Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice

Reade B Roberts; Carol L Thompson; Daekee Lee; Richard W Mankinen; Aziz Sancar; David W Threadgill

doi:10.1186/1740-3391-4-15

Figures & Tables

Table 1

Activity measurements at 200–300 lux

Mouse number	Strain	Genotype	Total activity^a	Daytime activity^b	Masking^c
1	C57BL/6J	+	30154	1.82	99.33
2	C57BL/6J	+	37951	0.28	99.45
3	C57BL/6J	+	44485	0.86	97.35
4	C57BL/6J	Wnt3a^vt/vt	23509	1.43	99.72
5	B6.129 F1	+	51014	1.44	95.82
6	B6.129 F1	+	39133	0.74	96.10
7	C57BL/6J	Egfr^wa2/wa2	27630	30.22	66.25
8	C57BL/6J	Egfr^wa2/wa2	21821	1.30	95.82
9	C57BL/6J	Egfr^wa2/wa2	40884	0.08	99.97
10	C57BL/6J	Egfr^wa2/wa2	33975	1.16	97.80
11	C57BL/6J	Egfr^wa2/wa2	31997	0.55	97.97
12	C57BL/6J	Egfr^wa2/wa2	38165	1.95	80.49
13	C57BL/6J	Egfr^wa2/wa2	35818	0.98	99.37
14	C57BL/6J	Egfr^wa2/wa2	37774	0.39	99.27
15	C57BL/6J	Egfr^wa2/wa2	21888	1.92	97.39
16	B6.129 F1	Egfr^wa2/wa2	43930	17.55	26.63
17	B6.129 F1	Egfr^wa2/wa2	46505	1.41	97.50

^aAverage number of wheel revolutions per twenty-four hour period.

^bPercentage of total wheel revolutions during light cycle.

^cPercent suppression of activity during three-hour light pulse given during the dark cycle, relative to activity in the same dark cycle time period on the previous day.

**Locomotor activity in *Egfr*^wa2/wa2mice during 12 h:12 h light:dark cycles and three-hour light pulses given during the dark cycle**. Horizontal white and black bars represent light and dark exposure, respectively. Vertical axis indicates wheel-running activity. (A) The majority of *Egfr*^wa2/wa2mice tested were indistinguishable from wildtype controls in behavior, though two *Egfr*^wa2/wa2mice did exhibit a phase shift resulting in abnormally high daytime activity, as well as abnormally high activity during a three hour light pulse. (B) Abnormal wheel running activity during three-hour light pulses followed a characteristic one-hour of activity suppression in three *Egfr*^wa2/wa2mice (red), while wildtype (dark blue) and the majority of *Egfr*^wa2/wa2mice (light blue) demonstrated suppression of activity throughout the pulse. Grey areas, lights off; white area, light pulse.

Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice

Figures & Tables

Table 1

Figure 1

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