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NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significance Cover

NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significance

By:  and    
Open Access
|Apr 2013

Figures & Tables

Figure 1

Time frame of short-term and long-term adaptation to hypertonic stress.

Figure 2

Members of NFAT family and schematic diagram of NFAT5 functional domains. A) Alignment of NFAT1-4 with NFAT5. The DNA-binding domains (Rel homology domain) are aligned. The calcineurin-binding domain present in NFAT1-4 is absent in NFAT5. B) Overall structure of human NFAT5 protein. Sequence and phosphorylation sites in proximity to the AED are indicated. The corresponding amino acid residues are in parenthesis.

Table 1

Molecular targets of NFAT5

Types Name Function Evidences (R/E/C/I)* Refs.
Others S100A4/metastasin-1Cell motility and tumor metastasis.R, C, I[60-62]

*R – Reporter gene assay, E – EMSA, C – ChIP, I – Inhibition of NFAT5 (gene knockdown/gene knockout).

Language: English
Published on: Apr 23, 2013
Published by: Danny N. Dhanasekaran
In partnership with: Paradigm Publishing Services

© 2013 Chris Y K Cheung, Ben C B Ko, published by Danny N. Dhanasekaran
This work is licensed under the Creative Commons Attribution 4.0 License.