Spontaneous Closure of a Secundum Atrial Septal Defect

Stephen Y. Wang; Terrence D. Welch; Aryé Elfenbein; Aaron V. Kaplan

doi:10.14797/mdcj-14-1-60

Spontaneous Closure of a Secundum Atrial Septal Defect

Methodist DeBakey Cardiovascular Journal

Volume 14 (2018): Issue 1

By: Stephen Y. Wang, Terrence D. Welch, Aryé Elfenbein and Aaron V. Kaplan

Open Access

|Jan 2018

Abstract

Spontaneous closure of an atrial septal defect (ASD) is well described in pediatric cardiology but may be less familiar to adult internists and cardiologists. We report a moderately sized 6-mm ASD that closed spontaneously without intervention. A literature review found that a smaller defect size and an early age of diagnosis are the most important predictors of closure. Possible mechanisms of a spontaneous ASD closure include adaptive endothelial migration, limited myocardial proliferation, and fibroblast migration with extracellular matrix deposition.

References

van der Linde D , Konings EE , Slager MA , Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol. 2011 Nov 15; 58 21: 2241– 7.
Search in Google Scholar Back to article
Helgason H Jonsdottir G. Spontaneous closure of atrial septal defects. Pediatr Cardiol. 1999 May–Jun; 20 3: 195– 9.
Search in Google Scholar Back to article
Brassard M , Fouron JC , van Doesburg NH , Mercier LA , De Guise P. Outcome of children with atrial septal defect considered too small for surgical closure. Am J Cardiol. 1999 Jun 1; 83 11: 1552– 5.
Search in Google Scholar Back to article
Cockerham JT , Martin TC , Gutierrez FR , Hartmann AF Jr , Goldring D , Strauss AW. Spontaneous closure of secundum atrial septal defect in infants and young children. Am J Cardiol. 1983 Dec 1; 52 10: 1267– 71.
Search in Google Scholar Back to article
Demir T , Oztunç F , Ero&gcaron;lu AG , Outcome for patients with isolated atrial septal defects in the oval fossa diagnosed in infancy. Cardiol Young. 2008 Feb; 18 1: 75– 8.
Search in Google Scholar Back to article
Garne E. Atrial and ventricular septal defects - epidemiology and spontaneous closure. J Matern Fetal Neonatal Med. 2006 May; 19 5: 271– 6.
Search in Google Scholar Back to article
Hanslik A , Pospisil U , Salzer-Muhar U , Greber-Platzer S , Male C. Predictors of spontaneous closure of isolated secundum atrial septal defect in children: a longitudinal study. Pediatrics. 2006 Oct; 118 4: 1560– 5.
Search in Google Scholar Back to article
McMahon CJ , Feltes TF , Fraley JK , Natural history of growth of secundum atrial septal defects and implications for transcatheter closure. Heart. 2002 Mar; 87 3: 256– 9.
Search in Google Scholar Back to article
Mody MR. Serial hemodynamic observations in secundum atrial septal defect with special reference to spontaneous closure. Am J Cardiol. 1973 Dec; 32 7: 978– 81.
Search in Google Scholar Back to article
Ozcelik N , Atalay S , Tutar E , Ekici F , Atasay B. The prevalence of interatrial septal openings in newborns and predictive factors for spontaneous closure. Int J Cardiol. 2006 Apr 4; 108 2: 207– 11.
Search in Google Scholar Back to article
Radzik D , Davignon A , van Doesburg N , Fournier A , Marchand T , Ducharme G. Predictive factors for spontaneous closure of atrial septal defects diagnosed in the first 3 months of life. J Am Coll Cardiol. 1993 Sep; 22 3: 851– 3.
Search in Google Scholar Back to article
Riggs T , Sharp SE , Batton D , Hussey ME , Weinhouse E. Spontaneous closure of atrial septal defects in premature vs. full-term neonates. Pediatr Cardiol. 2000 Mar–Apr; 21 2: 129– 34.
Search in Google Scholar Back to article
Fukazawa M , Fukushige J , Ueda K. Atrial septal defects in neonates with reference to spontaneous closure. Am Heart J. 1988 Jul; 116 1 Pt 1: 123– 7.
Search in Google Scholar Back to article
Azhari N , Shihata MS , Al-Fatani A. Spontaneous closure of atrial septal defects within the oval fossa. Cardiol Young. 2004 Apr; 14 2: 148– 55.
Search in Google Scholar Back to article
Fiszer R , Szkutnik M , Chodór B , Białkowski J. Spontaneous closure of a large atrial septal defect in an infant. Postepy Kardiol Interwencyjnej. 2014; 10 4: 264– 6.
Search in Google Scholar Back to article
Baeyens N , Bandyopadhyay C , Coon BG , Yun S , Schwartz MA. Endothelial fluid shear stress sensing in vascular health and disease. J Clin Invest. 2016 Mar 1; 126 3: 821– 8.
Search in Google Scholar Back to article
Uygur A Lee RT. Mechanisms of Cardiac Regeneration. Dev Cell. 2016 Feb 22; 36 4: 362– 74.
Search in Google Scholar Back to article
Ali SR , Hippenmeyer S , Saadat LV , Luo L , Weissman IL , Ardehali R. Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice. Proc Natl Acad Sci U S A. 2014 Jun 17; 111 24: 8850– 5.
Search in Google Scholar Back to article
Han P , Bloomekatz J , Ren J , Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 2016 Jun 30; 534 7609: 700– 4.
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.14797/mdcj-14-1-60 | Journal eISSN: 1947-6108

Journal RSS Feed

Language: English

Page range: 60 - 62

Published on: Jan 1, 2018

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

cardiology,

congenital heart disease,

atrial septal defect

© 2018 Stephen Y. Wang, Terrence D. Welch, Aryé Elfenbein, Aaron V. Kaplan, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 14 (2018): Issue 1