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Arrhythmias in COVID-19 Cover

References

  1. Azevedo RB, Botelho BG, Hollanda JVG, et al. Covid-19 and the cardiovascular system: a comprehensive review. J Hum Hypertens. 2021 Jan;35(1):411. doi: 10.1038/s41371-020-0387-4
  2. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):10611069. doi: 10.1001/jama.2020.1585
  3. Griffin DO, Brennan-Rieder D, Ngo B, et al. The Importance of Understanding the Stages of COVID-19 in Treatment and Trials. AIDS Rev. 2021 Feb 8;23(1):4047. doi: 10.24875/AIDSRev.200001261
  4. Atri D, Siddiqi HK, Lang JP, et al. COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies. JACC Basic Transl Sci. 2020 Apr 10;5(5):518536. doi: 10.1016/j.jacbts.2020.04.002
  5. Lazzerini PE, Capecchi PL, Laghi-Pasini F. Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis. Eur Heart J. 2017 Jun 7;38(22):17171727. doi: 10.1093/eurheartj/ehw208
  6. Lazzerini PE, Laghi-Pasini F, Boutjdir M, Capecchi PL. Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies. Nat Rev Immunol. 2019 Jan;19(1):6364. doi: 10.1038/s41577-018-0098-z
  7. Clark RE, Christlieb I, Sanmarco M, Diaz-Perez R, Dammann JF, Zipser ME. Relationship of hypoxia to arrhythmia and cardiac conduction hemorrhage. Circulation. 1963 Apr 1;27:742747. doi: 10.1161/01.CIR.27.4.742
  8. Macdonald WA, Hool LC. The effect of acute hypoxia on excitability in the heart and the L-type calcium channel as a therapeutic target. Curr Drug Discov Technol. 2008 Dec;5(4):30211. doi: 10.2174/157016308786733546
  9. Lazzerini PE, Boutjdir M, Capecchi PL. COVID-19, Arrhythmic Risk, and Inflammation: Mind the Gap! Circulation. 2020 Jul 7;142(1):79. doi: 10.1161/CIRCULATIONAHA.120.047293
  10. Kolettis TM. Coronary artery disease and ventricular tachyarrhythmia: pathophysiology and treatment. Curr Opin Pharmacol. 2013 Apr;13(2):2107. doi: 10.1016/j.coph.2013.01.001
  11. Gemel J, Su Z, Gileles-Hillel A, Khalyfa A, Gozal D, Beyer EC. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC Cell Biol. 2017 Jan 17;18(Suppl 1):7. doi: 10.1186/s12860-016-0117-5
  12. Chen C, Chen C, Yan JT, Zhou N, Zhao JP, Wang DW. [Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19]. Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Jul 24;48(7):567571. doi: 10.3760/cma.j.cn112148-20200225-00123
  13. Babapoor-Farrokhran S, Gill D, Walker J, Rasekhi RT, Bozorgnia B, Amanullah A. Myocardial injury and COVID-19: Possible mechanisms. Life Sci. 2020 Jul 15;253:117723. doi: 10.1016/j.lfs.2020.117723
  14. Peretto G, Sala S, Rizzo S, et al. Arrhythmias in myocarditis: State of the art. Heart Rhythm. 2019 May;16(5):793801. doi: 10.1016/j.hrthm.2018.11.024
  15. Mercuro NJ, Yen CF, Shim DJ, et al. Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020 Sep 1;5(9):10361041. doi: 10.1001/jamacardio.2020.1834
  16. Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ. Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19). Mayo Clin Proc. 2020 Jun;95(6):12131221. doi: 10.1016/j.mayocp.2020.03.024
  17. Dherange P, Lang J, Qian P, et al. Arrhythmias and COVID-19: A Review. JACC Clin Electrophysiol. 2020 Sep;6(9):11931204. doi: 10.1016/j.jacep.2020.08.002
  18. Amaratunga EA, Corwin DS, Moran L, Snyder R. Bradycardia in Patients With COVID-19: A Calm Before the Storm? Cureus. 2020 Jun 13;12(6):e8599. doi: 10.7759/cureus.8599
  19. Gautret P, Lagier JC, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020 Jul;56(1):105949. doi: 10.1016/j.ijantimicag.2020.105949
  20. Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19. N Engl J Med. 2020 Nov 19;383(21):e119. doi: 10.1056/NEJMx200021
  21. Chang D, Saleh M, Gabriels J, et al. Inpatient Use of Ambulatory Telemetry Monitors for COVID-19 Patients Treated With Hydroxychloroquine and/or Azithromycin. J Am Coll Cardiol. 2020 Jun 16;75(23):29922993. doi: 10.1016/j.jacc.2020.04.032
  22. Mazzanti A, Briani M, Kukavica D, et al. Association of Hydroxychloroquine With QTc Interval in Patients With COVID-19. Circulation. 2020 Aug 4;142(5):513515. doi: 10.1161/CIRCULATIONAHA.120.048476
