Mechanical Valve Thrombosis on Rivaroxaban: Are Novel Anticoagulants Really an Option?
References
- Stewart RA , Astell H , Young L , White HD. Thrombosis on a Mechanical Aortic Valve whilst Anti-coagulated With Dabigatran. Heart Lung Circ. 2012 Jan; 21 1: 53– 5.
- Price J , Hynes M , Labinaz M , Ruel M , Boodhwani M. Mechanical valve thrombosis with dabigatran. J Am Coll Cardiol. 2012 Oct 23; 60 17: 1710– 1.
- McKellar SH , Abel S , Camp CL , Suri RM , Ereth MH , Schaff HV. Effectiveness of dabigatran etexilate for thromboprophylaxis of mechanical heart valves. J Thorac Cardiovasc Surg. 2011 Jun; 141 6: 1410– 6.
- Eikelboom JW , Connolly SJ , Brueckmann M , Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med. 2013 Sep 26; 369 13: 1206– 14.
- U. S. Food and Drug Administration [Internet]. Silver Spring: U.S. Food and Drug Administration; c2016. FDA Drug Safety Communication: Pradaxa (dabigatran etexilate mesylate) should not be used in patients with mechanical prosthetic heart valves; 2016 Jan 19 [cited 2017 Feb 7]. Available from: http://www.fda.gov/Drugs/DrugSafety/ucm332912.htm.
- Jaffer IH , Stafford AR , Fredenburgh JC , Whitlock RP , Chan NC , Weitz JI. Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation. J Am Heart Assoc. 2015 Aug 24; 4 8: e002322.
- Kaeberich A , Reindl I , Raaz U , Comparison of unfractionated heparin, low-molecular-weight heparin, low-dose and high-dose rivaroxaban in preventing thrombus formation on mechanical heart valves: results of an in vitro study. J Thromb Thrombolysis. 2011 Nov; 32 4: 417– 25.
- Greiten LE , McKellar SH , Rysavy J , Schaff HV. Effectiveness of rivaroxaban for thromboprophylaxis of prosthetic heart valves in a porcine heterotopic valve model. Eur J Cardiothorac Surg. 2014 May; 45 5: 914– 9.
DOI: https://doi.org/10.14797/mdcj-13-2-73 | Journal eISSN: 1947-6108
Language: English
Page range: 73 - 75
Published on: Apr 1, 2017
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services
© 2017 Vishesh Kumar, Shawn Kelly, Amol Raizada, Jimmy Yee, Amornpol Anuwatworn, Adam Stys, Maria Stys, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.