Testosterone and the Heart
References
- Matsumoto AM Bremner WJ. Testicular Disorders. In: Melmed S , Polonsky KS , Larsen PR , Kronenberg HM , editors. Williams Textbook of endocrinology, 13th ed. New York: Elsevier Health Sciences; ©2015. p. 688– 777.
-
Kloner
RA
,
Carson
C
3rd , Dobs A , Kopecky S , Mohler ER3rd . Testosterone and Cardiovascular Disease. J Am Coll Cardiol. 2016 Feb 9; 67 5: 545– 57. - Oskui PM , French WJ , Herring MJ , Mayeda GS , Burstein S , Kloner RA. Testosterone and the cardiovascular system: a comprehensive review of the clinical literature. J Am Heart Assoc. 2013 Nov 15; 2 6: e000272.
- Herati AS , Cengiz C , Lamb DJ. Assays of Serum Testosterone. Urol Clin North Am. 2016 May; 43 2: 177– 84.
- Er F , Michels G , Brandt MC , Impact of testosterone on cardiac L-type calcium channels and Ca2+ sparks: acute actions antagonize chronic effects. Cell Calcium. 2007 May; 41 5: 467– 77.
- Morgentaler A , Miner MM , Caliber M , Guay AT , Khera M , Traish AM. Testosterone therapy and cardiovascular risk: advances and controversies. Mayo Clin Proc. 2015 Feb; 90 2: 224– 51.
- Zarotsky V , Huang MY , Carman W , Systematic literature review of the epidemiology of nongenetic forms of hypogonadism in adult males. J Hormones. 2014 Jul 22; 2014: 190347.
- Ruige JB , Mahmoud AM , De Bacquer D , Kaufman JM. Endogenous testosterone and cardiovascular disease in healthy men: a meta-analysis. Heart. 2011 Jun; 97 11: 870– 5.
- Araujo AB , Dixon JM , Suarez EA , Murad MH , Guey LT , Wittert GA. Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011 Oct; 96 10: 3007– 19.
- Corona G , Rastrelli G , Monami M , Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study. Eur J Endocrinol. 2011 Nov; 165 5: 687– 701.
- Oskui PM , French WJ , Herring MJ , Mayeda GS , Burstein S , Kloner RA. Testosterone and the cardiovascular system: a comprehensive review of the clinical literature. J Am Heart Assoc. 2013 Nov 15; 2 6: e000272.
- Jankowska EA , Biel B , Majda J , Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival. Circulation. 2006 Oct 24; 114 17: 1829– 37.
- Wehr E , Pilz S , Boehm BO , März W , Grammer T , Obermayer-Pietsch B. Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography. Eur J Heart Fail. 2011 May; 13 5: 482– 8.
- Brand JS , Rovers MM , Yeap BB , Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies. PLoS One. 2014 Jul 14; 9 7: e100409.
- Mulligan T , Frick MF , Zuraw QC , Stemhagen A , McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006 Jul; 60 7: 762– 9.
- Corona G , Monami M , Rastrelli G , Testosterone and metabolic syndrome: a meta-analysis study. J Sex Med. 2011 Jan; 8 1: 272– 83.
- Vigen R , O'Donnell CI , Barón AE , Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013 Nov 6; 310 17: 1829– 36.
- Finkle WD , Greenland S , Ridgeway GK , , Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men. PLoS One. 2014 Jan 29; 9 1: e85805.
- Morgentaler A , Zitzmann M , Traish AM , Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Consensus Resolutions. Mayo Clin Proc. 2016 Jul; 91 7: 881– 96.
- Sharma R , Oni OA , Gupta K , Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J. 2015 Oct 21; 36 40: 2706– 15.
- Anderson JL , May HT , Lappé DL , Impact of Testosterone Replacement Therapy on Myocardial Infarction, Stroke, and Death in Men With Low Testosterone Concentrations in an Integrated Health Care System. Am J Cardiol. 2016 Mar 1; 117 5: 794– 9.