  23. Jankelson L, Karam G, Becker ML, Chinitz LA, Tsai MC. QT prolongation, torsades de pointes, and sudden death with short courses of chloroquine or hydroxychloroquine as used in COVID-19: A systematic review. Heart Rhythm. 2020 Sep;17(9):14721479. doi: 10.1016/j.hrthm.2020.05.008
  24. Chu CM, Cheng VC, Hung IF, et al. Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. Thorax. 2004 Mar;59(3):2526. doi: 10.1136/thorax.2003.012658
  25. Kim UJ, Won EJ, Kee SJ, Jung SI, Jang HC. Combination therapy with lopinavir/ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome. Antivir Ther. 2016;21(5):4559. doi: 10.3851/IMP3002
  26. Chaubey SK, Sinha AK, Phillips E, Russell DB, Falhammar H. Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection. Sex Health. 2009 Sep;6(3):2547. doi: 10.1071/SH09005
  27. Beyls C, Martin N, Hermida A, Abou-Arab O, Mahjoub Y. Lopinavir-Ritonavir Treatment for COVID-19 Infection in Intensive Care Unit: Risk of Bradycardia. Circ Arrhythm Electrophysiol. 2020 Aug;13(8):e008798. doi: 10.1161/CIRCEP.120.008798
  28. Cao B, Wang Y, Wen D, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020 May 7;382(19):17871799. doi: 10.1056/NEJMoa2001282
  29. Beigel JH, Tomashek KM, Dodd LE, et al. Remdesivir for the Treatment of Covid-19 - Final Report. N Engl J Med. 2020 Nov 5;383(19):18131826. doi: 10.1056/NEJMoa2007764
  30. Spinner CD, Gottlieb RL, Criner GJ, et al. Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial. JAMA. 2020 Sep 15;324(11):10481057. doi: 10.1001/jama.2020.16349
  31. Gubitosa JC, Kakar P, Gerula C, et al. Marked Sinus Bradycardia Associated With Remdesivir in COVID-19: A Case and Literature Review. JACC Case Rep. 2020 Nov 18;2(14):22602264. doi: 10.1016/j.jaccas.2020.08.025
  32. Barkas F, Styla CP, Bechlioulis A, Milionis H, Liberopoulos E. Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review. J Cardiovasc Dev Dis. 2021 Feb 12;8(2):18. doi: 10.3390/jcdd8020018
  33. Gupta AK, Parker BM, Priyadarshi V, Parker J. Cardiac Adverse Events With Remdesivir in COVID-19 Infection. Cureus. 2020 Oct 24;12(10):e11132. doi: 10.7759/cureus.11132
  34. Touafchia A, Bagheri H, Carrié D, et al. Serious bradycardia and remdesivir for coronavirus 2019 (COVID-19): a new safety concerns. Clin Microbiol Infect. 2021 Feb 27;27(5):791.e5791.e8. doi: 10.1016/j.cmi.2021.02.013
  35. Gupta S, Wang W, Hayek SS, et al. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Intern Med. 2021 Jan 1;181(1):4151. doi: 10.1001/jamainternmed.2020.6252
  36. Salama C, Han J, Yau L, et al. Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia. N Engl J Med. 2021 Jan 7;384(1):2030. doi: 10.1056/NEJMoa2030340
  37. Lazzerini PE, Acampa M, Capecchi PL, et al. Antiarrhythmic potential of anticytokine therapy in rheumatoid arthritis: tocilizumab reduces corrected QT interval by controlling systemic inflammation. Arthritis Care Res (Hoboken). 2015 Mar;67(3):3329. doi: 10.1002/acr.22455
  38. Horby P, Lim WS, Emberson JR, et al. RECOVERY Collaborative Group. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021 Feb 25;384(8):693704. doi: 10.1056/NEJMoa2021436
  39. van der Hooft CS, Heeringa J, Brusselle GG, et al. Corticosteroids and the risk of atrial fibrillation. Arch Intern Med. 2006 May 8;166(9):101620. doi: 10.1001/archinte.166.9.1016
  40. Liu Q, Kong AL, Chen R, et al. Propofol and arrhythmias: two sides of the coin. Acta Pharmacol Sin. 2011 Jun;32(6):81723. doi: 10.1038/aps.2011.42
  41. Jakob SM, Ruokonen E, Grounds RM, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012 Mar 21;307(11):115160. doi: 10.1001/jama.2012.304
  42. Kako H, Krishna SG, Sebastian R, Smith K, Tobias JD. Effect of dexmedetomidine on the QT interval in pediatric patients undergoing general anesthesia. J Anesth. 2015 Dec;29(6):8627. doi: 10.1007/s00540-015-2056-2
  43. Zhou WJ, Liu M, Fan XP. Differences in efficacy and safety of midazolam vs. dexmedetomidine in critically ill patients: A meta-analysis of randomized controlled trial. Exp Ther Med. 2021 Feb;21(2):156. doi: 10.3892/etm.2020.9297
