Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases

Dipti Deshpande; David R. Janero; Victor Segura-Ibarra; Elvin Blanco; Mansoor M. Amiji

doi:10.14797/mdcj-12-3-134

Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases

Methodist DeBakey Cardiovascular Journal

Volume 12 (2016): Issue 3

By: Dipti Deshpande, David R. Janero, Victor Segura-Ibarra, Elvin Blanco and Mansoor M. Amiji

Open Access

|Jul 2016

Abstract

Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.

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Articles in this issue

DOI: https://doi.org/10.14797/mdcj-12-3-134 | Journal eISSN: 1947-6108

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Language: English

Page range: 134 - 140

Published on: Jul 1, 2016

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

endothelium,

nucleic acids,

nanoparticle delivery,

cardiovascular diseases,

CVD,

inflammation,

oxidative stress,

DNA damage,

miRNA,

oligonucleotide-based therapeutics

© 2016 Dipti Deshpande, David R. Janero, Victor Segura-Ibarra, Elvin Blanco, Mansoor M. Amiji, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 12 (2016): Issue 3