- Baillargeon J , Urban RJ , Kuo YF , Risk of Myocardial Infarction in Older Men Receiving Testosterone Therapy. Ann Pharmacother. 2014 Sep; 48 9: 1138– 44.
- Corona G , Maseroli E , Rastrelli G , Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis. Expert Opin Drug Saf. 2014 Oct; 13 10: 1327– 51.
- English KM , Steeds RP , Jones TH , Diver MJ , Channer KS. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study. Circulation. 2000 Oct 17; 102 16: 1906– 11.
- Rosano GM , Leonardo F , Pagnotta P , Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation. 1999 Apr 6; 99 13: 1666– 70.
- Webb CM , Adamson DL , de Zeigler D , Collins P. Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am J Cardiol. 1999 Feb 1; 83 3: 437– 9, A9.
- Dos Santos MR , Sayegh AL , Bacurau AV , Effect of Exercise Training and Testosterone Replacement on Skeletal Muscle Wasting in Patients With Heart Failure With Testosterone Deficiency. Mayo Clin Proc. 2016 May; 91 5: 575– 86.
- Toma M , McAlister FA , Coglianese EE , Testosterone supplementation in heart failure: a meta-analysis. Circ Heart Fail. 2012 May 1; 5 3: 315– 21.
- Sonmez A , Taslipinar A , Tapan S , Serdar MA. Comment on: Jones et al. Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 Study). Diabetes Care 2011; 34: 828– 837. Diabetes Care. 2011 Nov;34(11):e172; author's reply e173.
- Heufelder AE , Saad F , Bunck MC , Gooren L. Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. J Androl. 2009 Nov–Dec; 30 6: 726– 33.
- Kapoor D , Goodwin E , Channer KS , Jones TH. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol. 2006 Jun; 154 6: 899– 906.
- Kalinchenko SY , Tishova YA , Mskhalaya GJ , Gooren LJ , Giltay EJ , Saad F. Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study. Clin Endocrinol (Oxf). 2010 Nov; 73 5: 602– 12.
- Dhindsa S , Ghanim H , Batra M , Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes. Diabetes Care. 2016 Jan; 39 1: 82– 91.
- Calof OM , Singh AB , Lee ML , Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci. 2005 Nov; 60 11: 1451– 7.
- Boyle P , Koechlin A , Bota M , Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate-specific antigen (PSA) level: a meta-analysis. BJU Int. 2016 Nov; 118 5: 731– 41.
- Fernández-Balsells MM , Murad MH , Lane M , Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2010 Jun; 95 6: 2560– 75.
- Smith AM , English KM , Malkin CJ , Jones RD , Jones TH , Channer KS. Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina. Eur J Endocrinol. 2005 Feb; 152 2: 285– 91.
- Holmegard HN , Nordestgaard BG , Schnohr P , Tybjaerg-Hansen A , Benn M. Endogenous sex hormones and risk of venous thromboembolism in women and men. J Thromb Haemost. 2014; 12 3: 297– 305.
- Ramasamy R , Scovell J , Mederos M , Ren R , Jain L , Lipshultz L. Association Between Testosterone Supplementation Therapy and Thrombotic Events in Elderly Men. Urology. 2015 Aug; 86 2: 283– 5.
- Onasanya O , Iyer G , Lucas E , Lin D , Singh S , Alexander GC. Association between exogenous testosterone and cardiovascular events: an overview of systematic reviews. Lancet Diabetes Endocrinol. 2016 Nov; 4 11: 943– 56.
DOI: https://doi.org/10.14797/mdcj-13-2-68 | Journal eISSN: 1947-6108
Language: English
Page range: 68 - 72
Published on: Apr 1, 2017
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services
Keywords:
© 2017 Travis Goodale, Archana Sadhu, Steven Petak, Richard Robbins, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.