. 2014 Feb;171(3):567-79. doi: 10.1111/bph.12281
Open DOI Search in Google Scholar Back to article
Galiè N, Channick RN, Frantz RP, et al. Risk stratification and medical therapy of pulmonary arterial hypertension. Eur Respir J. 2019 Jan 24;53(1):1801889. doi: 10.1183/13993003.01889-2018
Open DOI Search in Google Scholar Back to article
Humbert M, McLaughlin V, Gibbs JSR, et al.; PULSAR Trial Investigators. Sotatercept for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2021 Apr 1;384(13):1204-1215. doi: 10.1056/NEJMoa2024277
Open DOI Search in Google Scholar Back to article
Hoeper MM, Badesch DB, Ghofrani HA, et al.; STELLAR Trial Investigators. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2023 Apr 20;388(16):1478-1490. doi: 10.1056/NEJMoa2213558
Open DOI Search in Google Scholar Back to article
Frantz RP, Benza RL, Channick RN, et al. TORREY, a Phase 2 study to evaluate the efficacy and safety of inhaled seralutinib for the treatment of pulmonary arterial hypertension. Pulm Circ. 2021 Nov 11;11(4):20458940211057071. doi: 10.1177/20458940211057071
Open DOI Search in Google Scholar Back to article
Gillies H, Niven R, Dake BT, et al. AV-101, a novel inhaled dry-powder formulation of imatinib, in healthy adult participants: a phase 1 single and multiple ascending dose study. ERJ Open Res. 2023 Mar 13;9(2):00433-2022. doi: 10.1183/23120541.00433-2022
Open DOI Search in Google Scholar Back to article
Oliveira LFTS, Chiavegato LD, Arakaki JSO, et al. Prevalence of sexual dysfunction in women with pulmonary hypertension and associated factors. Heart Lung. 2021 Sep-Oct;50(5):714-719. doi: 10.1016/j.hrtlng.2021.04.018
Open DOI Search in Google Scholar Back to article
Guillevin L, Armstrong I, Aldrighetti R, et al. Understanding the impact of pulmonary arterial hypertension on patients’ and carers’ lives. Eur Respir Rev. 2013 Dec;22(130):535-42. doi: 10.1183/09059180.00005713
Open DOI Search in Google Scholar Back to article
Cipolletta S, Ravasio G, Bussotti M. Sexual and Reproductive Health in Women with Pulmonary Hypertension: A Qualitative Study. Arch Sex Behav. 2022 Apr;51(3):1647-1657. doi: 10.1007/s10508-022-02284-w
Open DOI Search in Google Scholar Back to article
Olsson KM, Channick R. Pregnancy in pulmonary arterial hypertension. Eur Respir Rev. 2016 Dec;25(142):431-437. doi: 10.1183/16000617.0079-2016
Open DOI Search in Google Scholar Back to article
Olsson KM, Jais X. Birth control and pregnancy management in pulmonary hypertension. Semin Respir Crit Care Med. 2013 Oct;34(5):681-8. doi: 10.1055/s-0033-1355438
Open DOI Search in Google Scholar Back to article
Ma R, Gao H, Cui J, et al. Pregnancy feasibility in women with mild pulmonary arterial hypertension: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2023 Jun 8;23(1):427. doi: 10.1186/s12884-023-05752-w
Open DOI Search in Google Scholar Back to article
Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost. 2003 Apr;29(2):125-30. doi: 10.1055/s-2003-38897
Open DOI Search in Google Scholar Back to article
Hemnes AR, Kiely DG, Cockrill BA, et al. Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute. Pulm Circ. 2015 Sep;5(3):435-65. doi: 10.1086/682230
Open DOI Search in Google Scholar Back to article
Chen W, Luo J, Chen J, et al. Effect of multidisciplinary team (MDT) centred on pregnant women with pulmonary hypertension on treatment and outcomes of pregnancy. BMC Pulm Med. 2023 Feb 11;23(1):62. doi: 10.1186/s12890-023-02355-1
Open DOI Search in Google Scholar Back to article
Vaidya A, Oliveros E, Mulla W, Feinstein D, Hart L, Forfia P. Management of Pulmonary Arterial Hypertension in Pregnancy: Experience from a Nationally Accredited Center. J Cardiovasc Dev Dis. 2022 Jun 18;9(6):195. doi: 10.3390/jcdd9060195
Open DOI Search in Google Scholar Back to article
Safdar Z. Pulmonary arterial hypertension in pregnant women. Ther Adv Respir Dis. 2013 Feb;7(1):51-63. doi: 10.1177/1753465812461680