  44. Zareini B, Rajan D, El-Sheikh M, et al. Cardiac arrhythmias in patients hospitalized with COVID-19: The ACOVID study. Heart Rhythm O2. 2021 Mar 23;2(3):304308. doi: 10.1016/j.hroo.2021.03.008
  45. Cho JH, Namazi A, Shelton R, et al. Cardiac arrhythmias in hospitalized patients with COVID-19: A prospective observational study in the western United States. PLoS One. 2020 Dec 28;15(12):e0244533. doi: 10.1371/journal.pone.0244533
  46. Bhatla A, Mayer MM, Adusumalli S, et al. COVID-19 and cardiac arrhythmias. Hearth Rhythm. 2020 Sep;17(9):14391444. doi: 10.1016/j.hrthm.2020.06.016
  47. Musikantow DR, Turagam MK, Sartori S, et al. Atrial Fibrillation in Patients Hospitalized With COVID-19: Incidence, Predictors, Outcomes, and Comparison to Influenza. JACC Clin Electrophysiol. 2021 Sep;7(9):11201130. doi: 10.1016/j.jacep.2021.02.009
  48. Ip RJ, Ali A, Baloch ZQ, et al. Atrial Fibrillation as a Predictor of Mortality in High Risk COVID-19 Patients: A Multicentre Study of 171 Patients. Heart Lung Circ. 2021 Aug;30(8):11511156. doi: 10.1016/j.hlc.2021.02.010
  49. Mountantonakis SE, Saleh M, Fishbein J, et al. Atrial fibrillation is an independent predictor for in-hospital mortality in patients admitted with SARS-CoV-2 infection. Heart Rhythm. 2021 Apr;18(4):501507. doi: 10.1016/j.hrthm.2021.01.018
  50. Yarmohammadi H, Morrow JP, Dizon J, et al. Frequency of Atrial Arrhythmia in Hospitalized Patients With COVID-19. Am J Cardiol. 2021 May 15;147:5257. doi: 10.1016/j.amjcard.2021.01.039
  51. Abrams MP, Coromilas EJ, Wan EY, Rubin GA, Garan H, Dizon JM. Malignant ventricular arrhythmias in patients with severe acute respiratory distress syndrome due to COVID-19 without significant structural heart disease. HeartRhythm Case Rep. 2020 Nov;6(11):858862. doi: 10.1016/j.hrcr.2020.08.017
  52. Shao F, Xu S, Ma X, et al. In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan, China. Resuscitation. 2020 Jun;151:1823. doi: 10.1016/j.resuscitation.2020.04.005
  53. Chinitz JS, Goyal R, Harding M, et al. Bradyarrhythmias in patients with COVID-19: Marker of poor prognosis? Pacing Clin Electrophysiol. 2020 Oct;43(10):11991204. doi: 10.1111/pace.14042
  54. Kumar S, Arcuri C, Chaudhuri S, et al. A novel study on SARS-COV-2 virus associated bradycardia as a predictor of mortality-retrospective multicenter analysis. Clin Cardiol. 2021 Jun;44(6):857862. doi: 10.1002/clc.23622
  55. Li Y, Liu T, Tse G, et al. Electrocardiograhic characteristics in patients with coronavirus infection: A single-center observational study. Ann Noninvasive Electrocardiol. 2020 Sep;25(6):e12805. doi: 10.1111/anec.12805
  56. Berman JP, Abrams MP, Kushnir A, et al. Cardiac electrophysiology consultative experience at the epicenter of the COVID-19 pandemic in the United States. Indian Pacing Electrophysiol J. Nov-Dec 2020;20(6):250256. doi: 10.1016/j.ipej.2020.08.006
  57. Desai AD, Boursiquot BC, Melki L, Wan EY. Management of Arrhythmias Associated with COVID-19. Curr Cardiol Rep. 2020 Nov 24;23(1):2. doi: 10.1007/s11886-020-01434-7
  58. Romero-Sánchez CM, Díaz-Maroto I, Fernández-Díaz E, et al. Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry. Neurology. 2020 Aug 25;95(8):e1060e1070. doi: 10.1212/WNL.0000000000009937
  59. Shouman K, Vanichkachorn G, Cheshire WP, et al. Autonomic dysfunction following COVID-19 infection: an early experience. Clin Auton Res. 2021 Jun;31(3):385394. doi: 10.1007/s10286-021-00803-8
  60. Arano Llach J, Victor Bazan VBG, Gemma Llados GLL, et al. Inappropriate sinus tachycardia in post-covid-19 Syndrome. Europace. 2021 May;23(Suppl 3):euab116.114. doi: 10.1093/europace/euab116.114
DOI: https://doi.org/10.14797/mdcvj.1039 | Journal eISSN: 1947-6108
Language: English
Page range: 73 - 82
Submitted on: Sep 17, 2021
Accepted on: Sep 17, 2021
Published on: Dec 15, 2021
In partnership with: Paradigm Publishing Services

© 2021 Summit Pandat, Zhihao Zhu, Stephanie Fuentes-Rojas, Paul Schurmann, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.