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Correlation of rheoencephalography and laser Doppler flow: a rat study Cover

Correlation of rheoencephalography and laser Doppler flow: a rat study

Journal of Electrical Bioimpedance
Volume 7 (2016): Issue 1 (January 2016)
By: Michael Bodo,  Ryan Sheppard,  Aaron Hall,  Martin Baruch,  Melissa Laird,  Shravalya Tirumala and  Richard Mahon  
Open Access
|Dec 2016

Figures & Tables

Fig. 1

Anatomical positions of REG, EEG electrodes and LDF probe are shown implanted in a rat skull (dorsal view). Standard orientation points in rat neurophysiology: bregma and lambda points and sutura between bones.
Anatomical positions of REG, EEG electrodes and LDF probe are shown implanted in a rat skull (dorsal view). Standard orientation points in rat neurophysiology: bregma and lambda points and sutura between bones.

Fig. 2

Block schematics showing REG and LDF measured during rat CO2 inhalation challenges and data processing of resulting signals stored in a computer (PC). Data were first processed using DataLyser software to process analog signals; numbers generated were then put into an Excel software spread sheet for calculation of percentages of control values, group mean and SD. Next, percent values of REG and LDF were put into a Prism software spreadsheet for calculation of ROC and AUC.
Block schematics showing REG and LDF measured during rat CO2 inhalation challenges and data processing of resulting signals stored in a computer (PC). Data were first processed using DataLyser software to process analog signals; numbers generated were then put into an Excel software spread sheet for calculation of percentages of control values, group mean and SD. Next, percent values of REG and LDF were put into a Prism software spreadsheet for calculation of ROC and AUC.

Fig. 3

Impact of CO2 inhalation on LDF flux and REG signals, in real time: CO2 increases were followed by simultaneous increases in LDF flux and REG signal amplitudes. For all traces, Y axis is shown in volts; X axis is shown in seconds. Traces, from top, are REG raw signal; REG proc (processed signal, displayed as a running integral); EKG; Respiration (measured by bioimpedance); LDF flux; inhaled CO2.
Impact of CO2 inhalation on LDF flux and REG signals, in real time: CO2 increases were followed by simultaneous increases in LDF flux and REG signal amplitudes. For all traces, Y axis is shown in volts; X axis is shown in seconds. Traces, from top, are REG raw signal; REG proc (processed signal, displayed as a running integral); EKG; Respiration (measured by bioimpedance); LDF flux; inhaled CO2.

Fig. 4

ROC curve of LDF and REG. Area under curve (AUC): 0.8394 with p<0.0001; Std. error: 0.03693; 95 % confidence interval: 0.7670 to 0.9118. Figure and numbers are presented as Prism program shown and calculated from the percent values of REG and LDF signals.
ROC curve of LDF and REG. Area under curve (AUC): 0.8394 with p<0.0001; Std. error: 0.03693; 95 % confidence interval: 0.7670 to 0.9118. Figure and numbers are presented as Prism program shown and calculated from the percent values of REG and LDF signals.
DOI: https://doi.org/10.5617/jeb.2985 | Journal eISSN: 1891-5469
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Language: English
Page range: 55 - 58
Submitted on: Jun 20, 2016
Published on: Dec 5, 2016
Published by: University of Oslo
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
neuro-monitoring,
laser Doppler flow,
rheoencephalogram,
CO2 inhalation,
animal study (rat)
Related subjects:
Engineering,
Bioengineering and biomedical engineering,
Biomedical electronics,
Life sciences,
Biophysics,
Medicine,
Biomedical engineering,
Physics,
Spectroscopy and metrology

© 2016 Michael Bodo, Ryan Sheppard, Aaron Hall, Martin Baruch, Melissa Laird, Shravalya Tirumala, Richard Mahon, published by University of Oslo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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