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Overview of Trends in Global Single Cell Research Based on Bibliometric Analysis and LDA Model (2009–2019) Cover

Overview of Trends in Global Single Cell Research Based on Bibliometric Analysis and LDA Model (2009–2019)

Open Access
|Nov 2020

Figures & Tables

Figure 1

Annual publications on single cell research from 2009 to 2019 (Based on the WoS data).
Annual publications on single cell research from 2009 to 2019 (Based on the WoS data).

Figure 2

Production and collaboration analysis of countries. a. Top10 most productive countries. b. Collaboration network of the top10 most productive countries.
Production and collaboration analysis of countries. a. Top10 most productive countries. b. Collaboration network of the top10 most productive countries.

Figure 3

Perplexity-avg_sim curve of LDA model. avg_sim: average similarity.
Perplexity-avg_sim curve of LDA model. avg_sim: average similarity.

Figure 4

Topic strength of 19 topics on single cell research. X-coordinate: Years; Y-coordinate: Topic Strength.
Topic strength of 19 topics on single cell research. X-coordinate: Years; Y-coordinate: Topic Strength.

Figure 5

Topic distributions of the top10 most productive countries.
Topic distributions of the top10 most productive countries.

Figure 6

The topic distribution trend of China.
The topic distribution trend of China.

Figure 7

Topic evolution trends of the top10 productive countries of topic13.
Topic evolution trends of the top10 productive countries of topic13.

Topics identified by LDA model (K=20)_

TopicPotential topicTop20 frequent terms
0Pathology of brain diseasedisease; brain; distribution; relationship; region; pattern; nucleus; age; immunohistochemistry; human brain; cortex; proportion; purpose; hippocampus; cluster; focus; rat; input; neuron; pathology
1Mathematical modeling of cell cyclemodel; type; control; mechanism; betum; datum; network; cell cycle; complexity; framework; phase; association; simulation; modeling; mouse model; differential expression; account; interplay; prediction; balance
2Single cell detection platformdetection; imaging; platform; fluorescence; sensitivity; design; resolution; quantification; device; mass spectrometry; living; sample; measurement; spectrometry; flow; array; magnitude; capability; microfluidic device; chip
3Immune responsesingle-cell level; flow cytometry; infection; biology; single-cell analysis; cytometry; host; memory; emergence; virus; pathogenesis; set; health; inflammation; immune response; immune system; complex; initiation; immunity; site
4Signal transductionresponse; activity; vivo; activation; pathway; receptor; factor; target; inhibition; phenotype; replication; inhibitor; signaling; overexpression; depletion; miRNA; kinase; zebrafish; oxygen; angiogenesis
5Phylogeny on single cell levelsequencing; identification; protocol; diversity; genome; situ hybridization; selection; mutation; life; amplification; analysis; sequence; accuracy; family; transfer; chromosome; classification; genus; total; syndrome
6Intracellular calcium modulationcombination; generation; increase; frequency; alpha; action; calcium; injury; channel; layer; heart; stability; difference; modulation; transmission; strength; central nervous system; ion; mu m; mechanism
7Single cell gel electrophoresistreatment; damage; assay; exposure; repair; stress; comparison; apoptosis; cell line; extent; risk; carcinoma; peripheral blood; kidney; glioblastoma; liver; assessment; evaluation; radiation; toxicity
8Molecular mechanism of embryonic developmentdevelopment; mouse; tissue; single-cell resolution; embryo; transcriptome; origin; stage; cell type; mapping; morphogenesis; establishment; skin; immunofluorescence; nervous system; gap; epithelium; molecular mechanism; specification; resource
9Cell adhesionmicroscopy; surface; interaction; adhesion; spectroscopy; different cell; manipulation; motility; extracellular matrix; binding; chemical; cell surface; force; substrate; bacterium; atomic force; speed; aeruginosa; spectra; spectrum
10Isolation and sorting of single cellsingle cell; range; isolation; quality; cycle; engineering; antibody; viability; delivery; screening; enrichment; field; high throughput; throughput; amount; droplet; suspension; cell viability; red blood; solution
11Cell migrationprotein; migration; rate; contrast; loss; context; absence; transition; invasion; cell division; localization; density; organism; division; cell migration; cell size; decrease; fraction; literature; core
12Cell-to-cell variability analysisexpression; gene expression; gene; population; transcription; regulation; mRNA; evolution; variability; variation; chromatin; transcription factor; protein expression; correlation; noise; phenotypic; promoter; reporter; cell-to-cell variability; gene regulation
13Cancer diagnosis and treatmentcancer; tumor; blood; resistance; therapy; progression; survival; breast cancer; drug; patient; metastasis; death; lung; efficacy; diagnosis; treatment; melanoma; microenvironment; cell death; persistence
14Single cell oilgrowth; production; yeast; concentration; metabolism; ratio; composition; content; reduction; source; accumulation; plant; degradation; synthesis; abundance; medium; energy; strain; recovery; oil
15Stem celldifferentiation; vitro; stem; culture; proliferation; methylation; adult; lineage; regeneration; capacity; progenitor; stem cell; rise; pluripotent stem; fate; bone marrow; maintenance; expansion; marker; embryonic stem
16Cellular heterogeneity analysisanalysis; single cell; heterogeneity; level; single-cell; size; cellular heterogeneity; integration; cell population; bulk; volume; chapter; acquisition; individual cell; glioma; drug discovery; cell analysis; tummy; significance; conjunction
17Single cell living imagingaddition; potential; membrane; release; stimulation; homeostasis; secretion; situ; change; uptake; transport; cytoplasm; fluorescence microscopy; gamma; iuss; fusion; plasma membrane; phosphorylation; cell biology; real time
18Biofilm formationformation; structure; environment; behavior; light; body; community; form; plasticity; processing; degree; matrix; shape; nature; length; organization; adaptation; space; fixation; assembly
DOI: https://doi.org/10.2478/jdis-2021-0008 | Journal eISSN: 2543-683X | Journal ISSN: 2096-157X
Language: English
Page range: 163 - 178
Submitted on: Sep 8, 2020
Accepted on: Oct 23, 2020
Published on: Nov 27, 2020
Published by: Chinese Academy of Sciences, National Science Library
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 Tian Jiang, Xiaoping Liu, Chao Zhang, Chuanhao Yin, Huizhou Liu, published by Chinese Academy of Sciences, National Science Library
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.