Figure 1
IL-24 suppresses tumorosphere formation by lung cancer stem cells. Aldehyde dehydrogenase positive (ALDH+) human lung cancer stem cells (CSCs) when treated with Ad-IL24 showed reduced tumorosphere formation in vitro.
Figure 2
Molecular signaling pathways regulated by MDA-7/IL-24 in human cancer cells. Schematic summarizes the findings made in clinical and preclinical studies demonstrating molecular signaling pathways that are regulated by IL-24 thereby inhibiting cancer cell growth, invasion and metastasis.