Open DOI Search in Google Scholar Back to article
Griva P, Stamatakis E, Varvarousi G, Loukeri A, Valsamidis D. The Use of Vigileo® Monitor in a Parturient With Severe Mitral Valve Stenosis and Severe Pulmonary Hypertension Undergoing Cesarean Section Under General Anesthesia: A Case Report and Literature Review. Cureus. 2022 Dec 7;14(12):e32284. doi: 10.7759/cureus.32284
Open DOI Search in Google Scholar Back to article
Zhang Q, Zhu F, Shi G, et al. Maternal Outcomes Among Pregnant Women With Congenital Heart Disease-Associated Pulmonary Hypertension. Circulation. 2023 Feb 14;147(7):549-561. doi: 10.1161/CIRCULATIONAHA.122.057987
Open DOI Search in Google Scholar Back to article
Ma L, Liu W, Huang Y. Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive cases. Front Med. 2012 Sep;6(3):307-10. doi: 10.1007/s11684-012-0209-3
Open DOI Search in Google Scholar Back to article
Lv C, Huang Y, Liao G, Wu L, Chen D, Gao Y. Pregnancy outcomes in women with pulmonary hypertension: a retrospective study in China. BMC Pregnancy Childbirth. 2023 Jan 9;23(1):16. doi: 10.1186/s12884-023-05353-7
Open DOI Search in Google Scholar Back to article
Corbach N, Berlier C, Lichtblau M, et al. Favorable Pregnancy Outcomes in Women With Well-Controlled Pulmonary Arterial Hypertension. Front Med (Lausanne). 2021 Jul 5;8:689764. doi: 10.3389/fmed.2021.689764
Open DOI Search in Google Scholar Back to article
Duarte AG, Thomas S, Safdar Z, et al. Management of pulmonary arterial hypertension during pregnancy: a retrospective, multicenter experience. Chest. 2013 May;143(5):1330-1336. doi: 10.1378/chest.12-0528
Open DOI Search in Google Scholar Back to article
Halpern DG, Weinberg CR, Pinnelas R, Mehta-Lee S, Economy KE, Valente AM. Use of Medication for Cardiovascular Disease During Pregnancy: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 Feb 5;73(4):457-476. doi: 10.1016/j.jacc.2018.10.075
Open DOI Search in Google Scholar Back to article
Wollein U, Schech B, Hardt J, Schramek N. Determination and quantitation of sildenafil and its major metabolite in the breast milk of a lactating woman. J Pharm Biomed Anal. 2016 Feb 20;120:100-5. doi: 10.1016/j.jpba.2015.12.006
Open DOI Search in Google Scholar Back to article
Nauwelaerts N, Ceulemans M, Deferm N, et al. Case Report: Bosentan and Sildenafil Exposure in Human Milk - A Contribution From the ConcePTION Project. Front Pharmacol. 2022 Jun 15;13:881084. doi: 10.3389/fphar.2022.881084
Open DOI Search in Google Scholar Back to article
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda, MD: National Institute of Child Health and Human Development; 2006-2023. Sildenafil; 2022 Jul 18 [cited 2023 Dec 29]. Available at: https://pubmed.ncbi.nlm.nih.gov/29999677
Search in Google Scholar Back to article
Nauwelaerts N, Ceulemans M, Deferm N, et al. Case Report: Bosentan and Sildenafil Exposure in Human Milk - A Contribution From the ConcePTION Project. Front Pharmacol. 2022 Jun 15;13:881084. doi: 10.3389/fphar.2022.881084
Open DOI Search in Google Scholar Back to article
Molelekwa V, Akhter P, McKenna P, Bowen M, Walsh K. Eisenmenger’s syndrome in a 27 week pregnancy--management with bosentan and sildenafil. Ir Med J. 2005 Mar;98(3):87-8. PMID: 15869069
Search in Google Scholar Back to article

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DOI: https://doi.org/10.14797/mdcvj.1308 | Journal eISSN: 1947-6108

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Language: English

Page range: 70 - 80

Submitted on: Nov 15, 2023

Accepted on: Dec 20, 2023

Published on: Mar 14, 2024

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

pulmonary hypertension,

pulmonary arterial hypertension,

heart disease in women,

estrogen paradox

© 2024 Eunwoo Park, Zeenat Safdar, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 20 (2024): Issue 2