Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy
Abstract
Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.
DOI: https://doi.org/10.14797/mdcj-11-3-166 | Journal eISSN: 1947-6108
Language: English
Page range: 166 - 171
Published on: Jul 1, 2015
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services
Keywords:
© 2015 Roman A. Sukhovershin, Gautham Yepuri, Yohannes T. Ghebremariam, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.