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Updates on the Management of Severe Asthma Cover

Updates on the Management of Severe Asthma

By:  and    
Open Access
|Apr 2017

References

  1. Moore WC , Bleecker ER , Curran-Everett D , Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2007 Feb; 119 2: 40513.
  2. Chung KF , Wenzel SE , Brozek JL , International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014 Feb; 43 2: 34373.
  3. Currie GP , Devereux GS , Lee DK , Ayres JG. Recent developments in asthma management. BMJ. 2005 Mar 12; 330 7491: 5859.
  4. Barnes PJ. Severe asthma: advances in current management and future therapy. J Allergy Clin Immunol. 2012 Jan; 129 1: 4859.
  5. Licari A , Marseglia G , Castagnoli R , Marseglia A , Ciprandi G. The discovery and development of omalizumab for the treatment of asthma. Expert Opin Drug Discov. 2015; 10 9: 103342.
  6. Milgrom H , Fick RB Jr , Su JQ , Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group. N Engl J Med. 1999 Dec 23; 341 26: 196673.
  7. Hanania NA , Alpan O , Hamilos DL , Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. Ann Intern Med. 2011 May 3; 154 9: 57382.
  8. Wenzel S , Ford L , Pearlman D , Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013 Jun 27; 368 26: 245566.
  9. Gevaert P , Van Bruaene N , Cattaert T , Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol. 2011 Nov; 128 5: 98995.
  10. Ortega H , Liu M , Pavord I , Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014 Sep 25; 371 13: 1198207.
  11. Pavord ID , Korn S , Howarth P , Mepolizumab for severe eosinophilic asthma (DREAM): a multicenter, double-blind, placebo-controlled trial. Lancet. 2012 Aug 18; 380 9842: 6519.
  12. Bel EH , Wenzel SE , Thompson PJ , Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014 Sep 25; 371 13: 118997.
  13. Castro M , Zangrilli J , Wechsler ME , Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomized, placebo-controlled, phase 3 trials. Lancet Respir Med. 2015 May; 3 5: 35566.
  14. Bjermer L , Lemiere C , Maspero J , Weiss S , Zangrilli J , Germinaro M. Reslizumab for Inadequately Controlled Asthma with Elevated Blood Eosinophil Levels: A Randomized Phase 3 Study. Chest. 2016 Oct; 150 4: 78998.
  15. Gildea TR , Khatri SB , Castro M. Bronchial thermoplasty: a new treatment for severe refractory asthma. Cleve Clin J Med. 2011 Jul; 78 7: 47785.
  16. Cox G , Thomson NC , Rubin AS , Asthma control during the year after bronchial thermoplasty. N Engl J Med. 2007 Mar 29; 356 13: 132737.
  17. Solway J Irvin CG. Airway smooth muscle as a target for asthma therapy. N Engl J Med. 2007 Mar 29; 356 13: 13679.
  18. Pavord ID , Thomson NC , Niven RM , .; Research in Severe Asthma Trial Study Group Safety of bronchial thermoplasty in patients with severe refractory asthma. Ann Allergy Asthma Immunol. 2013 Nov; 111 5: 4027.
  19. Castro M , Rubin AS , Laviolette M , .; AIR2 Trial Study Group Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010 Jan 15; 181 2: 11624.
  20. Castro M , Rubin A , Laviolette M , Hanania NA , Armstrong B , Cox G ; AIR2 Trial Study Group. Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma. Ann Allergy Asthma Immunol. 2011 Jul; 107 1: 6570.
  21. Pavord ID , Cox G , Thomson NC , Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med. 2007 Dec 15; 176 12: 118591.
Language: English
Page range: 82 - 83
Published on: Apr 1, 2017
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services

© 2017 Atif Siddiqui, Lisa Kopas, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.