Skip to main content
Have a personal or library account? Click to login
Inorganic Nitrate Supplementation for Cardiovascular Health Cover

Inorganic Nitrate Supplementation for Cardiovascular Health

By:   
Open Access
|Jul 2019

References

  1. Förstermann U Sessa WC Nitric oxide synthases: regulation and function Eur Heart J 2017 April 1 33 7 829 37
  2. Taddei S Virdis A Ghiadoni L Age-related reduction of NO availability and oxidative stress in humans Hypertension 2001 Aug 1 38 2 274 9
  3. Lundberg JO Weitzberg E Gladwin MT The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics Nat Rev Drug Disc 2008 Feb 1 7 2 156 67
  4. Martin MJ Jimenez MV New issues about nitric oxide and its effects on the gastrointestinal tract Curr Pharm Des 2001 Oct 1 7 10 881 908
  5. Lidder S Webb AJ Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway Br J Clin Pharmcol 2012 Aug 13 75 3 677 97
  6. Kevil CG Kolluru GK Pattillo CB Giordano T Inorganic nitrite therapy: historical perspective and future directions Free Radical Biol Med 2011 Aug 1 51 3 565 794
  7. Rees DD Palmer RMJ Moncada S Role of endothelium-derived nitric oxide in the regulation of blood pressure Proc Natl Acad Sci USA 1989 May 1 86 9 3375 8
  8. Vallance P Collier J Moncada S Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man Lancet 1989 Oct 28 334 8670 997 1000
  9. Webb AJ Patel N Loukogeorgakis S Acute blood pressure lowering, vasoprotective and anti-platelet properties of dietary nitrate via bioconversion to nitrite Hypertension 2008 Mar 1 51 3 784 90
  10. Vanhatalo A Bailey SJ Blackwell JR Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise Am J Physiol Regul Integr Comp Physiol 2010 Oct 1 299 4 R1121 31
  11. Lansley KE Winyard PG Fulford J Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study J Appl Physiol 2011 Mar 1 110 3 591 600
  12. Wylie LJ Kelly J Bailey SJ Beet juice and exercise: pharmacodynamics and dose-response relationships J Appl Physiol 2013 Aug 1 115 3 325 36
  13. Kenjale AA Ham KL Stabler T Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease J Appl Physiol 2011 Jun 1 110 6 1582 91
  14. Ghosh SM Kapil V Fuentes-Calvo Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential Hypertension 2013 May 1 61 5 1091 1102
  15. Hobbs DA George TW Lovegrove JA The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies Nut Res Rev 2013 Dec 1 26 2 210 22
  16. Lara J Ashor AW Oggioni C Ahluwalia A Mathers JC Siervo M Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis Eur J Nutr 2016 Mar 1 55 2 451 9
  17. Machha A Schechter AN Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits Eur J Nutr 2011 Aug 1 50 5 293 303
  18. Richardson G Hicks SL O'Byrne S The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans Nitric Oxide 2002 Aug 1 7 1 24 29
  19. Velmurugan S Kapil V Ghosh SM Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex Free Radic Biol Med 2013 Dec 1 65 1521 32
  20. Apostoli GL Solomon A Smallwood MJ Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo J Thromb Haemost 2014 Nov 1 12 11 1880 9
  21. Totani L Evangelista V Platelet-leukocyte interactions in cardiovascular disease and beyond Arterioscler Thromb Vasc Biol 2010 Dec 1 30 12 2357 61
  22. Rosenfeld ME Cellular mechanisms in the development of atherosclerosis Diabetes Res Clin Pract 1996 Feb 1 30 Suppl 1 S1 S11
  23. Kubes P Suzuki M Granger DN Nitric oxide: An endogenous modulator of leukocyte adhesion Proc Natl Acad Sci USA 1991 June 1 88 11 4651 5
  24. Hayakawa H Raij L Relationship between hypercholesterolaemia, endothelial dysfunction and hypertension J Hypertens 1999 May 1 17 5 611 9
  25. Stokes KY Dugas TR Tang Y Garg H Guidry E Bryan NS Dietary nitrite prevents hypercholesterolemia microvascular inflammation and reverses endothelial dysfunction Am J Physiol Heart Circ Physiol 2009 May 1 296 5 H281 8
  26. Jädert C Petersson J Massena S Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury Free Radic Biol Med 2012 Feb 1 52 3 683 92
  27. Garg UC Hassid A Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells J Clin Invest 1989 May 1 83 5 1774 7
  28. Sarkar R Meinberg EG Stanley JC Gordon D Webb RC Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells Circ Res 1996 Feb 1 78 2 225 30
  29. Alef MJ Vallabhaneni R Carchman E Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats J Clin Invest 2011 April 1 121 4 1646 56
  30. Hermández A Schiffer TA Ivarsson N Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscle J Physiol 2001 Aug 1 590 15 3575 83
  31. Haider G Folland JP Nitrate supplementation enhances the contractile properties of human skeletal muscle Med Sci Sports Exerc 2014 Dec 1 48 12 2234 43
  32. Coggan AR Leibowitz JL Kadkhodayan A Effect of acute dietary nitrate intake on maximal knee extensor speed and power in healthy men and women Nitric Oxide 2015 Aug 1 48 16 21
  33. Coggan AR Leibowitz JL Spearie CA Acute dietary nitrate intake improves muscle contractile function in patients with heart failure: A double-blind, placebo-controlled, randomized trial Circ Heart Fail 2015 Sep 1 8 5 914 20
  34. Pironti G Ivarsson N Yang J Dietary nitrate improves cardiac contractility via enhanced cellular Ca2+ signaling Basic Res Cardiol 2016 May 1 111 3 34 47
  35. Zamani P Rawat D Shiva-Kumar P Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction Circulation 2015 Jan 27 131 4 371 80
  36. Borlaug BA Koepp KE Melenovsky V Sodium nitrite improves exercise hemodynamics and ventricular performance in heart failure with preserved ejection fraction J Am Coll Cardiol 2015 Oct 13 66 15 1672 82
  37. Bryan NS Functional nitric oxide nutrition to combat cardiovascular disease Curr Atheroscler Rep 2018 Mar 17 20 5 21 33
  38. Jackson JK Patterson AJ MacDonald-Wicks LK Oldmeadow C McEvoy MA The role of inorganic nitrate and nitrite in cardiovascular disease risk factors: a systematic review and meta-analysis of human evidence Nutr Rev 2018 May 1 76 5 348 71
  39. Mensinga TT Speijers GJ Meulenbelt J Health implications of exposure to environmental nitrogenous compounds Toxicol Rev 2003 Jan 1 22 1 41 51
  40. Santamaria P Nitrate in vegetables: toxicity, content, intake and EC regulation J Sci Food Agr. 2006 Jan 15 86 1 10 7
  41. Hord NG Tang Y Bryan NS Food sources of nitrates: the physiologic context for potential health benefits Am J Clin Nutr 2009 Jul 1 90 1 1 10
Language: English
Page range: 200 - 206
Published on: Jul 1, 2019
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services

© 2019 John L. Ivy, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.