Therapeutic Transdifferentiation: Can we Generate Cardiac Tissue Rather Than Scar after Myocardial Injury?
By: Nazish Sayed, Wing Tak Wong and John P. Cooke
Abstract
After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.
DOI: https://doi.org/10.14797/mdcj-9-4-210 | Journal eISSN: 1947-6108
Language: English
Page range: 210 - 212
Published on: Oct 1, 2013
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services
Keywords:
© 2013 Nazish Sayed, Wing Tak Wong, John P. Cooke, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.